Roles of Cyclic AMP Receptor Protein (CRP) in Transcriptional Regulation of Kinases and Phosphatases in Escherichia Coli PDF Download
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Author: Hui-Ying Huang
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Languages : en
Pages :
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Author: Hui-Ying Huang
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Languages : en
Pages :
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Author: Karin Lederballe Meibom
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Category :
Languages : en
Pages :
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![The Role of Cyclic AMP Receptor Protein and [alpha]-CTD in Transcription Regulation at the Divergent RhaSR-rhaBAD Promoters in Escherichia Coli PDF](https://books.google.com/books/content/images/frontcover/QUbhNwAACAAJ?fife=w80-h100)
Author: Carolyn Claire Holcroft
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Languages : en
Pages : 302
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Author: Virgil Arthur Rhodius
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Category :
Languages : en
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Languages : en
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Category : Medicine
Languages : en
Pages : 1400
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Author: K. Shimizu
Publisher: Elsevier
ISBN: 1908818204
Category : Science
Languages : en
Pages : 497
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The metabolic regulation of a cell system is of critical importance in systems biology, and a robust model of these mechanisms is essential in predicting the effects on the metabolism of both the culture environment and the knockout of specific genes. Bacterial cellular metabolic systems focuses on this highly topical subject in relation to culture environment and provides a detailed analysis from gene level to metabolic level regulation, as well as offering a discussion of the most recent modelling approaches. The book begins with an introduction to metabolic mechanisms and to the metabolic regulation of a cell, before moving on to discussing the action of global regulators in response to a specific culture environment. The second half of the book examines conventional flux balance analysis and its applications, 13C-metabolic flux analysis, and the effect of a specific gene knockout on the metabolism. - Comprehensive account of metabolic regulation via global regulators in response to changes in the culture environment - Basic formulation of 13C-metabolic flux analysis based on 13C-labelling experiments - Systems biology approach for the modelling and computer simulation of the main metabolic pathways of a cell system
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Category : Medicine
Languages : en
Pages : 1192
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Author: John Tebbutt
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Category :
Languages : en
Pages : 181
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Author: Walter J. Dobrogosz
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Category :
Languages : en
Pages : 19
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Various metabolic functions associated with the Escherichia coli membrane system were analyzed in mutant strains lacking adenylate cyclase (cya mutations) or cyclic AMP binding protein (CRP) activity (crp mutations). Mutations which have suppressed the organism's requirement for cyclic AMP were also studied, and mutants of Salmonella typhimurium were constructed which are cya or crp in addition to lacking the enzymes of the phosphoenolpyruvate: phosphotransferase system (PTS). These studies have established that key transport and bioenergetic activities of the enterobacterial membrane are regulated at the genetic level of transcription by the cAMP-CRP regulatory complex. The ability of E. coli to transport substrates via PTS and non-PTS routes are under this control. The organism's ability to generate a proton motive force (PMF) and to link this force to transport activities and ATP synthesis are also under this control. All parts of the E. coli envelope, the inner, cytoplasmic membrane, the periplasmic region, and the outer membrane are to one degree or another affected by the cAMP-CRP regulatory function.
