Retroviral Proteases PDF Download
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Author: Lawrence C. Kuo
Publisher: Gulf Professional Publishing
ISBN: 9780121821425
Category : Medical
Languages : en
Pages : 494
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Book Description
Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.
Author: Lawrence C. Kuo
Publisher: Gulf Professional Publishing
ISBN: 9780121821425
Category : Medical
Languages : en
Pages : 494
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Book Description
Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.
Author: Satya Prakash Gupta
Publisher: Academic Press
ISBN: 0128096829
Category : Science
Languages : en
Pages : 518
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Book Description
Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents. Provides comprehensive, state-of-the-art coverage of virus infections, the virus lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of each viral protease Presents an in-depth view of the structure and function of viral proteases
Author: Alan J. Barrett
Publisher: Elsevier
ISBN: 0080984150
Category : Science
Languages : en
Pages : 1182
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Book Description
Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.
Author: Vladimír Kostka
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110862786
Category : Science
Languages : en
Pages : 220
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Book Description
No detailed description available for "Proteases of Retroviruses".
Author: Matthias Gotte
Publisher: Springer
ISBN: 9781493906932
Category : Medical
Languages : en
Pages : 0
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Book Description
While many volumes have been written about various aspects of antimicrobial resistance, this book is a comprehensive reference work. All manifestations of resistance are addressed: viral; bacterial, parasitical and fungal are given dedicated sections. The underlining molecular mechanisms, which depend not only on the microbe but on the specific drug (target), are highly diverse. This work discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.
Author: Arun K. Ghosh
Publisher: John Wiley & Sons
ISBN: 3527641629
Category : Medical
Languages : en
Pages : 616
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Book Description
In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases. A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.
Author: Uwe Lendeckel
Publisher: Springer Science & Business Media
ISBN: 9048123488
Category : Medical
Languages : en
Pages : 139
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Book Description
The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.
Author: Laurence H. Pearl
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 200
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Book Description
This volume describes the state-of-the-art of our understanding of the structure and function of retroviral proteases, and their substrates, the viral polyproteins, described by the leading workers in the field. The contributions range from detailed biochemical and structural characterisation of several retroviral proteases including that from HIV-1, through the analysis of the proteolytic processing of the viral polyproteins, to the structure of the viral capsids formed by the action of the protease, and is essential reading for anyone interested in the molecular biology of AIDS.
Author:
Publisher: Academic Press
ISBN: 0080865968
Category : Technology & Engineering
Languages : en
Pages : 471
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Book Description
The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.
Author: Stefan Offermanns
Publisher: Springer Science & Business Media
ISBN: 3540389164
Category : Medical
Languages : en
Pages : 1515
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Book Description
An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
