Regulation of the Alpha-6/beta-1 Integrin Function by the Cytoplasmic Domains of the Alpha-6 Subunit PDF Download
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Author: Leslie MacDougall Shaw
Publisher:
ISBN:
Category : Cytoplasm
Languages : en
Pages : 220
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Author: Leslie MacDougall Shaw
Publisher:
ISBN:
Category : Cytoplasm
Languages : en
Pages : 220
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Book Description
Author: Edward Eugene Morrisey
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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![The Integrins [alpha]3[beta]1 and [alpha]6[beta]1 PDF](https://books.google.com/books/content/images/frontcover/I2ULMwEACAAJ?fife=w80-h100)
Author: Annemieke Aagje de Melker
Publisher:
ISBN:
Category :
Languages : en
Pages : 167
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 30
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The expression of different cytoplasmic domains could influence the function of the alpha 6 beta l laminin receptor integrin by affecting the ligand binding characteristics of the integrin or by altering the intracellular interactions between alpha 6 and cytosolic components (i.e.
Author: Erik H.J. Danen
Publisher: CRC Press
ISBN:
Category : Science
Languages : en
Pages : 244
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Book Description
Cell adhesion is essential for the organization of multicellular organisms. Indeed, various types of cell adhesion receptors, including cadherins and integrins, are present in animals ranging from nematodes and insects to vertebrates. In this book, we focus on the integrin family, which is shared among all metazoans, but has expanded considerably with vertebrate evolution. Since the cloning of the first integrin subunit, some twenty years ago, integrin biology has been—and still is—a topic of intense study. Integrin-mediated adhesion is a regulated process that, in turn, regulates the organization of the actin cytoskeleton. Moreover, it has become clear from in vitro analyses that integrin-mediated adhesion can affect virtually all aspects of cellular behavior—including polarity, motility, proliferation, survival, and differentiation. This book aims to provide an extensive overview of the current knowledge about the regulation of developmental processes as well as the maintenance of proper tissue function, by integrin-mediated adhesion. In addition, key aspects of integrin cell biology are discussed. Chapter 1 of this book is meant as an introduction in integrin biology and is followed by a more in-depth discussion of the roles that integrins play in extracellular matrix assembly, in cell migration, and in the regulation of intracellular signaling cascades (Chapters 2-4). Subsequently, Chapters 5 and 6 discuss what has been learned about the role of integrins and associated proteins in animal development from genetic analysis of two invertebrates— the flatworm, C. elegans and the fruit fly, D. melanogaster. The relatively limited number of genes encoding adhesion-related proteins and the relative ease and speed with which genetic experiments can be performed in these animals, have allowed researchers to study the basic principles of integrin biology in vivo. Finally, Chapters 7-14 discuss how integrin-mediated adhesion regulates the development and functionality of the different mammalian organ systems, based to a large extent on (conditional) gene knockout studies in mice and on studies in human patients.
Author: Donald Gullberg
Publisher: Springer
ISBN: 9401791538
Category : Medical
Languages : en
Pages : 188
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Book Description
The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version. I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition. Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book. In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling. New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins.
Author: Yoshikazu Takada
Publisher: CRC Press
ISBN: 1351361252
Category : Medical
Languages : en
Pages : 550
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Book Description
* the structure and functions of integrin cytoplasmic domains * the role of b2 integrins in leukocyte adhesion * the role of platelet membrane fibrinogen receptor glycoprotein IIb-IIIa (aIIbb3) in thrombosis and hemostasis * the functions of aV integrin family * the role of integrins in signal transduction
Author: David A. Cheresh
Publisher: Academic Press
ISBN: 0121711609
Category : Medical
Languages : en
Pages : 297
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Book Description
Integrins: Molecular and Biological Responses to the Extracellular Matrix will help basic, applied, and clinical researchers keep up with the explosion of literature on the integrin family of proteins. This volume extends material previously covered in Receptors for Extracellular Matrix. It addresses some of the most exciting areas of integrin biology, including the varied roles of integrins in cell division, differentiation, movement, wound healing, inflammation, thrombosis, osteoporosis, and cancer. Describes key aspects of integrin structure, function, and biology Covers collagen receptors, epithelial cell integrins, leukocyte integrins, platelet integrins, integrin signaling, and integrin antagonists Investigates the expression and role of integrins during development and in the cytoskeleton Includes the actions and influences of integrins in inflammation, thrombosis, and osteoporosis
