Author: Benjamin Preiss
Publisher: Elsevier
ISBN: 0323155146
Category : Nature
Languages : en
Pages : 343
Book Description
Regulation of HMG-CoA Reductase is a nine-chapter text that focuses on the research developments in the regulation of HMG-CoA reductase enzyme and cholesterol biosynthesis. This book deals first with the role of cholesterol in the regulation of its own biosynthesis and the work involving compactin and related competitive inhibitors of HMG-CoA reductase. The subsequent chapters examine the reversible phosphorylation of HMG-CoA reductase in hormonal and other short-term physiological changes and the structure and properties of the enzyme, including evidence for modulation of enzyme activity and structure unrelated to phosphorylation. These topics are followed by discussions on the regulation of reductase in the biosynthesis of ubiquinone, dolichols, and isopentenyl-tRNA and the regulation of reductase activity in extrahepatic tissues. This text further explores the contributions made through the use of cultured cells and their genetic manipulation, with emphasis on the great potential of this approach. The concluding chapters address the status of the low-density lipoprotein pathway and related mechanisms. These chapters also consider the regulation of human hepatic HMG-CoA reductase and the special problems inherent in work with human tissues. Enzyme scientists and researchers and graduate students will find this book invaluable.
Regulation of HMG-CoA Reductase
Author: Benjamin Preiss
Publisher: Elsevier
ISBN: 0323155146
Category : Nature
Languages : en
Pages : 343
Book Description
Regulation of HMG-CoA Reductase is a nine-chapter text that focuses on the research developments in the regulation of HMG-CoA reductase enzyme and cholesterol biosynthesis. This book deals first with the role of cholesterol in the regulation of its own biosynthesis and the work involving compactin and related competitive inhibitors of HMG-CoA reductase. The subsequent chapters examine the reversible phosphorylation of HMG-CoA reductase in hormonal and other short-term physiological changes and the structure and properties of the enzyme, including evidence for modulation of enzyme activity and structure unrelated to phosphorylation. These topics are followed by discussions on the regulation of reductase in the biosynthesis of ubiquinone, dolichols, and isopentenyl-tRNA and the regulation of reductase activity in extrahepatic tissues. This text further explores the contributions made through the use of cultured cells and their genetic manipulation, with emphasis on the great potential of this approach. The concluding chapters address the status of the low-density lipoprotein pathway and related mechanisms. These chapters also consider the regulation of human hepatic HMG-CoA reductase and the special problems inherent in work with human tissues. Enzyme scientists and researchers and graduate students will find this book invaluable.
Publisher: Elsevier
ISBN: 0323155146
Category : Nature
Languages : en
Pages : 343
Book Description
Regulation of HMG-CoA Reductase is a nine-chapter text that focuses on the research developments in the regulation of HMG-CoA reductase enzyme and cholesterol biosynthesis. This book deals first with the role of cholesterol in the regulation of its own biosynthesis and the work involving compactin and related competitive inhibitors of HMG-CoA reductase. The subsequent chapters examine the reversible phosphorylation of HMG-CoA reductase in hormonal and other short-term physiological changes and the structure and properties of the enzyme, including evidence for modulation of enzyme activity and structure unrelated to phosphorylation. These topics are followed by discussions on the regulation of reductase in the biosynthesis of ubiquinone, dolichols, and isopentenyl-tRNA and the regulation of reductase activity in extrahepatic tissues. This text further explores the contributions made through the use of cultured cells and their genetic manipulation, with emphasis on the great potential of this approach. The concluding chapters address the status of the low-density lipoprotein pathway and related mechanisms. These chapters also consider the regulation of human hepatic HMG-CoA reductase and the special problems inherent in work with human tissues. Enzyme scientists and researchers and graduate students will find this book invaluable.
Regulation of HMG-CoA Reductase Degradation
Author: Helen Hsin-I. Cheng
Publisher:
ISBN:
Category :
Languages : en
Pages : 398
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 398
Book Description
Regulation of HMG-COA Reductase in HTC Cells
Author: Owen Ross Beirne
Publisher:
ISBN:
Category : Acetic acid
Languages : en
Pages : 276
Book Description
Publisher:
ISBN:
Category : Acetic acid
Languages : en
Pages : 276
Book Description
Synthesis and Regulation of HMG-CoA Reductase
Author: Deborah Ann Brown
Publisher:
ISBN:
Category :
Languages : en
Pages : 426
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 426
Book Description
The regulation of HMG-CoA reductase by reversible phosphorylation
Author: Paul Robert Clarke
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Regulation of HMG-CoA Reductase in Compactin Resistant Cell Lines
Author: Edna Christine Hardeman
Publisher:
ISBN:
Category : Enzyme inhibitors
Languages : en
Pages : 384
Book Description
Publisher:
ISBN:
Category : Enzyme inhibitors
Languages : en
Pages : 384
Book Description
Regulation of HMG-COA Reductase Degradation and DNA Replication by Isoprenoid Pathway Products
Author: Thomas Edward Meigs
Publisher:
ISBN:
Category :
Languages : en
Pages : 478
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 478
Book Description
Cell Cycle Regulation of HMG-CoA Reductase
Author: Paul Glenn Held
Publisher:
ISBN:
Category :
Languages : en
Pages : 212
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 212
Book Description
HMG-CoA Reductase Inhibitors
Author: Gerd Schmitz
Publisher: Birkhäuser
ISBN: 3034881355
Category : Medical
Languages : en
Pages : 158
Book Description
HMG-CoA reductase inhibitors (statins) are established drugs for the treatment of hypercholesterolemia. Furthermore, they induce regression of vascular atherosclerosis as well as reduction of cardiovascular-related morbidity and death in patients with and without coronary artery disease. This book deals with statins which have substantially altered the approach to therapy of atherosclerosis and its sequelae. Emphasis is placed on the scientific background to the discoveries and the development of the therapy, including an overview of the current state of knowledge of the drugs. Clinical data are reviewed extensively. This book not only provides the reader with valuable information but also stimulates further research into the pathogenesis of atherosclerosis and the mechanisms behind the action of effective statins. It sets the stage for creative thinking among scientists of many disciplines for the accomplishment of our ultimate goals in treating atherosclerosis and its sequelae. This topical volume...
Publisher: Birkhäuser
ISBN: 3034881355
Category : Medical
Languages : en
Pages : 158
Book Description
HMG-CoA reductase inhibitors (statins) are established drugs for the treatment of hypercholesterolemia. Furthermore, they induce regression of vascular atherosclerosis as well as reduction of cardiovascular-related morbidity and death in patients with and without coronary artery disease. This book deals with statins which have substantially altered the approach to therapy of atherosclerosis and its sequelae. Emphasis is placed on the scientific background to the discoveries and the development of the therapy, including an overview of the current state of knowledge of the drugs. Clinical data are reviewed extensively. This book not only provides the reader with valuable information but also stimulates further research into the pathogenesis of atherosclerosis and the mechanisms behind the action of effective statins. It sets the stage for creative thinking among scientists of many disciplines for the accomplishment of our ultimate goals in treating atherosclerosis and its sequelae. This topical volume...
HMG-CoA Reductase
Author: Alexander Glennon Shearer
Publisher:
ISBN:
Category :
Languages : en
Pages : 390
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 390
Book Description