Racial Differences in Prostate Cancer Molecular Biology: An Evaluation of Tumor Suppressor Genes in BCL2, P53 and RB in Black and Africans PDF Download
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 12
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Book Description
Prostate Cancer is the most common cancer among African American males. Recent reports suggest that not only is the incidence higher than their white counterparts, but that they present at an earlier age with more diffuse disease, and have a higher morbidity and mortality. Our current study is designed to evaluate potential differences in tumor suppressor genes between cancers of non-Hispanic Whites and African Americans. We have selected the tumor suppressor genes BCL-2, p53 and Rb. We have selected cancers from America as well as South Africa to assess the potential for an increased virulence in African Americans compared to whites and Native Africans. In this initial grant we are funded to establish a laboratory and to prepare to write a Department of Defense grant that was submitted in the spring of 1999.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 12
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Book Description
Prostate Cancer is the most common cancer among African American males. Recent reports suggest that not only is the incidence higher than their white counterparts, but that they present at an earlier age with more diffuse disease, and have a higher morbidity and mortality. Our current study is designed to evaluate potential differences in tumor suppressor genes between cancers of non-Hispanic Whites and African Americans. We have selected the tumor suppressor genes BCL-2, p53 and Rb. We have selected cancers from America as well as South Africa to assess the potential for an increased virulence in African Americans compared to whites and Native Africans. In this initial grant we are funded to establish a laboratory and to prepare to write a Department of Defense grant that was submitted in the spring of 1999.
Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
ISBN:
Category : Government publications
Languages : en
Pages : 728
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Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1808
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Book Description
Author: George Klein
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 874
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Book Description
Author:
Publisher: Academic Press
ISBN: 0128123745
Category : Medical
Languages : en
Pages : 400
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Book Description
Role of Nutraceuticals in Chemoresistance to Cancer, Volume Two, focuses on nutraceuticals, the compounds derived from natural sources, which are usually multi-targeted as a means to overcome chemoresistance. This book discusses the role of several compounds related to nutraceuticals and chemoresistance, such as curcumin, resveratrol, indole 3-carbinol, tocotrienols, ursolic acid, fisetin, celastrol, gambogic, butein, catechins and silymarin. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use nutraceuticals as a sensitizing agent for chemotherapy. Brings updated information on natural compounds used as specific inhibitors of cell signaling pathways as reviewed by experts in the field Presents experts analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches for the readers to use in their own investigations
Author: Paul A. Schulte
Publisher: Academic Press
ISBN: 0323138578
Category : Medical
Languages : en
Pages : 609
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Book Description
This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.
Author: William B. Coleman
Publisher: Humana Press
ISBN: 1597454583
Category : Medical
Languages : en
Pages : 868
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Book Description
This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care. The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.
Author: Jack Cuzick
Publisher: Springer Science & Business Media
ISBN: 3642451950
Category : Medical
Languages : en
Pages : 167
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Book Description
Prostate cancer is by far the most common cancer in men and the second leading cause of death due to cancer. It comprises a mixed group of tumours displaying varying clinical behaviour: while some have a very aggressive course, others are rather indolent. Prevention of prostate cancer and discrimination between aggressive and indolent forms are important clinical goals and the acquisition of significant new evidence on means of achieving these aims makes this book particularly timely. A wide range of topics are covered by leading authorities in the field. The biology and natural history of prostate cancer are reviewed and the role of lifestyle and dietary factors, assessed. Detailed attention is paid to risk prediction biomarkers and to the role of novel high-throughput nucleic acid-based technologies in improving risk prediction and thereby allowing tailored approaches to cancer prevention. Potential means of chemoprevention of prostate cancer are also reviewed in depth, covering the very positive new data on the impact of aspirin as well as evidence regarding 5α-reductase inhibitors, DFMO and lycopene. Guidance is provided on the differentiation of aggressive from indolent disease and the policy and research implications of recent findings are examined. This book will be of interest to both clinicians and researchers.
Author: Scott M. Dehm
Publisher: Springer Nature
ISBN: 303032656X
Category : Medical
Languages : en
Pages : 483
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Book Description
The purpose of this book is to provide a contemporary overview of the causes and consequences of prostate cancer from a cellular and genetic perspective. Written by experts in the fields of epidemiology, toxicology, cell biology, genetics, genomics, cell-cell interactions, cell signaling, hormone signaling, and transcriptional regulation, the text covers aspects of prostate cancer from disease initiation to metastasis. Chapters explore in depth the cells of origin for prostate cancer, its genomic subtypes, neural transcription factors in disease progression, epigenetic regulation of chromatin, and many other topics. This book distinguishes itself from other texts on prostate cancer by its focus on cellular and genetic mechanisms, as opposed to clinical diagnosis and management. As a result, this book will be of broad interest to basic and translational scientists with familiarity of these topics, as well as to trainees at earlier stages of their research careers.
Author: K.G. Manton
Publisher: Springer Science & Business Media
ISBN: 0387781935
Category : Medical
Languages : en
Pages : 463
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Book Description
The purpose of this book is to examine the etiology of cancer in large human populations using mathematical models developed from an inter-disciplinary perspective of the population epidemiological, biodemographic, genetic and physiological basis of the mechanisms of cancer initiation and progression. In addition an investigation of how the basic mechanism of tumor initiation relates to general processes of senescence and to other major chronic diseases (e.g., heart disease and stroke) will be conducted.
