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Author: Aruna M
Publisher: Self Publisher
ISBN: 9781805250920
Category : Health & Fitness
Languages : en
Pages : 0
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Book Description
This is a comprehensive book that explores the potential of pyrazolo[4,3-c]pyridine and pyrido[4,3-d]pyrimidine scaffolds as anticancer agents. The book presents an experimental and theoretical evaluation of the biological activity of these compounds, highlighting their potential as therapeutic agents for the treatment of cancer. The author provides an in-depth analysis of the synthesis and characterization of these scaffolds, as well as their mechanism of action and structure-activity relationships. The book also explores the theoretical evaluation of the electronic and structural properties of these compounds, using computational chemistry methods. The book is a valuable resource for researchers, academics, and students in the fields of medicinal chemistry and drug discovery. It provides a detailed insight into the design and evaluation of new anticancer agents, with a particular focus on pyrazolo[4,3-c]pyridine and pyrido[4,3-d]pyrimidine scaffolds. With its clear and concise presentation of complex concepts, "Pyrazolo Pyridine Pyrimidine Scaffolds for Anticancer Activity" is an essential addition to any medicinal chemist's bookshelf. Overall, the book offers an interdisciplinary perspective on the potential of pyrazolo[4,3-c]pyridine and pyrido[4,3-d]pyrimidine scaffolds as promising anticancer agents, providing insights for researchers and scientists working towards the discovery of new therapies for cancer treatment.
Author: Aruna M
Publisher: Self Publisher
ISBN: 9781805250920
Category : Health & Fitness
Languages : en
Pages : 0
Get Book Here
Book Description
This is a comprehensive book that explores the potential of pyrazolo[4,3-c]pyridine and pyrido[4,3-d]pyrimidine scaffolds as anticancer agents. The book presents an experimental and theoretical evaluation of the biological activity of these compounds, highlighting their potential as therapeutic agents for the treatment of cancer. The author provides an in-depth analysis of the synthesis and characterization of these scaffolds, as well as their mechanism of action and structure-activity relationships. The book also explores the theoretical evaluation of the electronic and structural properties of these compounds, using computational chemistry methods. The book is a valuable resource for researchers, academics, and students in the fields of medicinal chemistry and drug discovery. It provides a detailed insight into the design and evaluation of new anticancer agents, with a particular focus on pyrazolo[4,3-c]pyridine and pyrido[4,3-d]pyrimidine scaffolds. With its clear and concise presentation of complex concepts, "Pyrazolo Pyridine Pyrimidine Scaffolds for Anticancer Activity" is an essential addition to any medicinal chemist's bookshelf. Overall, the book offers an interdisciplinary perspective on the potential of pyrazolo[4,3-c]pyridine and pyrido[4,3-d]pyrimidine scaffolds as promising anticancer agents, providing insights for researchers and scientists working towards the discovery of new therapies for cancer treatment.
Author: M. Aruna
Publisher:
ISBN: 9781805290575
Category : Medical
Languages : en
Pages : 0
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Book Description
Author explores the potential of pyrazolo 4 3 c pyridine pyrido 4 3 d pyrimidine scaffolds as a novel class of anticancer agents in her book. The book provides an experimental and theoretical evaluation of the scaffolds, exploring their chemical structures and properties, as well as their potential as anticancer agents. Author examines the molecular mechanisms underlying the anticancer activity of the scaffolds, as well as their pharmacokinetics and toxicological properties. The author also delves into the development of pyrazolo-pyridine-based drugs, from synthesis to preclinical studies, and the challenges and opportunities in translating these scaffolds into clinically useful anticancer agents. Overall, "Pyrazolo-Pyridine Scaffolds for Anticancer Activity" is a valuable resource for medicinal chemists, biochemists, and pharmacologists who are interested in the development of novel anticancer agents. The book offers practical guidance and insights into the design and development of pyrazolo-pyridine scaffolds for anticancer activity, as well as the challenges and opportunities in translating these scaffolds into effective cancer treatments.
Author:
Publisher: Academic Press
ISBN: 0123815347
Category : Medical
Languages : en
Pages : 481
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Book Description
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on insulin and IGFs. - Longest running series published by Academic Press - Contributions by leading international authorities
Author: Larry Yet
Publisher: John Wiley & Sons
ISBN: 1118686357
Category : Medical
Languages : en
Pages : 562
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Book Description
A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book describes the up-to-date and state-of-the-art methods of organic synthesis that describe the use of privileged structures that are of most interest. Chapters included information on benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry. Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume: Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry Details many of the recent developments in organic chemistry that prepare target molecules Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, Privileged Structures in Drug Discovery offers a current guide to organic synthesis methods to access the privileged structures of interest, and contains medicinal chemistry case studies that document their application.
Author: Xianhai Huang
Publisher: John Wiley & Sons
ISBN: 0470601817
Category : Medical
Languages : en
Pages : 488
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Book Description
Learn why some drug discovery and development efforts succeed . . . and others fail Written by international experts in drug discovery and development, this book sets forth carefully researched and analyzed case studies of both successful and failed drug discovery and development efforts, enabling medicinal chemists and pharmaceutical scientists to learn from actual examples. Each case study focuses on a particular drug and therapeutic target, guiding readers through the drug discovery and development process, including drug design rationale, structure-activity relationships, pharmacology, drug metabolism, biology, and clinical studies. Case Studies in Modern Drug Discovery and Development begins with an introductory chapter that puts into perspective the underlying issues facing the pharmaceutical industry and provides insight into future research opportunities. Next, there are fourteen detailed case studies, examining: All phases of drug discovery and development from initial idea to commercialization Some of today's most important and life-saving medications Drugs designed for different therapeutic areas such as cardiovascular disease, infection, inflammation, cancer, metabolic syndrome, and allergies Examples of prodrugs and inhaled drugs Reasons why certain drugs failed to advance to market despite major research investments Each chapter ends with a list of references leading to the primary literature. There are also plenty of tables and illustrations to help readers fully understand key concepts, processes, and technologies. Improving the success rate of the drug discovery and development process is paramount to the pharmaceutical industry. With this book as their guide, readers can learn from both successful and unsuccessful efforts in order to apply tested and proven science and technologies that increase the probability of success for new drug discovery and development projects.
Author: Stefan Bräse
Publisher: Royal Society of Chemistry
ISBN: 1782620303
Category : Medical
Languages : en
Pages : 486
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Book Description
This book addresses the various classes of privileged scaffolds and covers the history of their discovery and use.
Author: Bimal Banik
Publisher: Elsevier
ISBN: 0443161674
Category : Science
Languages : en
Pages : 699
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Book Description
Extensive experimentation and high failure rates are a well-recognized downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry 2e reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry, Second Edition encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work. This second volume of the second edition includes the development of nanoparticles and nanocomposites, as well as the application of ultrasound and microwave-induced methods; studies solventless synthesis; defines the role of steroids; studies reactions in aqueous solution; identifies enzyme-mediated reactions; investigates ionic liquids and deep eutectic solvents; explores natural products; investigates solid supports; realizes the effects of salts; focuses on combinatorial chemistry; develops one-pot methods; analyzes multi-component reactions; investigates dipole moment values; and examines computer-assisted methods. - Highlights the need for adoption of sustainable and green chemistry pathways in drug development - Reveals risk factors associated with the drug development process and the ways sustainable approaches can help address these - Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability
Author: Asha Kumari
Publisher: Elsevier
ISBN: 0443153493
Category : Science
Languages : en
Pages : 243
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Book Description
Sweet Biochemistry: Remembering Structures, Cycles, and Pathways by Mnemonics, Second Edition makes biochemistry lively, interesting and memorable by connecting objects, images and stories to biochemistry concepts. Here, Dr. Asha Kumari has converted cycles and difficult pathways into very simple formula and short stories and images to help readers see things in complicated cycles and better visualize biochemistry. As biochemistry is evolving steadily, with new and impactful topics, this new edition has been fully updated to include mnemonics on timely topics in biochemistry such as DNA replication, RNA, transcription, translation, and CRISPR technology, as well as fundamentals of immunity. - Provides quick, indigenous formula, mnemonics, figures, poems and short stories to absorb key concepts in biochemistry - Presents original diagrams that are easy to recall - Features simplified tables for remembering distinguishing features - Updated to address evolving topics in basic and medical biochemistry, including DNA replication, RNA transcription and translation and immunity fundamentals
Author: Stefano Crespi
Publisher: Royal Society of Chemistry
ISBN: 183916526X
Category : Science
Languages : en
Pages : 507
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Book Description
Providing critical analysis of emerging and well-established topics, this book is essential reading for anyone wanting to keep up to date with the literature on photochemistry and its applications. Volume 49 combines reviews on the latest advances in photochemical research with specific highlights in the field. The first section includes periodical reports of the recent literature on physical and inorganic aspects, including reviews of the molecules employed as dyes in art, light induced reactions in cryogenic matrices, photobiological systems studied by time-resolved infrared spectroscopy and photophysics, and photochemistry of transition metal complexes. This selection is completed by reviews of the literature on solar photocatalysis for water decontamination and disinfection and for water splitting/hydrogen production. Coverage continues in the second part with highlighted topics, from the use of aromatic carbonyls as photocatalysts and photoinitiators in synthesis, photoinduced and photocatalysed decarboxylation reactions, development of dye-sensitized solar cells, design of luminescent water-soluble systems, and applications of plasmonic nanoparticles. This volume also includes a third section entitled ‘SPR Lectures on Photochemistry’, where leading scientists in photochemistry provide examples to introduce a photochemical topic to academic readers, offering precious assistance to students in this field.
Author: Orazio A. Attanasi
Publisher:
ISBN: 9788886208567
Category : Science
Languages : en
Pages : 0
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Book Description
Volume 11 keeps the international standard of the THS series, covering the synthesis, reactivity, activity (including medicinal) and mass spectrometry of different systems.
