Retroviral Proteases

Retroviral Proteases PDF Author: Lawrence C. Kuo
Publisher: Gulf Professional Publishing
ISBN: 9780121821425
Category : Medical
Languages : en
Pages : 494

Get Book Here

Book Description
Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.

Retroviral Proteases

Retroviral Proteases PDF Author: Lawrence C. Kuo
Publisher: Gulf Professional Publishing
ISBN: 9780121821425
Category : Medical
Languages : en
Pages : 494

Get Book Here

Book Description
Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.

Viral Proteases and Their Inhibitors

Viral Proteases and Their Inhibitors PDF Author: Satya Prakash Gupta
Publisher: Academic Press
ISBN: 0128096829
Category : Science
Languages : en
Pages : 518

Get Book Here

Book Description
Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents. Provides comprehensive, state-of-the-art coverage of virus infections, the virus lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of each viral protease Presents an in-depth view of the structure and function of viral proteases

Encyclopedia of Molecular Pharmacology

Encyclopedia of Molecular Pharmacology PDF Author: Stefan Offermanns
Publisher: Springer Science & Business Media
ISBN: 3540389164
Category : Medical
Languages : en
Pages : 1515

Get Book Here

Book Description
An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

Retroviruses

Retroviruses PDF Author: John M. Coffin
Publisher: CSHL Press
ISBN: 9780879695712
Category : Medical
Languages : en
Pages : 856

Get Book Here

Book Description
For over 25 years the study of retroviruses has underpinned much of what is known about information transfer in cells and the genetic and biochemical mechanisms that underlie cell growth and cancer induction. Emergent diseases such as AIDS and adult T-cell lymphoma have widened even further the community of investigators directly concerned with retroviruses, a development that has highlighted the need for an integrated understanding of their biology and their unique association with host genomes. This remarkable volume satisfies that need. Written by a group of the field's most distinguished investigators, rigorously edited to provide a seamless narrative, and elegantly designed for clarity and readability, this book is an instant classic that demands attention from scientists and physicians studying retroviruses and the disorders in which they play a role.

Proteases of Retroviruses

Proteases of Retroviruses PDF Author: Vladimír Kostka
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110862786
Category : Science
Languages : en
Pages : 220

Get Book Here

Book Description
No detailed description available for "Proteases of Retroviruses".

HIV-1 Integrase

HIV-1 Integrase PDF Author: Nouri Neamati
Publisher: John Wiley & Sons
ISBN: 1118015363
Category : Science
Languages : en
Pages : 710

Get Book Here

Book Description
This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase.

Activation of Viruses by Host Proteases

Activation of Viruses by Host Proteases PDF Author: Eva Böttcher-Friebertshäuser
Publisher: Springer
ISBN: 3319754742
Category : Medical
Languages : en
Pages : 337

Get Book Here

Book Description
This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.

RNA Tumor Viruses: Supplements and appendixes

RNA Tumor Viruses: Supplements and appendixes PDF Author:
Publisher:
ISBN:
Category : Oncogenic viruses
Languages : en
Pages : 1254

Get Book Here

Book Description


Proteases as Targets for Therapy

Proteases as Targets for Therapy PDF Author: Klaus von der Helm
Publisher: Springer Science & Business Media
ISBN: 9783540661184
Category : Medical
Languages : en
Pages : 440

Get Book Here

Book Description
This volume is the first to combine latest information on viral, microbial and cellular proteolytic enzymes as potential targets for human therapeutics. Proteases control a large array of physiological reactions, and are involved in a variety of pathological processes for which effective medications are currently needed and/or being sought after. Although protease inhibitors have been investigated for many years, few have been employed therapeutically. Recent break- through by HIV protease inhibitors as therapeutic drugs has re-encouraged the search for inhibitors of other proteolytic enzymes. Klaus von der Helm, who described the first viral protease has brought leading experts together to discuss not only the success and problems of clinical use and continuing prospects, but to review further potential drug targets. This volume provides detailed information and evaluations of key viral, bacterial, fungal, and cellular proteases as potential future drug candidates.

Foamy Viruses

Foamy Viruses PDF Author: Axel Rethwilm
Publisher: Springer Science & Business Media
ISBN: 9783540443889
Category : Medical
Languages : en
Pages : 232

Get Book Here

Book Description
The aberrant replication pathway of foamy viruses distinguishes them from all other retroviruses. Many details have been accumulated over the past ten or so years. Most of the findings on foamy viruses were obtained by research on a single virus isolate previously called "human foamy virus", which appeared to be the first to be investigated on a molecular level. However, to the editor's knowledge, genuine human foamy viruses do not exist, but several trans-species transmissions of different simian foamy viruses from monkeys and apes to human hosts.