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Author: Mieczyslaw Pokorski
Publisher: Springer
ISBN: 3319351044
Category : Medical
Languages : en
Pages : 98
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Book Description
Good health and medical care in childhood and adolescence are essential for the ability to neutralize health threats later in life and to extend longevity. Thus, pediatric diseases, diagnostics and treatment justifiably draw ever increasing attention. The book highlights recent advances and innovations in gastroesophageal ailments, often missed in children, respiratory infections, and in genetically determined immune malfunctions such as familial hemophagocytic lymphohistiocytosis, known as a cytokine storm, renal vasculitis, or thyroid and growth anomalies. Functional genomics has become part of genetic counseling aimed at early diagnosis and treatment of chromosomal aberrations underlying congenital malformations. Deeper insights into childhood morbidity require identification of the pathways and biological processes most affected which could become drug targets. This book is dedicated to practical aspects of multifactorial disease processes of young age. It will be of interest to pediatricians, family doctors, and clinical researchers.
Author: Mieczyslaw Pokorski
Publisher: Springer
ISBN: 3319351044
Category : Medical
Languages : en
Pages : 98
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Book Description
Good health and medical care in childhood and adolescence are essential for the ability to neutralize health threats later in life and to extend longevity. Thus, pediatric diseases, diagnostics and treatment justifiably draw ever increasing attention. The book highlights recent advances and innovations in gastroesophageal ailments, often missed in children, respiratory infections, and in genetically determined immune malfunctions such as familial hemophagocytic lymphohistiocytosis, known as a cytokine storm, renal vasculitis, or thyroid and growth anomalies. Functional genomics has become part of genetic counseling aimed at early diagnosis and treatment of chromosomal aberrations underlying congenital malformations. Deeper insights into childhood morbidity require identification of the pathways and biological processes most affected which could become drug targets. This book is dedicated to practical aspects of multifactorial disease processes of young age. It will be of interest to pediatricians, family doctors, and clinical researchers.
Author: Andrew E. Mulberg
Publisher: John Wiley & Sons
ISBN: 1118210433
Category : Medical
Languages : en
Pages : 843
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Book Description
Pediatric Drug Development: Concepts and Applications is designed as a reference and textbook and is meant to address the science of differences between the pediatric and adult subject in the development of pharmaceutical products. Considered are the ethics and medical needs of proper understanding the pediatric and adult differences, the business case for proper development of drugs for children, as well as the technical feasibility studies and processes that are necessary for a proper pediatric drug development program. The applications of these approaches will benefit all stakeholders and ultimately not only educate but also provide better and safer drugs for pediatric patients.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309225493
Category : Medical
Languages : en
Pages : 432
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Book Description
The Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA) were designed to encourage more pediatric studies of drugs used for children. The FDA asked the IOM to review aspects of pediatric studies and changes in product labeling that resulted from BPCA and PREA and their predecessor policies, as well as assess the incentives for pediatric studies of biologics and the extent to which biologics have been studied in children. The IOM committee concludes that these policies have helped provide clinicians who care for children with better information about the efficacy, safety, and appropriate prescribing of drugs. The IOM suggests that more can be done to increase knowledge about drugs used by children and thereby improve the clinical care, health, and well-being of the nation's children.
Author: Tomoaki Taguchi
Publisher: Springer
ISBN: 9811336067
Category : Medical
Languages : en
Pages : 292
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Book Description
This book provides essential information on the status quo and changing profile of Hirschsprung’s disease and allied disorders. Hirschsprung’s disease is a common cause of neonatal intestinal obstruction and one of the most important and most fascinating diseases in pediatric surgery throughout the world. Currently, the diagnosis and treatment of Hirschsprung’s disease and allied disorders are in a state of constant development. Written by expert pediatric surgeons, Hirschsprung’s Disease and the Allied Disorders presents state-of-the-art information, such as new genetic evidence, and historical operative techniques that were less invasive and resulted in fewer follow-up operations. It offers a highly informative guide that will greatly benefit all readers engaged in pediatric medicine, pediatric surgeons, and the medical staff of NICUs around the globe.
Author: Andrew E. Mulberg
Publisher: John Wiley & Sons
ISBN: 1118312058
Category : Medical
Languages : en
Pages : 782
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Book Description
Most medicines have never been adequately tested for safety and efficacy in pediatric populations and preterm, infants and children are particularly vulnerable to adverse drug reactions. Pediatric Drug Development: Concepts and Applications, Second Edition, addresses the unique challenges in conducting effective drug research and development in pediatric populations. This new edition covers the legal and ethical issues of consent and assent, the additional legal and safety protections for children, and the appropriate methods of surveillance and assessment for children of varying ages and maturity, particularly for patient reported outcomes. It includes new developments in biomarkers and surrogate endpoints, developmental pharmacology and other novel aspects of global pediatric drug development. It also encompasses the new regulatory initiatives across EU, US and ROW designed to encourage improved access to safe and effective medicines for children globally. From an international team of expert contributors Pediatric Drug Development: Concepts and Applications is the practical guide to all aspects of the research and development of safe and effective medicines for children.
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241546700
Category : Medical
Languages : en
Pages : 399
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Book Description
This pocket book contains up-to-date clinical guidelines, based on available published evidence by subject experts, for both inpatient and outpatient care in small hospitals where basic laboratory facilities and essential drugs and inexpensive medicines are available. It is for use by doctors, senior nurses and other senior health workers who are responsible for the care of young children at the first referral level in developing countries. In some settings, these guidelines can be used in the larger health centres where a small number of sick children can be admitted for inpatient care.
Author: Tomoaki Taguchi
Publisher:
ISBN: 9789811336072
Category : Hirschsprung's disease
Languages : en
Pages :
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Book Description
This book provides essential information on the status quo and changing profile of Hirschsprung's disease and allied disorders. Hirschsprung's disease is a common cause of neonatal intestinal obstruction and one of the most important and most fascinating diseases in pediatric surgery throughout the world. Currently, the diagnosis and treatment of Hirschsprung's disease and allied disorders are in a state of constant development. Written by expert pediatric surgeons, Hirschsprung's Disease and the Allied Disorders presents state-of-the-art information, such as new genetic evidence, and historical operative techniques that were less invasive and resulted in fewer follow-up operations. It offers a highly informative guide that will greatly benefit all readers engaged in pediatric medicine, pediatric surgeons, and the medical staff of NICUs around the globe.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309133386
Category : Medical
Languages : en
Pages : 445
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Book Description
In recent decades, advances in biomedical research have helped save or lengthen the lives of children around the world. With improved therapies, child and adolescent mortality rates have decreased significantly in the last half century. Despite these advances, pediatricians and others argue that children have not shared equally with adults in biomedical advances. Even though we want children to benefit from the dramatic and accelerating rate of progress in medical care that has been fueled by scientific research, we do not want to place children at risk of being harmed by participating in clinical studies. Ethical Conduct of Clinical Research Involving Children considers the necessities and challenges of this type of research and reviews the ethical and legal standards for conducting it. It also considers problems with the interpretation and application of these standards and conduct, concluding that while children should not be excluded from potentially beneficial clinical studies, some research that is ethically permissible for adults is not acceptable for children, who usually do not have the legal capacity or maturity to make informed decisions about research participation. The book looks at the need for appropriate pediatric expertise at all stages of the design, review, and conduct of a research project to effectively implement policies to protect children. It argues persuasively that a robust system for protecting human research participants in general is a necessary foundation for protecting child research participants in particular.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309166608
Category : Social Science
Languages : en
Pages : 336
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Book Description
Children's health has clearly improved over the past several decades. Significant and positive gains have been made in lowering rates of infant mortality and morbidity from infectious diseases and accidental causes, improved access to health care, and reduction in the effects of environmental contaminants such as lead. Yet major questions still remain about how to assess the status of children's health, what factors should be monitored, and the appropriate measurement tools that should be used. Children's Health, the Nation's Wealth: Assessing and Improving Child Health provides a detailed examination of the information about children's health that is needed to help policy makers and program providers at the federal, state, and local levels. In order to improve children's health-and, thus, the health of future generations-it is critical to have data that can be used to assess both current conditions and possible future threats to children's health. This compelling book describes what is known about the health of children and what is needed to expand the knowledge. By strategically improving the health of children, we ensure healthier future generations to come.
Author: Charles Hunter Dunn
Publisher:
ISBN:
Category : Children
Languages : en
Pages : 708
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Book Description
