Principles of Route-to-route Extrapolation for Risk Assessment

Principles of Route-to-route Extrapolation for Risk Assessment PDF Author: Timothy R. Gerrity
Publisher: Elsevier Publishing Company
ISBN: 9780444015822
Category : Dose-response relationship (Biochemistry)
Languages : en
Pages : 322

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Book Description

Principles of Route-to-route Extrapolation for Risk Assessment

Principles of Route-to-route Extrapolation for Risk Assessment PDF Author: Timothy R. Gerrity
Publisher: Elsevier Publishing Company
ISBN: 9780444015822
Category : Dose-response relationship (Biochemistry)
Languages : en
Pages : 322

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Book Description


Risk Assessment of Chemicals: An Introduction

Risk Assessment of Chemicals: An Introduction PDF Author: C.J. van Leeuwen
Publisher: Springer Science & Business Media
ISBN: 1402061013
Category : Science
Languages : en
Pages : 706

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Book Description
At last – a second edition of this hugely important text that reflects the progress and experience gained in the last decade and aims at providing background and training material for a new generation of risk assessors. The authors offer an introduction to risk assessment of chemicals as well as basic background information on sources, emissions, distribution and fate processes for the estimation of exposure of plant and animal species in the environment and humans exposed via the environment, consumer products, and at the workplace. The coverage describes the basic principles and methods of risk assessment within their legislative frameworks (EU, USA, Japan and Canada).

Drinking Water and Health, Volume 8

Drinking Water and Health, Volume 8 PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309037751
Category : Nature
Languages : en
Pages : 507

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Book Description
Pharmacokinetics, the study of the movement of chemicals within the body, is a vital tool in assessing the risk of exposure to environmental chemicals. This bookâ€"a collection of papers authored by experts in academia, industry, and governmentâ€"reviews the progress of the risk-assessment process and discusses the role of pharmacokinetic principles in evaluating risk. In addition, the authors discuss software packages used to analyze data and to build models simulating biological phenomena. A summary chapter provides a view of trends in pharmacokinetic modeling and notes some prospective fields of study.

Drinking Water and Health,

Drinking Water and Health, PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309036879
Category : Nature
Languages : en
Pages : 476

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Book Description
The most recent volume in the Drinking Water and Health series contains the results of a two-part study on the toxicity of drinking water contaminants. The first part examines current practices in risk assessment, identifies new noncancerous toxic responses to chemicals found in drinking water, and discusses the use of pharmacokinetic data to estimate the delivered dose and response. The second part of the book provides risk assessments for 14 specific compounds, 9 presented here for the first time.

Science and Judgment in Risk Assessment

Science and Judgment in Risk Assessment PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 030904894X
Category : Science
Languages : en
Pages : 668

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Book Description
The public depends on competent risk assessment from the federal government and the scientific community to grapple with the threat of pollution. When risk reports turn out to be overblownâ€"or when risks are overlookedâ€"public skepticism abounds. This comprehensive and readable book explores how the U.S. Environmental Protection Agency (EPA) can improve its risk assessment practices, with a focus on implementation of the 1990 Clean Air Act Amendments. With a wealth of detailed information, pertinent examples, and revealing analysis, the volume explores the "default option" and other basic concepts. It offers two views of EPA operations: The first examines how EPA currently assesses exposure to hazardous air pollutants, evaluates the toxicity of a substance, and characterizes the risk to the public. The second, more holistic, view explores how EPA can improve in several critical areas of risk assessment by focusing on cross-cutting themes and incorporating more scientific judgment. This comprehensive volume will be important to the EPA and other agencies, risk managers, environmental advocates, scientists, faculty, students, and concerned individuals.

Science and Decisions

Science and Decisions PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309120462
Category : Political Science
Languages : en
Pages : 422

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Book Description
Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.

Risk Assessment for Chemicals in Drinking Water

Risk Assessment for Chemicals in Drinking Water PDF Author: Robert A. Howd
Publisher: John Wiley & Sons
ISBN: 0470173378
Category : Science
Languages : en
Pages : 392

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Book Description
A comprehensive reference on state-of-the-art risk assessment methodologies for drinking water Risk Assessment for Chemicals in Drinking Water discusses the major steps and goals in risk assessments and suggests ways to improve the methodologies and accuracy, while consolidating up-to-date information on the current principles and practices in one authoritative reference. After an enlightening overview of risk assessment practices and regulatory guidelines, it: Includes descriptions of the use of variability analysis, exposure analysis, physiologically based pharmacokinetics, and modeling for both cancer and non-cancer endpoints Describes the practices of major organizations, including the U.S. EPA, Health Canada, World Health Organization, and California Office of Environmental Health Hazard Assessment Includes complete chapters on risk assessment for essential nutrients, arsenic, chloroform, and perchlorate Explains how to address susceptible sub-populations, including the elderly and infants and children, in risk assessments Covers the potential of using genomic and proteomic screens Addresses recent advances, emerging issues, and future challenges With contributions and perspectives from leading scientists, this is the definitive resource for health and environmental scientists, toxicologists, risk assessors and managers, regulators, consultants, and other professionals responsible for the safety of drinking water.

Principles of Route-To-Route Extrapolation for Risk Assessment

Principles of Route-To-Route Extrapolation for Risk Assessment PDF Author: Timothy Gerrity
Publisher: Appleton & Lange
ISBN: 9780135006047
Category : Medical
Languages : en
Pages :

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Book Description


Risk Assessment Guidance for Superfund: pt. A. Human health evaluation manual

Risk Assessment Guidance for Superfund: pt. A. Human health evaluation manual PDF Author:
Publisher:
ISBN:
Category : Hazardous substances
Languages : en
Pages : 300

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Book Description


An Examination of EPA Risk Assessment Principles and Practices

An Examination of EPA Risk Assessment Principles and Practices PDF Author: United States. Environmental Protection Agency. Risk Assessment Task Force
Publisher:
ISBN:
Category : Environmental risk assessment
Languages : en
Pages : 204

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Book Description