Precision Medicine and Immuno-Mediated Inflammatory Diseases: Latest Progress and Next Challenges PDF Download
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Author: Luca Antonioli
Publisher: Frontiers Media SA
ISBN: 2889746291
Category : Science
Languages : en
Pages : 175
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Book Description
Author: Luca Antonioli
Publisher: Frontiers Media SA
ISBN: 2889746291
Category : Science
Languages : en
Pages : 175
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Book Description
Author: Sonia Dagnino
Publisher: Springer
ISBN: 3319893211
Category : Medical
Languages : en
Pages : 445
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Book Description
This volume presents a comprehensive overview of the science and application of the Exposome through seventeen chapters from leaders in the field. At just over ten years since the term was coined by Christopher Wild in 2005, this is the first, field-defining volume to offer a holistic picture of the important and growing field of Exposomics. The term “Exposome” describes the sum of all exposures (not only chemical) that an individual can receive over a lifetime from both exogenous sources (environmental contaminants, food, lifestyle, drugs, air, etc.) and endogenous sources (metabolism, oxidative stress, lipid peroxidation, chemicals synthesized by the microbiome, etc.). The first section of this book contains chapters that discuss how the Exposome is defined and how the concept fits into the fields of public health and epidemiology. The second section provides an overview of techniques and methods to measure the human Exposome. The third section contains methods and applications for measuring the Exposome through external exposures. Section four provides an overview on statistical and computational techniques- including big data analysis - for characterizing the Exposome. Section five presents a global collection of case studies
Author: Shay Soker
Publisher: Humana Press
ISBN: 3319605119
Category : Medical
Languages : en
Pages : 225
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Book Description
Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.
Author: Xu-jie Zhou
Publisher: Frontiers Media SA
ISBN: 2889765830
Category : Medical
Languages : en
Pages : 227
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Book Description
Topic Editor Dr. MacLeod is employed by Janssen. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Author: Janusz Kacprzyk
Publisher: Springer Nature
ISBN: 3031352483
Category : Technology & Engineering
Languages : en
Pages : 882
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Book Description
This book describes the potential contributions of emerging technologies in different fields as well as the opportunities and challenges related to the integration of these technologies in the socio-economic sector. In this book, many latest technologies are addressed, particularly in the fields of computer science and engineering. The expected scientific papers covered state-of-the-art technologies, theoretical concepts, standards, product implementation, ongoing research projects, and innovative applications of Sustainable Development. This new technology highlights, the guiding principle of innovation for harnessing frontier technologies and taking full profit from the current technological revolution to reduce gaps that hold back truly inclusive and sustainable development. The fundamental and specific topics are Big Data Analytics, Wireless sensors, IoT, Geospatial technology, Engineering and Mechanization, Modeling Tools, Risk analytics, and preventive systems.
Author: Garifallia Sakellariou
Publisher: Frontiers Media SA
ISBN: 2832504086
Category : Medical
Languages : en
Pages : 112
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Book Description
Author: Dr. Spineanu Eugenia
Publisher: Dr. Spineanu Eugenia
ISBN:
Category : Medical
Languages : en
Pages : 127
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Book Description
Embark on a journey through the intricate world of neonatal anemia with our treatise, "Neonatal Anemia: Unraveling the Hematological Tapestry of New Beginnings." This comprehensive work delves into the complexities of anemia in newborns, offering an in-depth exploration of medical, genetic, nutritional, and environmental factors that shape the landscape of neonatal hematopoiesis. From the earliest stages of fetal development, where the production of vital fetal hemoglobin takes center stage, to the dynamic processes of erythropoiesis within the fetal liver and bone marrow, our treatise navigates the fascinating biological events shaping neonatal red blood cell formation. The pivotal role of the placenta in oxygenation and hematopoiesis adds a layer of understanding to the intricate dance of life in utero. Delving deeper, we unravel the genetic intricacies of inherited hemoglobinopathies, exploring both alpha and beta thalassemia in meticulous detail. Nutritional deficiencies, including iron, folate, and vitamin B12, emerge as significant contributors to neonatal anemia, highlighting the critical role of maternal nutrition in ensuring optimal fetal development. But our exploration doesn't stop at genetics and nutrition. We venture into the realm of environmental influences, dissecting the impact of prenatal exposures, air and water quality, and maternal lifestyle choices on neonatal hematological health. The treatise underscores the importance of recognizing and addressing these environmental determinants for comprehensive neonatal care.
Author: Alessio Martino
Publisher: Frontiers Media SA
ISBN: 2832502229
Category : Medical
Languages : en
Pages : 128
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Book Description
Author:
Publisher: Elsevier
ISBN: 0323900658
Category : Medical
Languages : en
Pages : 394
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Book Description
Precision Medicine in Neurodegenerative Disorders, Part Two, Volume 193 in the Handbook of Clinical Neurology deals with the "How" in the reconfiguration of our approach to slow accelerated brain aging. The book rethinks animal models on which therapies are tested, outlines the progress and expected changes in biological subtyping efforts using lysosomal, endosomal, mitochondrial, immune dysregulation, and inflammatory mechanisms of disease pathophysiology, and the growing role of microbiome in shaping disease. The volume separates the potentially disease-modifying neurorescue and neurorestoration, (e.g., gene therapy and cell replacement therapy) from true precision "medicine"–matching biology with the mechanism of intervention of interest. Specific chapters are dedicated to the promise and challenges of extracellular vesicles for both diagnosis and treatment, the growing application of digital measures and other evaluations of clinical response, the nuts and bolts of novel adaptive clinical trial designs, and the regulatory changes needed to facilitate drug development for disease-modification purposes. - Summarizes theory and research on precision medicine in neurodegenerative disorders - Covers basic biology, clinical trials and therapeutics - Includes disease mechanisms, genetic subtypes, and more
Author: Mariana Quezado
Publisher: Frontiers Media SA
ISBN: 2832554083
Category : Science
Languages : en
Pages : 129
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Book Description
Precision medicine, or personalized medicine, is related to treatment based on the patient’s individual characteristics. To promote this personalized approach, diseases must accurately be diagnosed; specific biomarkers can predict disease evolution and optimize therapy based on each patient's characteristics such as their genetic background, lifestyle and environmental risk factors. Over the years, we have seen a revolution in pharmacotherapy and management of patients receiving personalized medicine, especially when we consider immunotherapy and specific tyrosine kinases inhibitors. Patients with inflammatory diseases, such as monogenetic diabetes and chronic kidney disease, have benefited from the progress made within the last decade related to our understanding of the genetic basis of diabetes. Similarly, patients in precision oncology, with breast, prostate and blood cancer have experienced better overall survival rates with targeted therapy such as trastuzumab (breast cancer), PARPs inhibitors (prostate cancer), imatinib, ibrutinib and venetoclax (leukemia).
