Pitfalls and Errors of HPLC in Pictures PDF Download
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Author: Veronika R. Meyer
Publisher: John Wiley & Sons
ISBN: 3527659129
Category : Science
Languages : en
Pages : 195
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Book Description
The third edition of this popular problem-solving guide for this widely-used method includes eleven completely new examples and several updated ones, adding up to 100 contributions about pitfalls and errors in HPLC. Each example is presented on a double page with the text on the left-hand and a fi gure on the right-hand side, true to the motto 'a picture says more than a thousand words'. In addition, the author presents essential fundamentals as well as helpful strategies, such as equipment tests or quality assurance processes. New in this edition * Variability of the standard deviation * Infl uence of the acid type and concentration in the eluent * Water as an unintentional additive in the mobile phase * Inadequate purity of mobile phase water * Incomplete degassing * Inadequate stabilization of the extraction solvent * Tailing of phosphate compounds in the presence of steel * Different detection properties of diastereomers * Detector overload in ELSD * System suitability test * From repeatability to reproducibility A must-have resource for all users - showing how to use HPLC efficiently and obtain reliable results.
Author: Veronika R. Meyer
Publisher: John Wiley & Sons
ISBN: 3527659129
Category : Science
Languages : en
Pages : 195
Get Book
Book Description
The third edition of this popular problem-solving guide for this widely-used method includes eleven completely new examples and several updated ones, adding up to 100 contributions about pitfalls and errors in HPLC. Each example is presented on a double page with the text on the left-hand and a fi gure on the right-hand side, true to the motto 'a picture says more than a thousand words'. In addition, the author presents essential fundamentals as well as helpful strategies, such as equipment tests or quality assurance processes. New in this edition * Variability of the standard deviation * Infl uence of the acid type and concentration in the eluent * Water as an unintentional additive in the mobile phase * Inadequate purity of mobile phase water * Incomplete degassing * Inadequate stabilization of the extraction solvent * Tailing of phosphate compounds in the presence of steel * Different detection properties of diastereomers * Detector overload in ELSD * System suitability test * From repeatability to reproducibility A must-have resource for all users - showing how to use HPLC efficiently and obtain reliable results.
Author: Veronika Meyer
Publisher: Wiley-VCH
ISBN:
Category : Science
Languages : en
Pages : 208
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Book Description
The complexity of the HPLC method allows on one side a wide variety of usage. On the other side it is also a source of possible errors. This book does not only list them, but illustrate them with concrete examples. The topics were presented in a clearly arranged style: a brief text with a corresponding figure. Chemists and laboratory assistants get here numerous hints how correct and reliable results could be transposed in daily laboratory work.
Author: James M. Miller
Publisher: John Wiley & Sons
ISBN: 0471980595
Category : Science
Languages : en
Pages : 518
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Book Description
The first edition of Chromatography: Concepts and Contrasts, published in 1988, was one of the first books to discuss all the different types of chromatography under one cover. The second edition continues with these principles but has been updated to include new chapters on sampling and sample preparation, capillary electrophoresis and capillary electrochromatography (CEC), chromatography with mass spec detection, and industrial and governmental practices in regulated industries. Covers extraction, solid phase extraction (SPE), and solid phase microextraction (SPME), and introduces mass spectrometry Updated with the latest techniques in chromatography Discusses both liquid chromatography (LC)and gas chromatography(GC)
Author: Günter J. Eppert
Publisher:
ISBN: 9783000108082
Category :
Languages : en
Pages : 156
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Book Description
Author: Chunlong Zhang
Publisher: John Wiley & Sons
ISBN: 0471710970
Category : Science
Languages : en
Pages : 459
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Book Description
An integrated approach to understanding the principles of sampling, chemical analysis, and instrumentation This unique reference focuses on the overall framework and why various methodologies are used in environmental sampling and analysis. An understanding of the underlying theories and principles empowers environmental professionals to select and adapt the proper sampling and analytical protocols for specific contaminants as well as for specific project applications. Covering both field sampling and laboratory analysis, Fundamentals of Environmental Sampling and Analysis includes: A review of the basic analytical and organic chemistry, statistics, hydrogeology, and environmental regulations relevant to sampling and analysis An overview of the fundamentals of environmental sampling design, sampling techniques, and quality assurance/quality control (QA/QC) essential to acquire quality environmental data A detailed discussion of: the theories of absorption spectroscopy for qualitative and quantitative environmental analysis; metal analysis using various atomic absorption and emission spectrometric methods; and the instrumental principles of common chromatographic and electrochemical methods An introduction to advanced analytical techniques, including various hyphenated mass spectrometries and nuclear magnetic resonance spectroscopy With real-life case studies that illustrate the principles plus problems and questions at the end of each chapter to solidify understanding, this is a practical, hands-on reference for practitioners and a great textbook for upper-level undergraduates and graduate students in environmental science and engineering.
Author: Stavros Kromidas
Publisher: John Wiley & Sons
ISBN: 3527694978
Category : Science
Languages : en
Pages : 384
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Book Description
How can I use my HPLC/UHPLC equipment in an optimal way, where are the limitations of the technique? These questions are discussed in detail in the sequel of the successful "HPLC Expert" in twelve chapters written by experts in the respective fields. The topics encompass - complementary to the first volume - typical HPLC users' problems and questions such as gradient optimization and hyphenated techniques (LC-MS). An important key aspect of the book is UHPLC: For which analytical problem is it essential, what should be considered? Besides presentation of latest developments directly from the main manufacturers, also UHPLC users and independent service engineers impart their knowledge. Consistent with the target groups, the level is advanced, but the emphasis is on practical applications.
Author: Joachim Ermer
Publisher: John Wiley & Sons
ISBN: 3527335633
Category : Medical
Languages : en
Pages : 451
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Book Description
This second edition of a global bestseller has been completely redesigned and extensively rewritten to take into account the new Quality by Design (QbD) and lifecycle concepts in pharmaceutical manufacturing. As in the first edition, the fundamental requirements for analytical method validation are covered, but the second edition describes how these are applied systematically throughout the entire analytical lifecycle. QbD principles require adoption of a systematic approach to development and validation that begin with predefined objectives. For analytical methods these predefined objectives are established as an Analytical Target Profile (ATP). The book chapters are aligned with recently introduced standards and guidelines for manufacturing processes validation and follow the three stages of the analytical lifecycle: Method Design, Method Performance Qualification, and Continued Method Performance Verification. Case studies and examples from the pharmaceutical industry illustrate the concepts and guidelines presented, and the standards and regulations from the US (FDA), European (EMA) and global (ICH) regulatory authorities are considered throughout. The undisputed gold standard in the field.
Author: Paul C. Sadek
Publisher: John Wiley & Sons
ISBN: 0471678805
Category : Science
Languages : en
Pages : 237
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Book Description
Provides concise definitions, illustrations, formulas, and all of the other information that you need in a laboratory chromatography reference The Illustrated Pocket Dictionary of Chromatography offers the perfect quick reference to the parameters, systems, and components that support successful chromatographic separations. Concise, practical, and filled with detailed drawings, diagrams, and photographs, this pocket dictionary is designed for easy use in the laboratory. It provides a complete, up-to-date reference on analytical techniques such as gas chromatography, high-performance liquid chromatography, thin layer chromatography, and capillary electrophoresis as well as preparation techniques such as solid phase extraction and microextraction. The Illustrated Pocket Dictionary of Chromatography features: Explanations of key concepts Equations and formulas Parameters High-quality photographs of instruments, equipment, and components References for further research Explanations of common acronyms Ideal for the working chemist or technician in pharmaceutical, industrial, forensic, government, or other lab settings, the Illustrated Pocket Dictionary of Chromatography is also appropriate as a supplemental reference for analytical chemistry courses and labs. Students and analysts alike will find this compact yet comprehensive resource a valuable companion to their work in chromatography.
Author: Sergio Petrozzi
Publisher: John Wiley & Sons
ISBN: 3527665919
Category : Science
Languages : en
Pages : 388
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Book Description
This practical book in instrumental analytics conveys an overview of important methods of analysis and enables the reader to realistically learn the (principally technology-independent) working techniques the analytical chemist uses to develop methods and conduct validation. What is to be conveyed to the student is the fact that analysts in their capacity as problem-solvers perform services for certain groups of customers, i.e., the solution to the problem should in any case be processed in such a way as to be "fit for purpose". The book presents sixteen experiments in analytical chemistry laboratory courses. They consist of the classical curriculum used at universities and universities of applied sciences with chromatographic procedures, atom spectrometric methods, sensors and special methods (e.g. field flow fractionation, flow injection analysis and N-determination according to Kjeldahl). The carefully chosen combination of theoretical description of the methods of analysis and the detailed instructions given are what characterizes this book. The instructions to the experiments are so detailed that the measurements can, for the most part, be taken without the help of additional literature. The book is complemented with tips for effective literature and database research on the topics of organization and the practical workflow of experiments in analytical laboratory, on the topic of the use of laboratory logs as well as on writing technical reports and grading them (Evaluation Guidelines for Laboratory Experiments). A small introduction to Quality Management, a brief glance at the history of analytical chemistry as well as a detailed appendix on the topic of safety in analytical laboratories and a short introduction to the new system of grading and marking chemicals using the "Globally Harmonized System of Classification and Labelling of Chemicals (GHS)", round off this book. This book is therefore an indispensable workbook for students, internship assistants and lecturers (in the area of chemistry, biotechnology, food technology and environmental technology) in the basic training program of analytics at universities and universities of applied sciences.
Author: Veronika R. Meyer
Publisher: John Wiley & Sons
ISBN: 1118681347
Category : Science
Languages : en
Pages : 342
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Book Description
Jump into the HPLC adventure! Three decades on from publication of the 1st German edition of Veronika Meyer's book on HPLC, this classic text remains one of the few titles available on general HPLC aimed at practitioners. New sections on the following topics have been included in this fifth edition: Comparison of HPLC with capillary electrophoresis How to obtain peak capacity van Deemter curves and other coherences Hydrophilic interaction chromatography Method transfer Comprehensive two-dimensional HPLC Fast separations at 1000 bar HPLC with superheated water In addition, two chapters on the instrument test and troubleshooting in the appendix have been updated and expanded by Bruno E. Lendi, and many details have been improved and numerous references added. A completely new chapter is presented on quality assurance covering: Is it worth the effort? Verification with a second method Method validation Standard operating procedures Measurement uncertainty Qualifications, instrument test, and system suitability test The quest for quality Reviews of earlier editions "That this text is written by an expert in both the practice and teaching of HPLC is evident from the first paragraph....not only an enjoyable, fascinating and easy read, but a truly excellent text that has and will serve many teachers, students and practitioners very well." —The Analyst “...provides essential information on HPLC for LC practitioners in academia, industry, government, and research laboratories...a valuable introduction." - American Journal of Therapeutics
