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Author: Diana Cole
Publisher: CRC Press
ISBN: 1498720900
Category : Mathematics
Languages : en
Pages : 273
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Book Description
Statistical and mathematical models are defined by parameters that describe different characteristics of those models. Ideally it would be possible to find parameter estimates for every parameter in that model, but, in some cases, this is not possible. For example, two parameters that only ever appear in the model as a product could not be estimated individually; only the product can be estimated. Such a model is said to be parameter redundant, or the parameters are described as non-identifiable. This book explains why parameter redundancy and non-identifiability is a problem and the different methods that can be used for detection, including in a Bayesian context. Key features of this book: Detailed discussion of the problems caused by parameter redundancy and non-identifiability Explanation of the different general methods for detecting parameter redundancy and non-identifiability, including symbolic algebra and numerical methods Chapter on Bayesian identifiability Throughout illustrative examples are used to clearly demonstrate each problem and method. Maple and R code are available for these examples More in-depth focus on the areas of discrete and continuous state-space models and ecological statistics, including methods that have been specifically developed for each of these areas This book is designed to make parameter redundancy and non-identifiability accessible and understandable to a wide audience from masters and PhD students to researchers, from mathematicians and statisticians to practitioners using mathematical or statistical models.
Author: Diana Cole
Publisher: CRC Press
ISBN: 1498720900
Category : Mathematics
Languages : en
Pages : 273
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Book Description
Statistical and mathematical models are defined by parameters that describe different characteristics of those models. Ideally it would be possible to find parameter estimates for every parameter in that model, but, in some cases, this is not possible. For example, two parameters that only ever appear in the model as a product could not be estimated individually; only the product can be estimated. Such a model is said to be parameter redundant, or the parameters are described as non-identifiable. This book explains why parameter redundancy and non-identifiability is a problem and the different methods that can be used for detection, including in a Bayesian context. Key features of this book: Detailed discussion of the problems caused by parameter redundancy and non-identifiability Explanation of the different general methods for detecting parameter redundancy and non-identifiability, including symbolic algebra and numerical methods Chapter on Bayesian identifiability Throughout illustrative examples are used to clearly demonstrate each problem and method. Maple and R code are available for these examples More in-depth focus on the areas of discrete and continuous state-space models and ecological statistics, including methods that have been specifically developed for each of these areas This book is designed to make parameter redundancy and non-identifiability accessible and understandable to a wide audience from masters and PhD students to researchers, from mathematicians and statisticians to practitioners using mathematical or statistical models.
Author: David L. Thomson
Publisher: Springer Science & Business Media
ISBN: 038778151X
Category : Medical
Languages : en
Pages : 1110
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Book Description
Here, biologists and statisticians come together in an interdisciplinary synthesis with the aim of developing new methods to overcome the most significant challenges and constraints faced by quantitative biologists seeking to model demographic rates.
Author: Marie Wiberg
Publisher: Springer Nature
ISBN: 3031555481
Category :
Languages : en
Pages : 385
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Book Description
Author: Rachel S. McCrea
Publisher: CRC Press
ISBN: 1439836604
Category : Mathematics
Languages : en
Pages : 302
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Book Description
An important first step in studying the demography of wild animals is to identify the animals uniquely through applying markings, such as rings, tags, and bands. Once the animals are encountered again, researchers can study different forms of capture-recapture data to estimate features, such as the mortality and size of the populations. Capture-rec
Author: Ralph C. Smith
Publisher: SIAM
ISBN: 1611977843
Category : Mathematics
Languages : en
Pages : 571
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Book Description
Uncertainty quantification serves a fundamental role when establishing the predictive capabilities of simulation models. This book provides a comprehensive and unified treatment of the mathematical, statistical, and computational theory and methods employed to quantify uncertainties associated with models from a wide range of applications. Expanded and reorganized, the second edition includes advances in the field and provides a comprehensive sensitivity analysis and uncertainty quantification framework for models from science and engineering. It contains new chapters on random field representations, observation models, parameter identifiability and influence, active subspace analysis, and statistical surrogate models, and a completely revised chapter on local sensitivity analysis. Other updates to the second edition are the inclusion of over 100 exercises and many new examples — several of which include data — and UQ Crimes listed throughout the text to identify common misconceptions and guide readers entering the field. Uncertainty Quantification: Theory, Implementation, and Applications, Second Edition is intended for advanced undergraduate and graduate students as well as researchers in mathematics, statistics, engineering, physical and biological sciences, operations research, and computer science. Readers are assumed to have a basic knowledge of probability, linear algebra, differential equations, and introductory numerical analysis. The book can be used as a primary text for a one-semester course on sensitivity analysis and uncertainty quantification or as a supplementary text for courses on surrogate and reduced-order model construction and parameter identifiability analysis.
Author: Aleš Prokop
Publisher: Springer Science & Business Media
ISBN: 9400768036
Category : Medical
Languages : en
Pages : 569
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Book Description
Growth in the pharmaceutical market has slowed down – almost to a standstill. One reason is that governments and other payers are cutting costs in a faltering world economy. But a more fundamental problem is the failure of major companies to discover, develop and market new drugs. Major drugs losing patent protection or being withdrawn from the market are simply not being replaced by new therapies – the pharmaceutical market model is no longer functioning effectively and most pharmaceutical companies are failing to produce the innovation needed for success. This multi-authored new book looks at a vital strategy which can bring innovation to a market in need of new ideas and new products: Systems Biology (SB). Modeling is a significant task of systems biology. SB aims to develop and use efficient algorithms, data structures, visualization and communication tools to orchestrate the integration of large quantities of biological data with the goal of computer modeling. It involves the use of computer simulations of biological systems, such as the networks of metabolites comprise signal transduction pathways and gene regulatory networks to both analyze and visualize the complex connections of these cellular processes. SB involves a series of operational protocols used for performing research, namely a cycle composed of theoretical, analytic or computational modeling to propose specific testable hypotheses about a biological system, experimental validation, and then using the newly acquired quantitative description of cells or cell processes to refine the computational model or theory.
Author: Claudio Cobelli
Publisher: Elsevier
ISBN: 0080559980
Category : Technology & Engineering
Languages : en
Pages : 337
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Book Description
This unified modeling textbook for students of biomedical engineering provides a complete course text on the foundations, theory and practice of modeling and simulation in physiology and medicine. It is dedicated to the needs of biomedical engineering and clinical students, supported by applied BME applications and examples. Developed for biomedical engineering and related courses: speaks to BME students at a level and in a language appropriate to their needs, with an interdisciplinary clinical/engineering approach, quantitative basis, and many applied examples to enhance learning Delivers a quantitative approach to modeling and also covers simulation: the perfect foundation text for studies across BME and medicine Extensive case studies and engineering applications from BME, plus end-of-chapter exercises
Author: K. B. Newman
Publisher: Springer
ISBN: 1493909770
Category : Medical
Languages : en
Pages : 223
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Book Description
This book gives a unifying framework for estimating the abundance of open populations: populations subject to births, deaths and movement, given imperfect measurements or samples of the populations. The focus is primarily on populations of vertebrates for which dynamics are typically modelled within the framework of an annual cycle, and for which stochastic variability in the demographic processes is usually modest. Discrete-time models are developed in which animals can be assigned to discrete states such as age class, gender, maturity, population (within a metapopulation), or species (for multi-species models). The book goes well beyond estimation of abundance, allowing inference on underlying population processes such as birth or recruitment, survival and movement. This requires the formulation and fitting of population dynamics models. The resulting fitted models yield both estimates of abundance and estimates of parameters characterizing the underlying processes.
Author: Bruce A. Tichenor
Publisher: ASTM International
ISBN: 0803120303
Category : Indoor air pollution
Languages : en
Pages : 408
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Book Description
Based on presentations at a 1994 Symposium, these detailed papers review source/sink characterization; design, construction, characterization, and operation of test chambers and facilities; testing protocols for determining emission factors and sink absorption/desorption rates; models for predicting
Author: George A. F. Seber
Publisher: Springer
ISBN: 3030181871
Category : Mathematics
Languages : en
Pages : 669
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Book Description
This comprehensive book, rich with applications, offers a quantitative framework for the analysis of the various capture-recapture models for open animal populations, while also addressing associated computational methods. The state of our wildlife populations provides a litmus test for the state of our environment, especially in light of global warming and the increasing pollution of our land, seas, and air. In addition to monitoring our food resources such as fisheries, we need to protect endangered species from the effects of human activities (e.g. rhinos, whales, or encroachments on the habitat of orangutans). Pests must be be controlled, whether insects or viruses, and we need to cope with growing feral populations such as opossums, rabbits, and pigs. Accordingly, we need to obtain information about a given population’s dynamics, concerning e.g. mortality, birth, growth, breeding, sex, and migration, and determine whether the respective population is increasing , static, or declining. There are many methods for obtaining population information, but the most useful (and most work-intensive) is generically known as “capture-recapture,” where we mark or tag a representative sample of individuals from the population and follow that sample over time using recaptures, resightings, or dead recoveries. Marks can be natural, such as stripes, fin profiles, and even DNA; or artificial, such as spots on insects. Attached tags can, for example, be simple bands or streamers, or more sophisticated variants such as radio and sonic transmitters. To estimate population parameters, sophisticated and complex mathematical models have been devised on the basis of recapture information and computer packages. This book addresses the analysis of such models. It is primarily intended for ecologists and wildlife managers who wish to apply the methods to the types of problems discussed above, though it will also benefit researchers and graduate students in ecology. Familiarity with basic statistical concepts is essential.
