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Author: Kan He
Publisher: Elsevier
ISBN: 0128173394
Category : Medical
Languages : en
Pages : 448
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Book Description
Overcoming Obstacles in Drug Discovery and Development uses real-world case studies to illustrate how critical thinking and problem solving skills are applied in the discovery and development of drugs. It also shows how developing critical thinking to overcome issues plays an essential role in the process. Modern drug discovery and development is a highly complex undertaking that requires scientific and professional expertise to be successful. After the identification of a molecular entity for treating a medical condition, challenges inevitably arise during the subsequent development to understand and characterize the biological profile; feedback from scientists is used to fine-tune the molecular entity to obtain an effective and safe product. In this process, the discovery team may identify unexpected safety issues and new medical disorders for treatment by the molecular entity. Invariably inherent in this complex undertaking are miscues, mistakes, and unexpected problems that can derail development and throw timetables into disarray, potentially leading to failure in the development of a medically useful drug. Addressing critical unexpected problems during development often requires scientists to utilize critical thinking and imaginative problem-solving skills. Overcoming Obstacles in Drug Discovery and Development will be essential to young scientists to help learn the skills to successfully face challenges, learn from mistakes, and further develop critical thinking skills. It will also be beneficial to experienced researchers who can learn from the case studies of successful and unsuccessful drug development. - Provides real-world case studies in drug discovery and the development of drugs - Illustrates the use of critical thinking and problem solving in approaching preclinical and clinical problems in drug discovery and development - Illustrates and analyses examples of successes and failures in drug discovery and development that have not previously been reported
Author: Kan He
Publisher: Elsevier
ISBN: 0128173394
Category : Medical
Languages : en
Pages : 448
Get Book Here
Book Description
Overcoming Obstacles in Drug Discovery and Development uses real-world case studies to illustrate how critical thinking and problem solving skills are applied in the discovery and development of drugs. It also shows how developing critical thinking to overcome issues plays an essential role in the process. Modern drug discovery and development is a highly complex undertaking that requires scientific and professional expertise to be successful. After the identification of a molecular entity for treating a medical condition, challenges inevitably arise during the subsequent development to understand and characterize the biological profile; feedback from scientists is used to fine-tune the molecular entity to obtain an effective and safe product. In this process, the discovery team may identify unexpected safety issues and new medical disorders for treatment by the molecular entity. Invariably inherent in this complex undertaking are miscues, mistakes, and unexpected problems that can derail development and throw timetables into disarray, potentially leading to failure in the development of a medically useful drug. Addressing critical unexpected problems during development often requires scientists to utilize critical thinking and imaginative problem-solving skills. Overcoming Obstacles in Drug Discovery and Development will be essential to young scientists to help learn the skills to successfully face challenges, learn from mistakes, and further develop critical thinking skills. It will also be beneficial to experienced researchers who can learn from the case studies of successful and unsuccessful drug development. - Provides real-world case studies in drug discovery and the development of drugs - Illustrates the use of critical thinking and problem solving in approaching preclinical and clinical problems in drug discovery and development - Illustrates and analyses examples of successes and failures in drug discovery and development that have not previously been reported
Author: Alexandros Makriyannis
Publisher: CRC Press
ISBN: 082475767X
Category : Medical
Languages : en
Pages : 317
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Book Description
Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods-a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimization, and biological testing. This volume addresses challenges encountered during the discovery of new pharmaceutical candidates including the use of cutting-edge techniques utilized in drug design and development. It considers key elements in the drug design cycle ranging from appropriateness of targets and disease models to compound characterization, safety, and efficacy and the role of protein crystallography in structure-based drug design.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309169712
Category : Science
Languages : en
Pages : 130
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Book Description
Dramatic developments in understanding the fundamental underpinnings of life have provided exciting opportunities to make marine bioproducts an important part of the U.S. economy. Several marine based pharmaceuticals are under active commercial development, ecosystem health is high on the public's list of concerns, and aquaculture is providing an ever greater proportion of the seafood on our tables. Nevertheless, marine biotechnology has not yet caught the public's, or investor's, attention. Two workshops, held in October 1999 and November 2001 at the National Academies, were successful in highlighting new developments and opportunities in environmental and biomedical applications of marine biotechnology, and also in identifying factors that are impeding commercial exploitation of these products. This report includes a synthesis of the 2001 sessions addressing drug discovery and development, applications of genomics and proteomics to marine biotechnology, biomaterials and bioengineering, and public policy and essays contributed by the workshop speakers.
Author: Muhammad Taher Bakhtiar
Publisher: IIUM PRESS
ISBN: 9674911545
Category : Fiction
Languages : en
Pages : 66
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Book Description
This book is written to provide a brief overview concerning the latest drug discovery and its development based on the research studies that have been carried out until the present. The idea of preparing this book was inspired by the Holy Qur’an and the hadith, which guides us in all aspects of life, including disease management and treatment. This was supported by the traditional use of natural medicine by our ancestors. From the scientific point of view, we translate all those knowledge and information to be evidence-based modern medicines. We practised the common process of drug discovery development by identifying the potential molecule, followed by in vitro and in vivo experiments. The formulation is a crucial process to produce an efficient and effective drug delivery. Not to forget the future vision that “things would not give any meaning if it is not giving benefit to the people”. Commercialisation is one of the approaches to promote the product across the market and community. The book ends with the current issue of the COVID-19 global pandemic with regards to the treatment, natural medicine, and vaccination.
Author: Kan He
Publisher: Elsevier
ISBN: 0128171340
Category : Business & Economics
Languages : en
Pages : 446
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Book Description
Overcoming Obstacles in Drug Discovery and Development: Surmounting the Insurmountable uses real-world case studies to illustrate how critical thinking and problem-solving skills are applied and necessary in the discovery and development of drugs. The book shows how the development of critical thinking to overcome issues plays an essential role in scientific and professional expertise. As addressing critical, unexpected problems during development often requires scientists to utilize critical thinking and imaginative problem-solving skills, this book is an ideal training manual on how to overcome obstacles. It will be essential to young scientists who want to develop the skills to successfully face challenges, learn from their mistakes, and further develop critical thinking skills. It will also be beneficial to experienced researchers who can learn from case studies of successful and unsuccessful drug development Provides real-world case studies in drug discovery and the development of drugs Illustrates the use of critical thinking and problem-solving in approaching preclinical and clinical problems in drug discovery and development Analyzes examples of successes and failures in drug discovery and development that have not previously been reported
Author: Glenn F. King
Publisher: Royal Society of Chemistry
ISBN: 1782624376
Category : Science
Languages : en
Pages : 308
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Book Description
The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development. Case studies are used to illustrate methods and successes and highlight issues surrounding administration and other important lessons that have been learnt from the development of approved therapeutics based on venoms. The first text to focus on this fascinating area and bridging an important gap, this book provides the reader with essential and current knowledge on this fast-developing area. Venoms to Drugs will find wide readership with researchers working in academia and industry working in all medicinal and pharmaceutical areas.
Author: Divya Vohora
Publisher: Academic Press
ISBN: 0128020989
Category : Medical
Languages : en
Pages : 527
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Book Description
Pharmaceutical Medicine and Translational Clinical Research covers clinical testing of medicines and the translation of pharmaceutical drug research into new medicines, also focusing on the need to understand the safety profile of medicine and the benefit-risk balance. Pharmacoeconomics and the social impact of healthcare on patients and public health are also featured. It is written in a clear and straightforward manner to enable rapid review and assimilation of complex information and contains reader-friendly features.As a greater understanding of these aspects is critical for students in the areas of pharmaceutical medicine, clinical research, pharmacology and pharmacy, as well as professionals working in the pharmaceutical industry, this book is an ideal resource. - Includes detailed coverage of current trends and key topics in pharmaceutical medicine, including biosimilars, biobetters, super generics, and - Provides a comprehensive look at current and important aspects of the science and regulation of drug and biologics discovery
Author: Vishwanath Gaitonde
Publisher: BoD – Books on Demand
ISBN: 1789239753
Category : Medical
Languages : en
Pages : 166
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Book Description
The process of drug discovery and development is a complex multistage logistics project spanned over 10-15 years with an average budget exceeding 1 billion USD. Starting with target identification and synthesizing anywhere between 10k to 15k synthetic compounds to potentially obtain the final drug that reaches the market involves a complicated maze with multiple inter- and intra-operative fields. Topics described in this book emphasize the progresses in computational applications, pharmacokinetics advances, and molecular modeling developments. In addition the book also contains special topics describing target deorphaning in Mycobacterium tuberculosis, therapy treatment of some rare diseases, and developments in the pediatric drug discovery process.
Author: Pandey, Binay Kumar
Publisher: IGI Global
ISBN: 1668486202
Category : Computers
Languages : en
Pages : 594
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Book Description
Image processing integrates and extracts data from photos for a variety of uses. Applications for image processing are useful in many different disciplines. A few examples include remote sensing, space applications, industrial applications, medical imaging, and military applications. Imaging systems come in many different varieties, including those used for chemical, optical, thermal, medicinal, and molecular imaging. To extract the accurate picture values, scanning methods and statistical analysis must be used for image analysis. Thrust Technologies Effect on Image Processing provides insights into image processing and the technologies that can be used to enhance additional information within an image. The book is also a useful resource for researchers to grow their interest and understanding in the burgeoning fields of image processing. Covering key topics such as image augmentation, artificial intelligence, and cloud computing, this premier reference source is ideal for computer scientists, industry professionals, researchers, academicians, scholars, practitioners, instructors, and students.
Author: Mithun Rudrapal
Publisher: John Wiley & Sons
ISBN: 1394249179
Category : Science
Languages : en
Pages : 580
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Book Description
Comprehensive resource covering computational tools and techniques for the development of cost-effective drugs to combat diseases, with specific disease examples Computational Methods for Rational Drug Design covers the tools and techniques of drug design with applications to the discovery of small molecule-based therapeutics, detailing methodologies and practical applications and addressing the challenges of techniques like AI/ML and drug design for unknown receptor structures. Divided into 23 chapters, the contributors address various cutting-edge areas of therapeutic importance such as neurodegenerative disorders, cancer, multi-drug resistant bacterial infections, inflammatory diseases, and viral infections. Edited by a highly qualified academic with significant research contributions to the field, Computational Methods for Rational Drug Design explores topics including: Computer-assisted methods and tools for structure- and ligand-based drug design, virtual screening and lead discovery, and ADMET and physicochemical assessments In silico and pharmacophore modeling, fragment-based design, de novo drug design and scaffold hopping, network-based methods and drug discovery Rational design of natural products, peptides, enzyme inhibitors, drugs for neurodegenerative disorders, anti-inflammatory therapeutics, antibacterials for multi-drug resistant infections, and antiviral and anticancer therapeutics Protac and protide strategies in drug design, intrinsically disordered proteins (IDPs) in drug discovery and lung cancer treatment through ALK receptor-targeted drug metabolism and pharmacokinetics Helping readers seamlessly navigate the challenges of drug design, Computational Methods for Rational Drug Design is an essential reference for pharmaceutical and medicinal chemists, biochemists, pharmacologists, and phytochemists, along with molecular modeling and computational drug discovery professionals.
