Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test PDF Download
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Author: OECD
Publisher: OECD Publishing
ISBN: 9264224408
Category :
Languages : en
Pages : 16
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Book Description
The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters).
Author: OECD
Publisher: OECD Publishing
ISBN: 9264224408
Category :
Languages : en
Pages : 16
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Book Description
The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters).
Author: OECD
Publisher: OECD Publishing
ISBN: 926407130X
Category :
Languages : en
Pages : 8
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Book Description
The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters). Structural chromosome ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264264647
Category :
Languages : en
Pages : 22
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Book Description
This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264243178
Category :
Languages : en
Pages : 13
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Book Description
This test measures structural chromosomal aberrations (both chromosome- and chromatid-type) in dividing spermatogonial germ cells and is, therefore, expected to be predictive of induction of heritable mutations in these germ cells
Author: OECD
Publisher: OECD Publishing
ISBN: 9264224297
Category :
Languages : en
Pages : 21
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Book Description
The mammalian in vivo micronucleus test detects damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals.
Author: OECD
Publisher: OECD Publishing
ISBN: 926422422X
Category :
Languages : en
Pages : 20
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Book Description
This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264264787
Category :
Languages : en
Pages : 18
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Book Description
The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters).
Author: Organisation for Economic Co-operation and Development
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: OECD
Publisher: OECD Publishing
ISBN: 9264366067
Category :
Languages : en
Pages : 37
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Book Description
This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071261
Category :
Languages : en
Pages : 10
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Book Description
The purpose of the in vitro chromosome aberration test is to identify agents that cause structural chromosome aberrations in cultured mammalian somatic cells. Structural aberrations may be of two types: chromosome or chromatid. The in vitro ...
