Test No. 474: Mammalian Erythrocyte Micronucleus Test PDF Download
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Author: OECD
Publisher: OECD Publishing
ISBN: 9264224297
Category :
Languages : en
Pages : 21
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Book Description
The mammalian in vivo micronucleus test detects damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264224297
Category :
Languages : en
Pages : 21
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Book Description
The mammalian in vivo micronucleus test detects damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071288
Category :
Languages : en
Pages : 11
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Book Description
The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264264868
Category :
Languages : en
Pages : 30
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Book Description
The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264366067
Category :
Languages : en
Pages : 37
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Book Description
This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264264787
Category :
Languages : en
Pages : 18
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Book Description
The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters).
Author: OECD
Publisher: OECD Publishing
ISBN: 9264264760
Category :
Languages : en
Pages : 21
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Book Description
The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals, usually rodents (mice or rats).
Author: OECD
Publisher: OECD Publishing
ISBN: 9264264647
Category :
Languages : en
Pages : 22
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Book Description
This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264091017
Category :
Languages : en
Pages : 23
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Book Description
The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells. Micronuclei may originate from acentric chromosome fragments (i.e. lacking a centromere), or whole chromosomes that are ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264264809
Category :
Languages : en
Pages : 18
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Book Description
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl transferase...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071504
Category :
Languages : en
Pages : 6
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Book Description
The mouse heritable translocation test detects structural and numerical chromosome changes in mammalian germ cells as recovered in first generation progeny. The types of chromosome changes detected in this test system are reciprocal translocations ...
