OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 429: Skin Sensitisation Local Lymph Node Assay PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 429: Skin Sensitisation Local Lymph Node Assay PDF full book. Access full book title OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 429: Skin Sensitisation Local Lymph Node Assay by OECD. Download full books in PDF and EPUB format.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071105
Category :
Languages : en
Pages : 20
Get Book Here
Book Description
The basic principle underlying the Local Lymph Node Assay (LLNA) in mouse is that sensitizers induce a primary proliferation of lymphocytes in the auricular lymph nodes draining the site of chemical application. This proliferation is proportional to ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071105
Category :
Languages : en
Pages : 20
Get Book Here
Book Description
The basic principle underlying the Local Lymph Node Assay (LLNA) in mouse is that sensitizers induce a primary proliferation of lymphocytes in the auricular lymph nodes draining the site of chemical application. This proliferation is proportional to ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264090991
Category :
Languages : en
Pages : 34
Get Book Here
Book Description
The Local Lymph Node Assay: BrdU-ELISA (LLNA:BrdU-ELISA) is a non-radioactive modification to the LLNA method for identifying potential skin sensitizing test substances and measuring the proliferation of lymphocytes they induce in the auricular ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264229701
Category :
Languages : en
Pages : 63
Get Book Here
Book Description
This Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. It provides an in chemico procedure (Direct Peptide Reactivity Assay – DPRA) used for supporting the discrimination between skin sensitisers and non-sensitisers.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264229825
Category :
Languages : en
Pages : 67
Get Book Here
Book Description
This Test Guideline (TG) provides an in vitro procedure (the ARE-Nrf2 luciferase test method) used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264090975
Category :
Languages : en
Pages : 16
Get Book Here
Book Description
The Local Lymph Node Assay: DA (LLNA: DA) is a non-radioactive modification to the LLNA method for identifying potential skin sensitizing test substances and measuring the proliferation of lymphocytes they induce in the auricular lymph nodes. The ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264264353
Category :
Languages : en
Pages : 91
Get Book Here
Book Description
The present Key Event based Test Guideline (TG) addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). This TG is proposed to address the activation of dendritic cells, which is one Key Event on the Adverse Outcome Pathway (AOP) for Skin Sensitisation. It provides four in vitro test methods addressing the same Key Event on the AOP: (i) the human cell Line Activation Test or h-CLAT method, (ii) the U937 Cell Line Activation Test or U-SENS, (iii) the Interleukin-8 Reporter Gene Assay or IL-8 Luc assay and (iv) the Genomic Allergen Rapid Detection for assessment of skin sensitisers (GARDTMskin). All of them are used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS. The test methods described in this TG either quantify the change in the expression of cell surface marker(s) CD54 and CD86, the cytokine IL-8, or a series of genes (genomic biomarker signature) that are associated with the process of activation of monocytes and DC following exposure to sensitisers.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264903003
Category :
Languages : en
Pages : 53
Get Book Here
Book Description
A Defined Approach (DA) consists of a selection of information sources (e.g in silico predictions, in chemico, in vitro data) used in a specific combination, and resulting data are interpreted using a fixed data interpretation procedure (DIP) (e.g. a mathematical, rule-based model). DAs use methods in combination and are intended to overcome some limitations of the individual, stand-alone methods.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264279288
Category :
Languages : en
Pages : 317
Get Book Here
Book Description
With a view to assisting the evaluation of integrated approaches to testing and assessment (IATA) in regulatory decision-making within OECD Member Countries, this guidance document provides guidance on the reporting of defined approaches to testing and assessment in the area of skin ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264221441
Category :
Languages : en
Pages : 105
Get Book Here
Book Description
This document describes the state of knowledge of the adverse outcome pathway (AOP) for skin sensitisation initiated by covalent binding to proteins, assesses the weight-of-evidence supporting the AOP, identifies the key events, and identifies databases containing test results related to key events.
Author: Terje Svingen
Publisher: Frontiers Media SA
ISBN: 2832553389
Category : Medical
Languages : en
Pages : 125
Get Book Here
Book Description
The European Partnership on the Assessment of Risks from Chemicals (PARC) project was launched in 2022. The overarching aim of this partnership is to enhance our knowledge about chemical substances to better safeguard human health and the environment against harmful effects. The project will run for seven years under Horizon Europe. PARC is subdivided into several work packages (WPs). WP5 is focused on hazard assessment for human and environmental health and includes more than 80 partners across Europe. WP5 aims to fill data gaps for specified chemical substances of concern (e.g, bisphenol alternatives) and to develop or improve new approach methodologies (NAMs) for chemical hazard assessment. This is in order to progress towards a risk assessment paradigm relying less on animal toxicity data, both with respect to human health and environmental safety. As the PARC initiative will evolve over time with respect to both projects and activities, presenting early initiatives will foster an increased awareness of ongoing activities and potential incorporation of new activities going forward.
