Neuro-oncology Part 2, Gliomas and Other Primary Tumors of the Brain and Spinal Cord PDF Download
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Author: Ch. J. Vecht
Publisher: Elsevier
ISBN: 9780444812872
Category : Medical
Languages : en
Pages : 0
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Book Description
Neuro-Oncology is a three-part coverage of that subject over three volumes, comprehensive and multidisciplinary in its approach. This second part is devoted to the theme "Gliomas and Other Primary Tumors of the Brain and Spinal Cord". The first part of the volume focuses on the gliomas, representing the majority of malignant tumors of the brain. Proper classification of brain tumors is essential, and the adaptation of the last version of the World Health Organization's Recommendations on Classification and Grading of Primary Brain Tumors in 1993 are included in this volume and extensively discussed. On low-grade gliomas, the issue of wait-and-see or straightforward treatment, depending on symptomatology or localization in the infratentorial or supratentorial compartment, including optic pathway tumors, is reviewed in depth. For every tumor, epidemiology, neuropathology and clinical characteristics are an intrinsic part of each chapter in this volume. Although relatively rare, spinal cord tumors constitute a separate subject. Ample attention is given in this present work to primary tumors of the spinal cord and of the spinal column, with single sections devoted to solitary schwannomas, vascular tumors and malformations. The aim throughout is to present the reader with a comprehensive approach for each specific tumor, with attention being given to epidemiology, neuropathology, clinical and neuroimaging diagnosis and emphasizing treatment options.
Author: Ch. J. Vecht
Publisher: Elsevier
ISBN: 9780444812872
Category : Medical
Languages : en
Pages : 0
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Book Description
Neuro-Oncology is a three-part coverage of that subject over three volumes, comprehensive and multidisciplinary in its approach. This second part is devoted to the theme "Gliomas and Other Primary Tumors of the Brain and Spinal Cord". The first part of the volume focuses on the gliomas, representing the majority of malignant tumors of the brain. Proper classification of brain tumors is essential, and the adaptation of the last version of the World Health Organization's Recommendations on Classification and Grading of Primary Brain Tumors in 1993 are included in this volume and extensively discussed. On low-grade gliomas, the issue of wait-and-see or straightforward treatment, depending on symptomatology or localization in the infratentorial or supratentorial compartment, including optic pathway tumors, is reviewed in depth. For every tumor, epidemiology, neuropathology and clinical characteristics are an intrinsic part of each chapter in this volume. Although relatively rare, spinal cord tumors constitute a separate subject. Ample attention is given in this present work to primary tumors of the spinal cord and of the spinal column, with single sections devoted to solitary schwannomas, vascular tumors and malformations. The aim throughout is to present the reader with a comprehensive approach for each specific tumor, with attention being given to epidemiology, neuropathology, clinical and neuroimaging diagnosis and emphasizing treatment options.
Author: M.F. Chernov
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318060593
Category : Medical
Languages : en
Pages : 252
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Book Description
Treatment of patients with intracranial gliomas, especially high-grade neoplasms, usually requires postoperative adjuvant therapy. Significant progress in the understanding of tumor biology, technological advances in irradiation delivery, and development of novel antitumor drugs have led to an expansion of the therapeutic arsenal in neuro-oncology. This publication provides a unique review of the various options for adjuvant therapy. Special emphasis is on current evidence-based treatment standards and guidelines, and on perspectives of further improvement in long-term outcomes. Chapters review the histopathological and molecular features of gliomas and describe basic principles and clinical results of fractionated radiotherapy, stereotactic radiosurgery, brachytherapy, use of radiosensitizers, systemic chemotherapy and antiangiogenic therapy. Particular attention is paid to treatment of pediatric patients and to physical and psychological rehabilitation and supportive care at the end of life. This book and its accompanying volumes are mainly directed at neuro-oncologists, radiation oncologists, and other clinicians treating patients with brain tumors.
Author: Lee Roy Morgan
Publisher: BoD – Books on Demand
ISBN: 1789841577
Category : Medical
Languages : en
Pages : 278
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Book Description
Numerous new concepts and procedures are reviewed and discussed in this book and allude to the transport of drugs to the brain. New radiation concepts are also presented, plus management of toxicities associated with both treatment modalities. It is the goal of this book to provide information and data that will be useful for both researchers and practitioners to develop new approaches for the management of CNS malignancies.
Author: National Academies of Sciences Engineering and Medicine
Publisher:
ISBN: 9780309683494
Category :
Languages : en
Pages :
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Book Description
Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.
Author: Nima Rezaei
Publisher: Springer Nature
ISBN: 3031237056
Category : Medical
Languages : en
Pages : 754
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Book Description
This book aims to gather the current knowledge regarding different aspects of brain and spinal cord tumors in order to more efficiently help the patients. Brain tumors comprise about 5–9% of all human neoplasms; and the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. The more we know about the nature and characteristic of brain and spinal cord tumors, the more precise decision could be made for each patient, in order to reach the best outcome. While surgical resection, chemotherapy, and radiotherapy have been considered as the standards of care for benign and/or malignant CNS tumors since a long time ago, new therapeutic approaches such as immunotherapy have been recently proposed to be considered for treatment of CNS tumors, especially as in some cases, the tumors might be inoperable or the patient may not benefit from other treatment modalities after several recurrences. The second volume of the book focuses on clinical aspects of these tumors. Accordingly, the most important brain and spinal cord tumors are specifically discussed in each chapter based on a rational outlining for all chapter in this volume: Background and epidemiology, genetics, immunology and molecular biology, histopathology and morphology, imaging and radiologic features, clinical manifestations, therapeutic approaches, surgical intervention, chemotherapy and radiotherapy, new therapeutic modalities, follow-up, and prognosis. The chapters of this volume discuss the following pathologies of brain and spinal cord tumors: malignant glioma, benign glioma, meningiomas and other meningeal tumors, ependymomas, medulloblastomas, pineal tumors, choroid plexus and ventricular tumors, neuroectodermal tumors of CNS, neuroepithelial tumors of CNS, pituitary gland tumors, craniopharyngioma, schwannomas and nerve-sheet tumors, hemangioblastomas and other vascular originating tumors, brain and spinal tumors of embryonic origin, germ line cell tumors, malignant bone or cartilage-originating tumors of brain and spine, benign bone or cartilage-originating tumors of brain and spine, brain tumors affecting the orbit globe and orbit tumors affecting the brain, CNS lymphomas, metastatic lesions of the brain and spine, malignant spinal tumors, benign spinal tumors, brain and/or spinal cord tumors accompanied with other diseases or syndromes, psychological and psychiatric aspects of brain and spinal cord tumors, a brief explanation on surgical approaches for treatment of different brain tumors. This volume of book is useful for physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists, and neuroradiologists.
Author: M.A. Hayat
Publisher: Springer Science & Business Media
ISBN: 9400706189
Category : Medical
Languages : en
Pages : 449
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Book Description
Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are explained in detail. Both low-grade and high-grade gliomas are discussed. Conventional as well as fluorescent-guided resection techniques for high-grade, recurrent malignant gliomas are detailed. Impact of resection extent on outcomes in patients with high-grade gliomas is clarified. The advantage of the use of intraoperative low-field MRI in glioma surgery is explained.
Author: M.A. Hayat
Publisher: Springer Science & Business Media
ISBN: 9400717067
Category : Medical
Languages : en
Pages : 381
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Book Description
This volume mainly contains information on the diagnosis, therapy, and prognosis of brain tumors. Insights on the understanding of molecular pathways involved in tumor biology are explained, which should lead to the development of effective drugs. Information on pathways (e.g., hedgehog) facilitates targeted therapies in cancer. Tumor models are also presented, which utilize expression data, pathway sensitivity, and genetic abnormalities, representing targets in cancer. For example, rat model of malignant brain tumors using implantation of doxorubicin with drug eluting beads for delivery is explained. The future of pathway-driven therapies for tumors is summarized. The importance of personalizing cancer care is emphasized. The need for supportive measures for survivors of brain cancer is pointed out, so is the quality of life monitoring. The need of rehabilitation therapy for patients with primary and metastatic brain tumors is also emphasized. Role of MicroRNA in distinguishing primary tumors from metastatic primary tumors is discussed. Advantages and limitations of chemotherapy (e.g., temozolomide and doxorubicin) are discussed. The complexity of tumor to tumor transfer is explained; examples discussed are: brain metastases from breast cancer and brain metastases fro non-small cell lung carcinoma. Identification and characterization of biomarkers, including those for metastatic brain tumors, are presented. Genomic analysis for identifying clinically relevant subtypes of glioblastoma is included. A large number of imaging modalities are detailed to study progression and invasion of gliomas
Author: Alecsandru Ioan Baba
Publisher:
ISBN: 9789732714577
Category : Electronic books
Languages : en
Pages : 787
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Book Description
Author: David Glyndor Treharne Thomas
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 328
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Book Description
Author: Marcos Vinicius Calfat Maldaun
Publisher: Frontiers Media SA
ISBN: 2889638529
Category :
Languages : en
Pages : 111
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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
