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Author: John Moffett
Publisher: Springer Science & Business Media
ISBN: 0387301720
Category : Medical
Languages : en
Pages : 379
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Book Description
N-acetylaspartate (NAA), the acetylated form of the amino acid aspartate, is one of the most highly concentrated chemicals in the brains of humans, yet its function remains elusive. NAA is used in nonsurgical analyses of nerve cell dysfunction, and it is implicated in a disorder known as Canavan’s disease. This book reviews research from around the world in the study of NAA, and the roles it plays in neuronal development and functioning.
Author: John Moffett
Publisher: Springer Science & Business Media
ISBN: 0387301720
Category : Medical
Languages : en
Pages : 379
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Book Description
N-acetylaspartate (NAA), the acetylated form of the amino acid aspartate, is one of the most highly concentrated chemicals in the brains of humans, yet its function remains elusive. NAA is used in nonsurgical analyses of nerve cell dysfunction, and it is implicated in a disorder known as Canavan’s disease. This book reviews research from around the world in the study of NAA, and the roles it plays in neuronal development and functioning.
Author: In-Young Choi
Publisher: Springer Science & Business Media
ISBN: 1461417880
Category : Medical
Languages : en
Pages : 1168
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Book Description
From the preface: “Neural Metabolism In Vivo aims to provide a comprehensive overview of neurobiology by presenting the basic principles of up-to-date and cutting-edge technology, as well as their application in assessing the functional, morphological and metabolic aspects of the brain. Investigation of neural activity of the living brain via neurovascular coupling using multimodal imaging techniques extended our understanding of fundamental neurophysiological mechanisms, regulation of cerebral blood flow in connection to neural activity and the interplay between neurons, astrocytes and blood vessels. Constant delivery of glucose and oxygen for energy metabolism is vital for brain function, and the physiological basis of neural activity can be assessed through measurements of cerebral blood flow and consumption of glucose and oxygen.... This book presents the complex physiological and neurochemical processes of neural metabolism and function in response to various physiological conditions and pharmacological stimulations. Neurochemical detection technologies and quantitative aspects of monitoring cerebral energy substrates and other metabolites in the living brain are described under the “Cerebral metabolism of antioxidants, osmolytes and others in vivo” section. Altogether, the advent of new in vivo tools has transformed neuroscience and neurobiology research, and demands interdisciplinary approaches as each technology could only approximate a very small fraction of the true complexity of the underlying biological processes. However, translational values of the emerging in vivo methods to the application of preclinical to clinical studies cannot be emphasized enough. Thus, it is our hope that advances in our understanding of biochemical, molecular, functional and physiological processes of the brain could eventually help people with neurological problems, which are still dominated by the unknowns.” -- In-Young Choi and Rolf Gruetter
Author: Gerrit L. Verschuur
Publisher:
ISBN: 9783540962809
Category : Radio astronomy
Languages : en
Pages : 276
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Book Description
Author: Juan M. Pascual
Publisher: Cambridge University Press
ISBN: 1107042054
Category : Medical
Languages : en
Pages : 507
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Book Description
A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.
Author: Michael G. Kaplitt
Publisher: Elsevier
ISBN: 0080454372
Category : Science
Languages : en
Pages : 372
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Book Description
Few areas of biomedical research provide greater opportunities for radically new therapies for devastating diseases that have evaded treatment so far than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy of the Central Nervous System: From Bench to Bedside represents the first definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped create this field and are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects of interest to anyone exploring or using gene therapy for neurobiological applications in research and clinical praxis.* Presents gene transfer technologies with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells* Discusses preclinical areas that are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis* Includes "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use
Author: Ruben Kuzniecky
Publisher: Academic Press
ISBN: 0080535712
Category : Medical
Languages : en
Pages : 461
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Book Description
Remarkable advances in imaging have increased the importance of MRI for diagnostic, treatment and management of epilepsy. Neuroimaging of patients with epilepsy no longer simply deals with the technology and interpretation of images but also with issues of brain metabolism, energetics, cognition and brain dysfunction. The first edition of Magnetic Resonance in Epilepsy came into clinical practice in 1995 with a revolutionary idea; that is, MR is as important as EEG in the clinical management of patients with epilepsy. The second edition of Magnetic Resonance in Epilepsy, the only comprehensive text in the field of epilepsy neuroimaging, reviews fundamental concepts and new advances in MR technology, computerized analysis, MR spectroscopy, DWI and other neuroimaging techniques such as PET, SPECT and MEG application to the study of patients with epileptic disorders.*Provides a crucial update of recent advances in imaging techniques*Timely publication as subject of neuroimaging is a very "hot" area in both clinical epilepsy and basic neuroscience research*Editors are well-respected in this field
Author: Charlotte Stagg
Publisher: Academic Press
ISBN: 0124016979
Category : Medical
Languages : en
Pages : 376
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Book Description
Magnetic Resonance Spectroscopy: Tools for Neuroscience Research and Emerging Clinical Applications is the first comprehensive book for non-physicists that addresses the emerging and exciting technique of magnetic resonance spectroscopy. Divided into three sections, this book provides coverage of the key areas of concern for researchers. The first, on how MRS is acquired, provides a comprehensive overview of the techniques, analysis, and pitfalls encountered in MRS; the second, on what can be seen by MRS, provides essential background physiology and biochemistry on the major metabolites studied; the final sections, on why MRS is used, constitutes a detailed guide to the major clinical and scientific uses of MRS, the current state of teh art, and recent innovations. Magnetic Resonance Spectroscopy will become the essential guide for people new to the technique and give those more familiar with MRS a new perspective. - Chapters written by world-leading experts in the field - Fully illustrated - Covers both proton and non-proton MRS - Includes the background to novel MRS imaging approaches
Author: Omar H. Saab
Publisher:
ISBN:
Category : Amino acids
Languages : en
Pages : 538
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Book Description
Author: Semyon M. Slobounov
Publisher: Springer Science & Business Media
ISBN: 0387325654
Category : Medical
Languages : en
Pages : 482
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Book Description
In summarizing current insights and controversies over concussions in athletics, this book makes the vital point that symptom resolution does not necessarily mean injury resolution. Research shows that dysfunctional pathways continue for extended periods even after a minor concussion. Until the consequences of short-term perturbations and long-term residual brain dysfunctions are better understood, concussions must be treated with respect and given a higher priority for continued research activity.
Author: Else Rubaek Danielsen
Publisher: CRC Press
ISBN: 1482270102
Category : Medical
Languages : en
Pages : 344
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Book Description
Demonstrates how MRS offers a useful tool for the noninvasive biochemical analysis of the brain. The book covers over 70 clinical cases and more than 100 spectra that enhance skills at interpreting MRS, including minimizing errors, highlighting artifacts, and expanding the clinical usefulness of this diagnostic modality.
