Fast Facts: Myeloproliferative Neoplasms

Fast Facts: Myeloproliferative Neoplasms PDF Author: R.A. Mesa
Publisher: Karger Medical and Scientific Publishers
ISBN: 1910797804
Category : Medical
Languages : en
Pages : 117

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Book Description
Presentation of the myeloproliferative neoplasms (MPNs) varies widely, and correct diagnosis and management can be challenging, and is becoming more complex as understanding of the underlying molecular basis for these disorders emerges. Appropriate management is increasingly informed by accurate risk stratification founded on understanding of cytogenetic and molecular markers, as well as the clinical presentation. 'Fast Facts: myeloproliferative neoplasms' focuses on the three most common chronic MPNs: • Essential thrombocythemia (ET) – characterized by increased platelet count • Polycythemia vera (PV) – characterized by excessive production of red blood cells • Primary myelofibrosis – a more severe and heterogenous disorder that may overlap with ET and PV but is commonly associated with anemia. Written by two leading experts in the field, Fast Facts: myeloproliferative neoplasms provides concise, up-to-date and practical guidance on the accurate diagnosis, risk stratification and management of these MPNs. It also provides key insights into our growing understanding of the underlying molecular and genetic basis of these disorders, and how this is informing risk stratification and management strategies. This concise handbook will be invaluable to clinicians, medical students, nurses, pharmacists and scientists in understanding and overcoming the everyday and rarer challenges associated with MPN.

Fast Facts: Myeloproliferative Neoplasms

Fast Facts: Myeloproliferative Neoplasms PDF Author: R.A. Mesa
Publisher: Karger Medical and Scientific Publishers
ISBN: 1910797804
Category : Medical
Languages : en
Pages : 117

Get Book Here

Book Description
Presentation of the myeloproliferative neoplasms (MPNs) varies widely, and correct diagnosis and management can be challenging, and is becoming more complex as understanding of the underlying molecular basis for these disorders emerges. Appropriate management is increasingly informed by accurate risk stratification founded on understanding of cytogenetic and molecular markers, as well as the clinical presentation. 'Fast Facts: myeloproliferative neoplasms' focuses on the three most common chronic MPNs: • Essential thrombocythemia (ET) – characterized by increased platelet count • Polycythemia vera (PV) – characterized by excessive production of red blood cells • Primary myelofibrosis – a more severe and heterogenous disorder that may overlap with ET and PV but is commonly associated with anemia. Written by two leading experts in the field, Fast Facts: myeloproliferative neoplasms provides concise, up-to-date and practical guidance on the accurate diagnosis, risk stratification and management of these MPNs. It also provides key insights into our growing understanding of the underlying molecular and genetic basis of these disorders, and how this is informing risk stratification and management strategies. This concise handbook will be invaluable to clinicians, medical students, nurses, pharmacists and scientists in understanding and overcoming the everyday and rarer challenges associated with MPN.

Myeloproliferative Neoplasms

Myeloproliferative Neoplasms PDF Author: Tiziano Barbui
Publisher: Springer Science & Business Media
ISBN: 3642249884
Category : Medical
Languages : en
Pages : 235

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Book Description
This book focuses on three of the main categories of myeloproliferative neoplasm: polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Relevant laboratory and clinical advances are comprehensively covered, and great emphasis is placed on the practical issues that challenge physicians in their daily practice. The main topics considered thus include contemporary diagnostic approaches, the value and limitations of mutation screening for diagnostic and prognostic purposes, risk stratification in terms of both survival and other disease complications such as leukemic transformation and thrombosis, and modern therapeutic strategies, including conventional drugs, allogeneic stem cell transplantation, and experimental drugs still under study. The reader will find Critical Concepts and Management Recommendations in Myeloproliferative Neoplasms to be an invaluable and up-to-date source of information from leading authorities in the field.

Oxford Specialist Handbook: Myeloproliferative Neoplasms

Oxford Specialist Handbook: Myeloproliferative Neoplasms PDF Author: Tariq I. Mughal
Publisher:
ISBN: 0198744218
Category : Medical
Languages : en
Pages : 361

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Book Description
Our understanding of myeloproliferative neoplasms (MPN) disorders has grown considerably over the past four decades. iMyeloproliferative Neoplasms/i offers a detailed evidence-based guide to MPNs in an easily accessible format, structure to facilitate learning specialist information presenting core information in 'bite size' chunks.

Chronic Myeloproliferative Disorders

Chronic Myeloproliferative Disorders PDF Author: Tariq Mughal
Publisher: CRC Press
ISBN: 9780415415989
Category : Medical
Languages : en
Pages : 0

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Book Description
With the new classification of chronic myeloproliferative disorders, and the rise of interest in molecularly targeted therapies, this timely text brings together international experts on the topic to discuss the current technologies and their implications for the treatment of patients. This title comprehensively covers chronic myeloid leukemia and Ph-negative chronic myeloproliferative disorders and is an essential resource for all practitioners in Hematologic Oncology.

Bone Marrow Biopsy Pathology

Bone Marrow Biopsy Pathology PDF Author: Christine Beham-Schmid
Publisher: Springer Nature
ISBN: 3662603098
Category : Medical
Languages : en
Pages : 544

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Book Description
This comprehensive, superbly illustrated reference is designed to provide practical diagnostic assistance for hematopathologists when dealing with common and uncommon lesions in bone marrow trephine biopsies (BMTBs). At the heart of the book is a systematic analysis of neoplastic hematological and non-hematological disease entities, with concise identification of the key features of myeloproliferative neoplasms, myelodysplastic syndromes, acute and chronic leukemias, eosinophilia-associated myeloid/lymphoid neoplasms, lymphoproliferative disorders, and selected non-hematopoietic malignancies. Relevant examples of BMTBs are presented, with microscopic description, high-quality photomicrographs, and clinical data. The book also explains how to assess hematopoietic and stromal components of normal BMTBs, identifies the heterogeneous patterns that may be observed in healthy individuals, and analyzes reactive conditions, with particular attention to diagnostic problems and pitfalls.

Atlas of Differential Diagnosis in Neoplastic Hematopathology

Atlas of Differential Diagnosis in Neoplastic Hematopathology PDF Author: Wojciech Gorczyca
Publisher: CRC Press
ISBN: 1439806489
Category : Medical
Languages : en
Pages : 696

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Book Description
This Atlas is an essential guide to both the diagnosis and differential diagnosis of neoplastic hematopathologies, based on specific parameters. It will be an invaluable reference for all practicing hematologists, oncologists and pathologists.Atlas of Differential Diagnosis in Neoplastic Hematopathology, Second Edition discusses:basic clinical data

The EBMT Handbook

The EBMT Handbook PDF Author: Nicolaus Kröger
Publisher:
ISBN: 9781013273667
Category : Medical
Languages : en
Pages : 688

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Book Description
This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Cytogenetic Abnormalities

Cytogenetic Abnormalities PDF Author: Susan Mahler Zneimer
Publisher: John Wiley & Sons
ISBN: 1118412567
Category : Science
Languages : en
Pages : 672

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Book Description
Cytogenetics is the study of the structure and function of chromosomes in relation to phenotypic expression.Chromosomal abnormalities underlie the development of a wide variety of diseases and disorders ranging from Down syndrome to cancer, and are of widespread interest in both basic and clinical research. Cytogenetic Abnormalities: Chromosomal, FISH, and Microarray-Based Clinical Reporting is a practical guide that describes cytogenetic abnormalities, their clinical implications and how best to report and communicate laboratory findings in research and clinical settings. The text first examines chromosomal, FISH, and microarray-based analyses in constitutional disorders. Using these same methodologies, the book's focus shifts to acquired abnormalities in cancers. Both sections provide illustrative examples of cytogenetic abnormalities and how to communicate these findings in standardized laboratory reports. Providing both a wealth of cytogenetic information, as well as practical guidance on how best to communicate findings to fellow research and medical professionals, Cytogenetic Abnormalities will be an essential resource for cytogeneticists, laboratory personnel, clinicians, research scientists, and students in the field. A guide to interpreting and reporting cytogenetic laboratory results involved in constitutional disorders and cancers Guides the reader on implementing the International System for Human Cytogenetic Nomenclature in written reports Provides information to allow scientists and medical professionals to fully understand and communicate cytogenetic abnormalities Describes a wide array of cytogenetic abnormalities observed in the laboratory Divided into user-friendly sections devoted to methodologies and implications of specific diseases

Managing Myeloproliferative Neoplasms

Managing Myeloproliferative Neoplasms PDF Author: Ruben A. Mesa
Publisher: Cambridge University Press
ISBN: 1316033775
Category : Medical
Languages : en
Pages : 207

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Book Description
This is a concise, practical, case-based book documenting examples and scenarios that will help you manage challenging clinical issues for patients with myeloproliferative neoplasms. The editors and authors have strived to distil the very latest information in this rapidly advancing field in a way that will help you to update your practice and manage your patients. The key focuses are: diagnosis, both standard and challenging; both day-to-day management as well as special situations such as surgery, thrombotic events and pregnancy; and finally, managing evolving situations with MPN such as progression to acute myeloid leukemia. This book is an outstanding resource that includes a discussion of both classical myeloproliferative neoplasms, such as essential thrombocythemia, polycythemia vera and myelofibrosis, and also less common disorders such as systemic mast cell disease, hypereosinophilia, MPN/MBS overlap syndromes and atypical CML, amongst others. This book is a practical reference for practitioners, hematologists, medical oncologists and trainees.

Biology and Treatment of Leukemia and Bone Marrow Neoplasms

Biology and Treatment of Leukemia and Bone Marrow Neoplasms PDF Author: Vinod Pullarkat
Publisher: Springer Nature
ISBN: 3030783111
Category : Medical
Languages : en
Pages : 200

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Book Description
This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students.