Molecular Mechanisms of Ventilator-induced Lung Injury [microform]: Biotrauma PDF Download
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![Molecular Mechanisms of Ventilator-induced Lung Injury [microform]: Biotrauma PDF](https://books.google.com/books/content/images/frontcover/YTJ1tgAACAAJ?fife=w150-h200)
Author: Lorraine N. Tremblay
Publisher: National Library of Canada = Bibliothèque nationale du Canada
ISBN: 9780612415218
Category :
Languages : en
Pages : 392
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Book Description
![Molecular Mechanisms of Ventilator-induced Lung Injury [microform]: Biotrauma PDF](https://books.google.com/books/content/images/frontcover/YTJ1tgAACAAJ?fife=w80-h100)
Author: Lorraine N. Tremblay
Publisher: National Library of Canada = Bibliothèque nationale du Canada
ISBN: 9780612415218
Category :
Languages : en
Pages : 392
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Book Description
Author: Didier Dreyfuss
Publisher: CRC Press
ISBN: 1420019260
Category : Medical
Languages : en
Pages : 776
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Book Description
This reference surveys current best practices in the prevention and management of ventilator-induced lung injury (VILI) and spans the many pathways and mechanisms of VILI including cell injury and repair, the modulation of alveolar-capillary barrier properties, and lung and systemic inflammatory consequences of injurous mechanical ventilation. Cons
Author: Joseph Ames Herbert
Publisher:
ISBN:
Category :
Languages : en
Pages : 126
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Book Description
Abstract Background The majority of patients requiring mechanical ventilation are over the age of 65 and advanced age is known to increase the severity of ventilator-induced lung injury (VILI) and mortality. However, the mechanisms which predispose aging ventilator patients to increased mortality rates are not fully understood. Pulmonary edema is a hallmark of VILI and the severity of edema increases with age. Ventilation with conservative fluid management decreases mortality rates in acute respiratory distress (ARDS) patients, but has not been investigated in VILI. We hypothesized that age-associated increases in pulmonary edema promote age-related increases in ventilator-associated mortality. Endoplasmic reticulum (ER) stress can disrupt cellular functions and plays a key role in many disease states. The severity of ER stress also increases with age. We hypothesized that age-associated increases in ER stress also increase in the severity of VILI. Finally, serum Vitamin C (VitC) levels also decrease with age. VitC treatments have been shown to decrease mortality rates in murine models of ARDS by and attenuate pulmonary edema. We hypothesize that VitC treatments will attenuate ventilator induced pulmonary edema in our aged murine subjects. Methods Mechanical Ventilation: Young and old mice were mechanically ventilated with either high tidal volume (HVT) or low tidal volume (LVT) for with either liberal or conservative fluid support. One group received VitC treatment prior to ventilation. Cell Stretch: Alveolar epithelial cells (ATIIs) from young and old mice were harvested, cultured, and mechanically stretched. Treatment groups received ER stress inhibitor 4-PBA. Results Both advanced age and HVT ventilation significantly increased inflammation, injury, and decreased survival rates. Conservative fluid support significantly diminished pulmonary edema decreased mortality rates. VitC treatments significantly decreased pulmonary edema and improved pulmonary mechanics. Mechanical stretch promoted ER Stress and upregulated proinflammatory gene expression and secretion in aged ATIIs. ER stress inhibition attenuated all of these effects. Conclusion Conservative fluid management alone attenuated age-associated increases in ventilator-associated mortality. VitC treatments decreased pulmonary edema and partially restore pulmonary mechanics in old mice ventilated with HVT. ER stress inhibition decreased stretch induced proinflammatory gene expression and protein secretion in aged mechanically stretched ATII cells.
Author: Fuest, Sven
Publisher: Lehmanns Media
ISBN: 3865416160
Category : Artificial respiration
Languages : de
Pages : 75
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Book Description
Beschreibung: This thesis evaluates molecular mechanisms involved in acute respiratory distress syndrome and ventilator-induced lung injury. Open-lung ventilation strategies are known to be lung protective. Different molecular biological and immunohistochemical research methods provided discoveries in the lung protective mechanisms induced by open-lung ventilation strategies. The thesis illustrates these scientific findings imbedded in detailed description of the used research methods and basic as well as up-to-date knowledge of acute respiratory distress syndrome, ventilator-induced lung injury, and cell death mechanisms. Coloured figures facilitate the understanding of the findings.
Author: Ashfaq Hasan
Publisher: Springer Science & Business Media
ISBN: 1848828691
Category : Medical
Languages : en
Pages : 554
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Book Description
Simplify, simplify! Henry David Thoreau For writers of technical books, there can be no better piece of advice. Around the time of writing the first edition – about a decade ago – there were very few monographs on this s- ject: today, there are possibly no less than 20. Based on critical inputs, this edition stands thoroughly revamped. New chapters on ventilator waveforms, airway humidification, and aerosol therapy in the ICU now find a place. Novel software-based modes of ventilation have been included. Ventilator-associated pneumonia has been se- rated into a new chapter. Many new diagrams and algorithms have been added. As in the previous edition, considerable energy has been spent in presenting the material in a reader-friendly, conv- sational style. And as before, the book remains firmly rooted in physiology. My thanks are due to Madhu Reddy, Director of Universities Press – formerly a professional associate and now a friend, P. Sudhir, my tireless Pulmonary Function Lab technician who found the time to type the bits and pieces of this manuscript in between patients, A. Sobha for superbly organizing my time, Grant Weston and Cate Rogers at Springer, London, Balasaraswathi Jayakumar at Spi, India for her tremendous support, and to Dr. C. Eshwar Prasad, who, for his words of advice, I should have thanked years ago. vii viii Preface to the Second Edition Above all, I thank my wife and daughters, for understanding.
Author: Jean-Louis Vincent
Publisher: Springer Science & Business Media
ISBN: 3319037463
Category : Medical
Languages : en
Pages : 755
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Book Description
The Yearbook compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.
Author: D. Kirk Hamilton
Publisher: Routledge
ISBN: 1136441190
Category : Architecture
Languages : en
Pages : 314
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Book Description
It is now widely recognized that the physical environment has an impact on the physiology, psychology, and sociology of those who experience it. When designing a critical care unit, the demands on the architect or designer working together with the interdisciplinary team of clinicians are highly specialized. Good design can have a hugely positive impact in terms of the recovery of patients and their hospital experience as a whole. Good design can also contribute to productivity and quality of the work experience for the staff. 'Design for Critical Care' presents a thorough and insightful guide to the very best practice in intensive care design, focusing on design that has been successful and benefi cial to both hospital staff and hospital patients. By making the connection between research evidence and design practice, Hamilton and Shepley present an holistic approach that outlines the future for successful design for critical care settings.
Author: Henry G. W. Paw
Publisher: Cambridge University Press
ISBN: 9781841101422
Category : Medical
Languages : en
Pages : 174
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Book Description
The invention of positive-pressure ventilators and the growth of ICUs have improved our ability to keep critically ill and mechanically ventilated patients alive longer, and as a result, prolonged ventilatory assistance has become more and more common. In recent years, there has been a shift away from translaryngeal intubation in favour of tracheostomy for better long-term airway access in patients who require prolonged ventilatory support. This well illustrated, practical text provides the newcomer to percutaneous tracheostomy with a perfect introduction to this increasingly widely used technique. It provides an overview of the history of the technique, the basic anatomy of relevance to the user, and the indications and contraindications for its use, and goes on to describe the key advantages of the technique over other methods, which kits are currently available for use (and their relative merits), equipment and aids for percutaneous tracheostomy, and the anaesthetic techniques involved.
Author: Jean-Louis Vincent
Publisher: Springer
ISBN: 3319137611
Category : Medical
Languages : en
Pages : 582
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Book Description
The Yearbook compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.
Author: Jean-Louis Vincent
Publisher: Springer
ISBN: 9783319273488
Category : Medical
Languages : en
Pages : 0
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Book Description
The Annual Update compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.
