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Author: D.G. Stavenga
Publisher: Elsevier
ISBN: 0080536778
Category : Science
Languages : en
Pages : 597
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Book Description
Molecular mechanisms in visual transduction is presently one of the most intensely studied areas in the field of signal transduction research in biological cells. Because the sense of vision plays a primary role in animal biology, and thus has been subject to long evolutionary development, the molecular and cellular mechanisms underlying vision have a high degree of sensitivity and versatility. The aims of visual transduction research are firstto determine which molecules participate, and then to understand how they act in concert to produce the exquisite electrical responses of the photoreceptor cells.Since the 1940s [1] we have known that rod vision begins with the capture of a quantum of energy, a photon, by a visual pigment molecule, rhodopsin. As the function of photon absorption is to convert the visual pigment molecule into a G-protein activating state, the structural details of the visual pigments must beexplained from the perspective of their role in activating their specific G-proteins. Thus, Chapters 1-3 of this Handbook extensively cover the physico-chemical molecular characteristics of the vertebrate rhodopsins. Following photoconversion and G-protein activation, the phototransduction cascade leads to modifications of the population of closed and open ion channels in the photoreceptor plasma membrane, and thereby to the electrical response. The nature of the channels of vertebrate photoreceptors is examined in Chapter 4, and Chapter 5 integrates the present body of knowledge of the activation steps in the cascade into a quantitative framework. Once the phototransduction cascade is activated, it must be subsequently silenced. The various molecular mechanisms participating in inactivation aretreated in Chapters 1-4 and especially Chapter 5. Molecular biology is now an indispensable tool in signal transduction studies. Numerous vertebrate (Chapter 6) and invertebrate (Chapter 7) visual pigments have been characterized and cloned. The genetics and evolutionary aspects of this great subfamily of G-protein activating receptors are intriguing as they present a natural probe for the intimate relationship between structure and function of the visual pigments. Understanding the spectral characteristics from the molecular composition can be expected to
Author: D.G. Stavenga
Publisher: Elsevier
ISBN: 0080536778
Category : Science
Languages : en
Pages : 597
Get Book Here
Book Description
Molecular mechanisms in visual transduction is presently one of the most intensely studied areas in the field of signal transduction research in biological cells. Because the sense of vision plays a primary role in animal biology, and thus has been subject to long evolutionary development, the molecular and cellular mechanisms underlying vision have a high degree of sensitivity and versatility. The aims of visual transduction research are firstto determine which molecules participate, and then to understand how they act in concert to produce the exquisite electrical responses of the photoreceptor cells.Since the 1940s [1] we have known that rod vision begins with the capture of a quantum of energy, a photon, by a visual pigment molecule, rhodopsin. As the function of photon absorption is to convert the visual pigment molecule into a G-protein activating state, the structural details of the visual pigments must beexplained from the perspective of their role in activating their specific G-proteins. Thus, Chapters 1-3 of this Handbook extensively cover the physico-chemical molecular characteristics of the vertebrate rhodopsins. Following photoconversion and G-protein activation, the phototransduction cascade leads to modifications of the population of closed and open ion channels in the photoreceptor plasma membrane, and thereby to the electrical response. The nature of the channels of vertebrate photoreceptors is examined in Chapter 4, and Chapter 5 integrates the present body of knowledge of the activation steps in the cascade into a quantitative framework. Once the phototransduction cascade is activated, it must be subsequently silenced. The various molecular mechanisms participating in inactivation aretreated in Chapters 1-4 and especially Chapter 5. Molecular biology is now an indispensable tool in signal transduction studies. Numerous vertebrate (Chapter 6) and invertebrate (Chapter 7) visual pigments have been characterized and cloned. The genetics and evolutionary aspects of this great subfamily of G-protein activating receptors are intriguing as they present a natural probe for the intimate relationship between structure and function of the visual pigments. Understanding the spectral characteristics from the molecular composition can be expected to
Author: Joyce Tombran-Tink
Publisher: Springer Science & Business Media
ISBN: 1597453749
Category : Medical
Languages : en
Pages : 504
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Book Description
This book reveals not only how the eye evolved into an organ of vision, but also describes how molecular mechanisms of key molecules operate in the phototransduction cascade. In this groundbreaking text, experts also explain mechanisms for sensing radiation outside of the visible wavelengths. Comprehensive and penetrating, the book brings together the mechanisms of the visual transduction cascade and is an invaluable text for everyone conducting research in the visual system.
Author: Ikuo Takeuchi
Publisher: John Wiley & Sons
ISBN: 0470515708
Category : Medical
Languages : en
Pages : 316
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Book Description
Brings together key new results of interdisciplinary collaborations among various research fields on rhodopsin including the photoreceptive mechanism of rhodopsins, the molecular mechanism of the visual transduction process, visual processes in the retina and other transduction processes in the retina and brain. The structures of the rhodopsin molecule are studied in the fields of protein chemistry, molecular biology, organic chemistry and structural biology; the ultra fast reactions of the retinal protein are studied in physics, biophysics, physical chemistry, organic chemistry and photobiology; the phototransduction in retinal proteins and visual cells are studied in biophysics, biochemistry, biophysical chemistry and photobiology; and the localization in the tissues is studied in anatomy and histochemistry. The diversity of visual systems in various animals is studied in zoology and comparative biochemistry.
Author: Helga Kolb
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Hugo J. Bellen
Publisher: Oxford University Press, USA
ISBN:
Category : Medical
Languages : en
Pages : 466
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Book Description
This book provides the reader with background information on neurotransmitter release. Emphasis is placed on the rationale by which proteins are assigned specific functions rather than just providing facts about function.
Author: Steven J. Fliesler
Publisher: CRC Press
ISBN: 1420007165
Category : Medical
Languages : en
Pages : 410
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Book Description
In the twenty-first century, we are just beginning to understand more clearly the enormous diversity and complexity of signaling processes in the retina. Integrating advances in the biochemistry, cell biology, physiology, and physics of phototransduction, Signal Transduction in the Retina presents the methodologies and experimental approache
Author: Henning Stieve
Publisher: Springer Science & Business Media
ISBN: 3642704441
Category : Medical
Languages : en
Pages : 510
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Book Description
very important, especially the comparison of vertebrate and invertebrate transduction mechanisms. The workshop was very successful and the outcome of the discussions proved it worth the effort. To no small extent has that success been made possible by Dr. Silke Bernhard who with a combination of authority and charm together with her extremely efficient and dedicated staff organized this workshop, providing the conditions and framework for a scientific debate of outstanding quality in a friendly and pleasant atmosphere. The great majority of participants were also very committed to making this workshop successful. Besides the reports of the four discussion groups, this publication contains the background papers which were revised by the authors partly as a result of suggestions of some participants. I hope this book will give a fair overview of the state of our knowledge of research in visual transduction. It was a pleasure to edit, especially because of the friendly and very efficient commitment of K. Geue, J. Lupp, and A. Eckert and the cooperativeness of most of the contributors. Particularly I would like to acknowledge gratefully the extensive efforts and patience of the four rapporteurs, M.L. Applebury, W.H. Miller, W.G. Owen, and E.N. Pugh, Jr., in compiling, writing, and revising the group reports. REFERENCES (1) Altman, J. 1985. Sensory transduction, new visions in photoreception. Nature 313: 264-265. (2) Hagins, W.A. 1972. The visual process: Excitatory mechanisms in the primary receptor cells. Ann. Rev. Biophys. Bioeng. 1: 131-158.
Author: William Hughes Miller
Publisher:
ISBN: 9780121533151
Category : Science
Languages : en
Pages : 452
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Book Description
Author: Carlo Musio
Publisher: World Scientific
ISBN: 9812799974
Category : Medical
Languages : en
Pages : 510
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Book Description
The light sense is conceivably the key sense in both the animal and the plant kingdom. Vision research, undoubtedly a fast-growing field, is providing impressive results OCo thanks to modern theoretical and methodological advances. The approach of biophysics and neuroscience seems to be of great benefit and, for this reason, the present book gives an outline of recent acquisitions and updated advanced methods concerning this approach. Visual mechanisms and processes are analysed at several (molecular, cellular, integrative, computational and cognitive) levels by different methodologies (from molecular biology to computation) applied to different living models (from protists to humans, via invertebrates and lower vertebrates). Contents: The Optics of Animal Eyes (M F Land); Rhodopsin-Like Proteins: The Universal and Probably Unique Proteins for Vision (P Gualtieri); The Molecular Design of a Visual Cascade: Molecular Stages of Phototransduction in Drosophila (R Paulsen et al.); Molecular Changes During Primary Visual Pathway Development (K L Moya et al.); Color Vision and Retinal Randomness of the Japanese Yellow Swallowtail Butterfly, Papilio Xuthus (K Arikawa et al.); Patch-Clamping Solitary Visual Cells to Understand the Cellular Mechanisms of Invertebrate Phototransduction (C Musio); Phototransduction in Retinal Rods and Cones (Y Koutalos et al.); Formation of OC ONOCO and OC OFFOCO Ganglion Cell Mosaics (L M Chalupa); Endogenous Nitric Oxide Modulates Signal Transmission from Photoreceptors to On-Center Bipolar Cells in the Rabbit Retina (B Lei & I Perlman); Now You See It, Now You Don't: Shunting Inhibition in Early Vision (L Borg-Graham et al.); Visual Perceptual Learning (N Berardi & A Fiorentini); Functions of the Primate Temporal Lobe Cortical Visual Areas in Invariant Visual Object and Face Recognition (E T Rolls); Vector Code in Neuronal Networks (E N Sokolov); and other papers. Readership: Scientists and postdoctoral students in neurosciences, biophysics and physiology."
Author: Paul A. Hargrave
Publisher: Springer Science & Business Media
ISBN: 3642764827
Category : Science
Languages : en
Pages : 317
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Book Description
This book deals with the mechanism of signal transduction in vertebrate and invertebrate photoreceptors. It contains contributions on the structure and function of rhodopsin or other G-coupled receptors, on the regulation of second messengers by enzyme cascade, the role of Ca2+ in light adaptation, control of ionic channels in photoreceptor cells.
