Molecular Dynamics Simulations of Substance P and ACTH Peptides in Membrane Mimetic Environments PDF Download
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Author: Troy Wayne Wymore
Publisher:
ISBN:
Category : Molecular dynamics
Languages : en
Pages : 314
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Book Description
The peptides Substance P and Substance P(Tyr-8) were studied by molecular dynamics (MD) simulations in two membrane mimetic environments, (1) a biphasic solvent cell made up of carbon tetrachloride molecules and water molecules, and (2) an explicit sodium dodecylsulfate (SDS) micelle. MD simulations of adrenocorticotropin (ACTH[1-10]) were also performed in an SDS micelle. It was proposed that these peptides interact with their receptors via a membrane-mediated mechanism. The analysis of the MD simulation includes (1) the peptide's orientation with respect to the membrane mimetic surface, (2) the peptide backbone hydration, hydrogen bonding and secondary structures, (3) sidechain hydrophobicity and location from the micelle center-of-mass, (4) interaction of the peptides with the micelle headgroups, and (5) the dynamics of the peptide backbone. Comparison to experiments carried out in our lab and others is also presented. The MD simulation of a solvated dodecylphosphocholine (DPC) micelle, a commonly used membrane mimetic, was performed. The analysis includes the micelle shape and shape fluctuations, conformational properties of the lipid chains, interaction of the lipids with water molecules, and the dynamics of the lipid chains.
Author: Troy Wayne Wymore
Publisher:
ISBN:
Category : Molecular dynamics
Languages : en
Pages : 314
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Book Description
The peptides Substance P and Substance P(Tyr-8) were studied by molecular dynamics (MD) simulations in two membrane mimetic environments, (1) a biphasic solvent cell made up of carbon tetrachloride molecules and water molecules, and (2) an explicit sodium dodecylsulfate (SDS) micelle. MD simulations of adrenocorticotropin (ACTH[1-10]) were also performed in an SDS micelle. It was proposed that these peptides interact with their receptors via a membrane-mediated mechanism. The analysis of the MD simulation includes (1) the peptide's orientation with respect to the membrane mimetic surface, (2) the peptide backbone hydration, hydrogen bonding and secondary structures, (3) sidechain hydrophobicity and location from the micelle center-of-mass, (4) interaction of the peptides with the micelle headgroups, and (5) the dynamics of the peptide backbone. Comparison to experiments carried out in our lab and others is also presented. The MD simulation of a solvated dodecylphosphocholine (DPC) micelle, a commonly used membrane mimetic, was performed. The analysis includes the micelle shape and shape fluctuations, conformational properties of the lipid chains, interaction of the lipids with water molecules, and the dynamics of the lipid chains.
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 852
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Book Description
Author: P. Somasundaran
Publisher: CRC Press
ISBN: 9780849396045
Category : Science
Languages : en
Pages : 1148
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Book Description
Author:
Publisher:
ISBN:
Category : Dissertation abstracts
Languages : en
Pages : 848
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Book Description
Author:
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 1850
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Book Description
Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
Author: Ved Srivastava
Publisher:
ISBN: 9780983974154
Category :
Languages : en
Pages : 330
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Book Description
Proceedings of the 24th American Peptide Symposium in Orlando, Florida, June, 2015
Author: Elizabeth H. Harris
Publisher: Academic Press
ISBN: 0080919553
Category : Science
Languages : en
Pages : 483
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Book Description
Dr. Harris has played a major role in the development of this organism as a model system. Her previous version of the Chlamydomonas Sourcebook which published in 1989, has been a classic in the field and is considered required reading for anyone working with this organism. This latest edition has been expanded to include three volumes providing molecular techniques, analysis of the recently sequenced genome, and reviews of the current status of the diverse fields in which Chlamydomonas is used as a model organism. Methods for Chlamydomonas research and best practices for applications in research, including methods for culture, preservation of cultures, preparation of media, lists of inhibitors and other additives to culture media, are included. Additions to this volume also include help with common laboratory problems such as contamination, student demonstrations, and properties of particular strains and mutants. This volume is part of a 3-Volume Set (ISBN: 978-0-12-370873-1) and is also sold individually. Expanded revision of gold standard reference Includes latest advances in research, including completion of the genome Provides broad perspective with studies in cell and molecular biology, genetics, plant physiology and related fields Available as part of a 3-Volume Set or sold individually
Author: Norbert Sewald
Publisher: Wiley-VCH Verlag GmbH
ISBN: 9783527304059
Category : Science
Languages : en
Pages : 562
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Book Description
Peptides play a decisive role in many physiological processes, whether as neurotransmitters, hormones or antibiotics. The rapid developments in peptide research over the past few decades make it almost impossible for newcomers to gain an overview. This means an easily comprehensible yet concise introduction is vital. This unique work covers all the important aspects of this wide-ranging field in one handy volume. On the basis of the fundamental chemical and structural properties of peptides, this reference runs the gamut from analysis, the occurrence and biological importance of peptides, via chemical, biochemical and genetic methods of peptide synthesis, right up to peptide libraries, peptide design and their role in drug research. Yet this book offers much more than a mere overview of the latest level of research. An encyclopedic appendix with valuable data on more than 500 biological relevant peptides and proteins, a comprehensive register and details of further literature references make this the ideal reference for all questions regarding peptide research. For newcomers and specialists alike. On the basis of the fundamental chemical and structural properties of peptides, this reference runs the gamut from analysis, the occurrence and biological importance of peptides.
Author: Stephen Robert Bloom
Publisher:
ISBN:
Category : Gastrointestinal hormones
Languages : en
Pages : 640
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Book Description
Author: Robert Dantzer
Publisher: Springer
ISBN: 3319511521
Category : Medical
Languages : en
Pages : 357
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Book Description
Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book “Inflammation-Associated Depression” is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level.
