Model Systems for the Cytochrome P450 Dependent Mono-oxygenases

Model Systems for the Cytochrome P450 Dependent Mono-oxygenases PDF Author: P. R. Sleath
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Model Systems for the Cytochrome P450 Dependent Mono-oxygenases

Model Systems for the Cytochrome P450 Dependent Mono-oxygenases PDF Author: P. R. Sleath
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Metalloporphyrin-catalysed Model Systems for the Cytochrome P450-dependent Mono-oxygenases

Metalloporphyrin-catalysed Model Systems for the Cytochrome P450-dependent Mono-oxygenases PDF Author: D. N. Mortimer
Publisher:
ISBN:
Category :
Languages : en
Pages :

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EJB Reviews 1989

EJB Reviews 1989 PDF Author: P. Christen
Publisher: Springer
ISBN: 364275189X
Category : Science
Languages : en
Pages : 175

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Book Description
EJB Reviews 1989 offer the collection of all reviews published in the European Journal of Biochemistry in one handy volume. This series of review articles by leading scientists covers emerging and rapidly growing fields of research in fundamental as well as in applied areas of biochemistry, such as medicine, biotechnology, agriculture and nutrition. Novel methodological and technological approaches which stimulate biochemical research are also included. All authors review their field in a very critical, selective, evaluative manner, with emphasis on interdisciplinary aspects wherever possible.

Cytochrome P-450

Cytochrome P-450 PDF Author: Paul Ortiz De Monetllano
Publisher: Springer Science & Business Media
ISBN: 9780306421471
Category : Science
Languages : en
Pages : 572

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Book Description
Major advances have been made in recent years in clarifying the molecular properties of the cytochrome P-450 system. These advances stem, in practical terms, from the generally recognized importance of cytochrome P-450 in the metabolism of drugs and in the bioactivation of xenobiotics to toxic products. The fascinating multiplicity and differential regulation of cytochrome P-450 isozymes, and their ability to catalyze extraordinarily difficult chemical transformations, have independently drawn many chemists and biochemists into the P-450 circle. Progress in the field, from a technical point of view, has been propelled by the de velopment of reliable procedures for the purification of membrane-bound enzymes, by the growing repertoire of molecular biological techniques, and by the development of chemical models that mimic the catalytic action of P-450. As a result, our understanding of the P-450 system is moving from the descriptive, pharmacological level into the tangible realm of atomic detail. The rapid progress and multidisciplinary character of the cytochrome P-450 field, which cuts across the lines that traditionally divide disciplines as diverse as inorganic chemistry and genetics, have created a need for an up-to-date evaluation of the advances that have been made. It is hoped that this book, with its molecular focus on the cytochrome P-450 system, will alleviate this need. The authors of the individual chapters have strived to emphasize recent results without sacrificing the background required to make their chapters comprehensible to informed nonspecialists.

Molecular Mechanisms Of Oxygen Activation

Molecular Mechanisms Of Oxygen Activation PDF Author: Osamu Hayaishi
Publisher: Elsevier
ISBN: 0323143261
Category : Science
Languages : en
Pages : 697

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Book Description
Molecular Mechanisms of Oxygen Activation reviews some of the major advances that have been made in our understanding of the molecular mechanisms underlying oxygen activation, with emphasis on the role of oxygen activation in contemporary biological processes. The biological role of oxygenases in the metabolism of fatty acids and steroids is discussed, along with the functions of heme-containing dioxygenases, a-ketoglutarate-coupled dioxygenases, and pterin-requiring aromatic amino acid hydroxylases. This book is comprised of 14 chapters and begins with an overview of the general properties and biological functions of oxygenases, along with the chemical aspects of oxygen fixation reactions. The reader is then introduced to research concerning fatty acid and steroid oxygenases which has appeared in the literature since 1962, paying particular attention to the mechanism of oxygenation and the biosynthesis and metabolism of steroids. Subsequent chapters explore the biological functions of a variety of oxygenases such as heme-containing dioxygenases, copper-containing oxygenases, flavoprotein oxygenases, and pterin-requiring aromatic amino acid hydroxylases. Superoxide dismutase, cytochrome c oxidase, peroxidase, and bacterial monoxygenases are also considered. This monograph should serve as a valuable reference for biochemists as well as undergraduate and graduate students of biochemistry.

Enzyme Technology

Enzyme Technology PDF Author: Ashok Pandey
Publisher: Springer Science & Business Media
ISBN: 9780387292946
Category : Medical
Languages : en
Pages : 774

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Direct Microbial Conversion of Biomass to Advanced Biofuels

Direct Microbial Conversion of Biomass to Advanced Biofuels PDF Author: Michael E Himmel
Publisher: Elsevier
ISBN: 0444595899
Category : Technology & Engineering
Languages : en
Pages : 423

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Book Description
'Direct Microbial Conversion of Biomass to Advanced Biofuels' is a stylized text that is rich in both the basic and applied sciences. It provides a higher level summary of the most important aspects of the topic, addressing critical problems solved by deep science. Expert users will find new, critical methods that can be applied to their work, detailed experimental plans, important outcomes given for illustrative problems, and conclusions drawn for specific studies that address broad based issues. A broad range of readers will find this to be a comprehensive, informational text on the subject matter, including experimentalists and even CEOs deciding on new business directions. Describes an important new field in biotechnology, the consolidated conversion of lignocellulosic feedstocks to advanced fuels Up-to-date views of promising technologies used in the production of advanced biofuels Presents the newest ideas, well-designed experiments, and outcomes Provides outstanding illustrations from NREL and contributing researchers Contains contributions from leaders in the field that provide numerous examples and insights into the most important aspects of the topic

Advances in Marine Antifouling Coatings and Technologies

Advances in Marine Antifouling Coatings and Technologies PDF Author: Claire Hellio
Publisher: Elsevier
ISBN: 184569631X
Category : Technology & Engineering
Languages : en
Pages : 785

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Book Description
Marine biofouling can be defined as the undesirable accumulation of microorganisms, algae and animals on structures submerged in seawater. From the dawn of navigation, marine biofouling has been a major problem for shipping in such areas as reduced speed, higher fuel consumption and increased corrosion. It also affects industries using off-shore structures such as oil and gas production and aquaculture. Growing concerns about the environmental impact of antifouling coatings has led to major new research to develop more environmentally-friendly alternatives. Advances in marine antifouling coatings and technologies summaries this wealth of research and its practical implications. This book is divided into four sub-sections which discuss: marine fouling organisms and their impact, testing and development of antifouling coatings, developments in chemically-active marine antifouling technologies, and new surface approaches to the control of marine biofouling. It provides an authoritative overview of the recent advances in understanding the biology of fouling organisms, the latest developments on antifouling screening techniques both in the field and in the laboratory, research on safer active compounds and the progress on nontoxic coatings with tailor-made surface properties. With its distinguished editors and international team of contributors, Advances in marine antifouling coatings and technologies is a standard reference for manufacturers of marine antifouling solutions, the shipping industry, oil and gas producers, aquaculture and other industries using offshore structures, and academics researching this important area. Assesses marine antifouling organisms and their impact, including a historical review and directions for future research Discusses developments in antifouling coatings examining chemically-active and new surface approaches Reviews the environmentally friendly alternative of safer active compounds and the progress of non-toxic compounds

Cytochrome P450 Protocols

Cytochrome P450 Protocols PDF Author: Ian R. Phillips
Publisher: Humana Press
ISBN: 9781627033206
Category : Science
Languages : en
Pages : 0

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Book Description
Cytochromes P450 (CYPs) comprise a large superfamily of proteins that are of central importance in the detoxification or activation of a tremendous number of natural and synthetic hydrophobic xenobiotics, including many therapeutic drugs, chemical carcinogens and environmental pollutants. CYPs are important in mediating interactions between an organism and its chemical environment and in the regulation of physiological processes. Cytochrome P450 Protocols, Third Edition focuses on high-throughput methods for the simultaneous analysis of multiple CYPs, substrates or ligands. Although the emphasis is on CYPs of mammalian origin, it reflects an increasing interest in CYPs of bacterial species. Also included are chapters on cytochrome P450 reductase (the redox partner of CYPs) and the flavin-containing monooxygenases (FMOs), and metabolomic and lipidomic approaches for identification of endogenous substrates of CYPs (‘de-orphanizing’ CYP substrates). Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Cytochrome P450 Protocols, Third Edition provides a wide range of techniques accessible to researchers in fields as diverse as biochemistry, molecular biology, pharmacology, toxicology, environmental biology and genetics.

Plant Genomes

Plant Genomes PDF Author: Jean-Nicolas Volff
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805584911
Category : Medical
Languages : en
Pages : 155

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Book Description
Recent major advances in the field of comparative genomics and cytogenomics of plants, particularly associated with the completion of ambitious genome projects, have uncovered astonishing facets of the architecture and evolutionary history of plant genomes. The aim of this book was to review these recent developments as well as their implications in our understanding of the mechanisms which drive plant diversity. New insights into the evolution of gene functions, gene families and genome size are presented, with particular emphasis on the evolutionary impact of polyploidization and transposable elements. Knowledge on the structure and evolution of plant sex chromosomes, centromeres and microRNAs is reviewed and updated. Taken together, the contributions by internationally recognized experts present a panoramic overview of the structural features and evolutionary dynamics of plant genomes.This volume of Genome Dynamics will provide researchers, teachers and students in the fields of biology and agronomy with a valuable source of current knowledge on plant genomes.