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Author: Joachim Kunert
Publisher: Springer
ISBN: 3319312669
Category : Mathematics
Languages : en
Pages : 256
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Book Description
This volume contains pioneering contributions to both the theory and practice of optimal experimental design. Topics include the optimality of designs in linear and nonlinear models, as well as designs for correlated observations and for sequential experimentation. There is an emphasis on applications to medicine, in particular, to the design of clinical trials. Scientists from Europe, the US, Asia, Australia and Africa contributed to this volume of papers from the 11th Workshop on Model Oriented Design and Analysis.
Author: Joachim Kunert
Publisher: Springer
ISBN: 3319312669
Category : Mathematics
Languages : en
Pages : 256
Get Book Here
Book Description
This volume contains pioneering contributions to both the theory and practice of optimal experimental design. Topics include the optimality of designs in linear and nonlinear models, as well as designs for correlated observations and for sequential experimentation. There is an emphasis on applications to medicine, in particular, to the design of clinical trials. Scientists from Europe, the US, Asia, Australia and Africa contributed to this volume of papers from the 11th Workshop on Model Oriented Design and Analysis.
Author: Jesus Lopez-Fidalgo
Publisher: Springer Science & Business Media
ISBN: 3790819522
Category : Mathematics
Languages : en
Pages : 241
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Book Description
This volume contains the proceedings of the 8th Workshop on Model-Oriented Design and Analysis. It offers leading and pioneering work on optimal experimental designs, both from a mathematical/statistical point of view and with regard to real applications. Scientists from all over the world have contributed to this volume. Primary topics are designs for nonlinear models and applications to experimental medicine.
Author: Dariusz Ucinski
Publisher: Springer Science & Business Media
ISBN: 331900218X
Category : Mathematics
Languages : en
Pages : 254
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Book Description
This book collects the proceedings of the 10th Workshop on Model-Oriented Design and Analysis (mODa). A model-oriented view on the design of experiments, which is the unifying theme of all mODa meetings, assumes some knowledge of the form of the data-generating process and naturally leads to the so-called optimum experimental design. Its theory and practice have since become important in many scientific and technological fields, ranging from optimal designs for dynamic models in pharmacological research, to designs for industrial experimentation, to designs for simulation experiments in environmental risk management, to name but a few. The methodology has become even more important in recent years because of the increased speed of scientific developments, the complexity of the systems currently under investigation and the mounting pressure on businesses, industries and scientific researchers to reduce product and process development times. This increased competition requires ever increasing efficiency in experimentation, thus necessitating new statistical designs. This book presents a rich collection of carefully selected contributions ranging from statistical methodology to emerging applications. It primarily aims to provide an overview of recent advances and challenges in the field, especially in the context of new formulations, methods and state-of-the-art algorithms. The topics included in this volume will be of interest to all scientists and engineers and statisticians who conduct experiments.
Author: Alessandro Di Bucchianico
Publisher: Springer Science & Business Media
ISBN: 3790826936
Category : Mathematics
Languages : en
Pages : 239
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Book Description
The volume contains the proceedings of the 7th Workshop on Model-Oriented Design and Analysis which has had the purpose of bringing together leading researchers in Eastern and Western Europe for an in-depth discussion of the optimal design of experiments. The papers are representative of the latest developments concerning non-linear models, computational algorithms and important applications, especially to medical statistics.
Author: Anthony C. Atkinson
Publisher: Springer Science & Business Media
ISBN: 3642575765
Category : Business & Economics
Languages : en
Pages : 288
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Book Description
This book includes many of the papers presented at the 6th International workshop on Model Oriented Data Analysis held in June 2001. This series began in March 1987 with a meeting on the Wartburg near Eisenach (at that time in the GDR). The next four meetings were in 1990 (St Kyrik monastery, Bulgaria), 1992 (Petrodvorets, St Petersburg, Russia), 1995 (Spetses, Greece) and 1998 (Marseilles, France). Initially the main purpose of these workshops was to bring together leading scientists from 'Eastern' and 'Western' Europe for the exchange of ideas in theoretical and applied statistics, with special emphasis on experimental design. Now that the sep aration between East and West is much less rigid, this exchange has, in principle, become much easier. However, it is still important to provide opportunities for this interaction. MODA meetings are celebrated for their friendly atmosphere. Indeed, dis cussions between young and senior scientists at these meetings have resulted in several fruitful long-term collaborations. This intellectually stimulating atmosphere is achieved by limiting the number of participants to around eighty, by the choice of a location in which communal living is encour aged and, of course, through the careful scientific direction provided by the Programme Committee. It is a tradition of these meetings to provide low cost accommodation, low fees and financial support for the travel of young and Eastern participants. This is only possible through the help of sponsors and outside financial support was again important for the success of the meeting.
Author: Alessandra Giovagnoli
Publisher: Springer Science & Business Media
ISBN: 3790824100
Category : Mathematics
Languages : en
Pages : 259
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Book Description
Statisticians and experimentalists will find the latest trends in optimal experimental design research. Some papers are pioneering contributions, leading to new open research problems. It is a colection of peer reviewed papers.
Author: Nina Golyandina
Publisher: Springer
ISBN: 3662573806
Category : Mathematics
Languages : en
Pages : 284
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Book Description
This comprehensive and richly illustrated volume provides up-to-date material on Singular Spectrum Analysis (SSA). SSA is a well-known methodology for the analysis and forecasting of time series. Since quite recently, SSA is also being used to analyze digital images and other objects that are not necessarily of planar or rectangular form and may contain gaps. SSA is multi-purpose and naturally combines both model-free and parametric techniques, which makes it a very special and attractive methodology for solving a wide range of problems arising in diverse areas, most notably those associated with time series and digital images. An effective, comfortable and accessible implementation of SSA is provided by the R-package Rssa, which is available from CRAN and reviewed in this book. Written by prominent statisticians who have extensive experience with SSA, the book (a) presents the up-to-date SSA methodology, including multidimensional extensions, in language accessible to a large circle of users, (b) combines different versions of SSA into a single tool, (c) shows the diverse tasks that SSA can be used for, (d) formally describes the main SSA methods and algorithms, and (e) provides tutorials on the Rssa package and the use of SSA. The book offers a valuable resource for a very wide readership, including professional statisticians, specialists in signal and image processing, as well as specialists in numerous applied disciplines interested in using statistical methods for time series analysis, forecasting, signal and image processing. The book is written on a level accessible to a broad audience and includes a wealth of examples; hence it can also be used as a textbook for undergraduate and postgraduate courses on time series analysis and signal processing.
Author: Eduardo Gil
Publisher: Springer
ISBN: 3319738488
Category : Technology & Engineering
Languages : en
Pages : 897
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Book Description
This book is a tribute to Professor Pedro Gil, who created the Department of Statistics, OR and TM at the University of Oviedo, and a former President of the Spanish Society of Statistics and OR (SEIO). In more than eighty original contributions, it illustrates the extent to which Mathematics can help manage uncertainty, a factor that is inherent to real life. Today it goes without saying that, in order to model experiments and systems and to analyze related outcomes and data, it is necessary to consider formal ideas and develop scientific approaches and techniques for dealing with uncertainty. Mathematics is crucial in this endeavor, as this book demonstrates. As Professor Pedro Gil highlighted twenty years ago, there are several well-known mathematical branches for this purpose, including Mathematics of chance (Probability and Statistics), Mathematics of communication (Information Theory), and Mathematics of imprecision (Fuzzy Sets Theory and others). These branches often intertwine, since different sources of uncertainty can coexist, and they are not exhaustive. While most of the papers presented here address the three aforementioned fields, some hail from other Mathematical disciplines such as Operations Research; others, in turn, put the spotlight on real-world studies and applications. The intended audience of this book is mainly statisticians, mathematicians and computer scientists, but practitioners in these areas will certainly also find the book a very interesting read.
Author: KyungMann Kim
Publisher: CRC Press
ISBN: 1498714641
Category : Mathematics
Languages : en
Pages : 655
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Book Description
Statistical concepts provide scientific framework in experimental studies, including randomized controlled trials. In order to design, monitor, analyze and draw conclusions scientifically from such clinical trials, clinical investigators and statisticians should have a firm grasp of the requisite statistical concepts. The Handbook of Statistical Methods for Randomized Controlled Trials presents these statistical concepts in a logical sequence from beginning to end and can be used as a textbook in a course or as a reference on statistical methods for randomized controlled trials. Part I provides a brief historical background on modern randomized controlled trials and introduces statistical concepts central to planning, monitoring and analysis of randomized controlled trials. Part II describes statistical methods for analysis of different types of outcomes and the associated statistical distributions used in testing the statistical hypotheses regarding the clinical questions. Part III describes some of the most used experimental designs for randomized controlled trials including the sample size estimation necessary in planning. Part IV describe statistical methods used in interim analysis for monitoring of efficacy and safety data. Part V describe important issues in statistical analyses such as multiple testing, subgroup analysis, competing risks and joint models for longitudinal markers and clinical outcomes. Part VI addresses selected miscellaneous topics in design and analysis including multiple assignment randomization trials, analysis of safety outcomes, non-inferiority trials, incorporating historical data, and validation of surrogate outcomes.
Author: John O'Quigley
Publisher: CRC Press
ISBN: 1351648020
Category : Mathematics
Languages : en
Pages : 390
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Book Description
Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials gives a thorough presentation of state-of-the-art methods for early phase clinical trials. The methodology of clinical trials has advanced greatly over the last 20 years and, arguably, nowhere greater than that of early phase studies. The need to accelerate drug development in a rapidly evolving context of targeted therapies, immunotherapy, combination treatments and complex group structures has provided the stimulus to these advances. Typically, we deal with very small samples, sequential methods that need to be efficient, while, at the same time adhering to ethical principles due to the involvement of human subjects. Statistical inference is difficult since the standard techniques of maximum likelihood do not usually apply as a result of model misspecification and parameter estimates lying on the boundary of the parameter space. Bayesian methods play an important part in overcoming these difficulties, but nonetheless, require special consideration in this particular context. The purpose of this handbook is to provide an expanded summary of the field as it stands and also, through discussion, provide insights into the thinking of leaders in the field as to the potential developments of the years ahead. With this goal in mind we present: An introduction to the field for graduate students and novices A basis for more established researchers from which to build A collection of material for an advanced course in early phase clinical trials A comprehensive guide to available methodology for practicing statisticians on the design and analysis of dose-finding experiments An extensive guide for the multiple comparison and modeling (MCP-Mod) dose-finding approach, adaptive two-stage designs for dose finding, as well as dose–time–response models and multiple testing in the context of confirmatory dose-finding studies. John O’Quigley is a professor of mathematics and research director at the French National Institute for Health and Medical Research based at the Faculty of Mathematics, University Pierre and Marie Curie in Paris, France. He is author of Proportional Hazards Regression and has published extensively in the field of dose finding. Alexia Iasonos is an associate attending biostatistician at the Memorial Sloan Kettering Cancer Center in New York. She has over one hundred publications in the leading statistical and clinical journals on the methodology and design of early phase clinical trials. Dr. Iasonos has wide experience in the actual implementation of model based early phase trials and has given courses in scientific meetings internationally. Björn Bornkamp is a statistical methodologist at Novartis in Basel, Switzerland, researching and implementing dose-finding designs in Phase II clinical trials. He is one of the co-developers of the MCP-Mod methodology for dose finding and main author of the DoseFinding R package. He has published numerous papers on dose finding, nonlinear models and Bayesian statistics, and in 2013 won the Royal Statistical Society award for statistical excellence in the pharmaceutical industry.
