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Author: Robert E. Kohler
Publisher: Cambridge University Press
ISBN: 9780521243124
Category : Medical
Languages : en
Pages : 426
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Book Description
This penetrating case study of institution building and entrepreneurship in science shows how a minor medical speciality evolved into a large and powerful academic discipline. Drawing extensively on little-used archival sources, the author analyses in detail how biomedical science became a central part of medical training and practice. The book shows how biochemistry was defined as a distinct discipline by the programmatic vision of individual biochemists and of patrons and competitors in related disciplines. It shows how discipline builders used research programmes as strategies that they adapted to the opportunities offered by changing educational markets and national medical reform movements in the United States, Britain and Germany. The author argues that the priorities and styles of various departments and schools of biochemistry reflect systematic social relationships between that discipline and biology, chemistry and medicine. Science is shaped by its service roles in particular local contexts: This is the central theme. The author's view of the political economy of modern science will be of interest to historians and social scientists, scientific and medical practitioners, and anyone interested in the ecology of knowledge in scientific institutions and professions.
Author: Camille Georges Wermuth
Publisher: Elsevier
ISBN: 0080497772
Category : Science
Languages : en
Pages : 792
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Book Description
The Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry. The successful first edition was nicknamed "The Bible" by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs. Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists who must acquire a strong knowledge of medicinal chemistry as they enter the industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. The only book available dealing with the practical aspects of medicinal chemistry Serves as a complete guide to the drug discovery process, from conception of the molecules to drug production Updated chapters devoted to the discovery of new lead compounds, including combinatorial chemistry
Author: Robert E. Kohler
Publisher: Cambridge University Press
ISBN: 9780521243124
Category : Medical
Languages : en
Pages : 426
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Book Description
This penetrating case study of institution building and entrepreneurship in science shows how a minor medical speciality evolved into a large and powerful academic discipline. Drawing extensively on little-used archival sources, the author analyses in detail how biomedical science became a central part of medical training and practice. The book shows how biochemistry was defined as a distinct discipline by the programmatic vision of individual biochemists and of patrons and competitors in related disciplines. It shows how discipline builders used research programmes as strategies that they adapted to the opportunities offered by changing educational markets and national medical reform movements in the United States, Britain and Germany. The author argues that the priorities and styles of various departments and schools of biochemistry reflect systematic social relationships between that discipline and biology, chemistry and medicine. Science is shaped by its service roles in particular local contexts: This is the central theme. The author's view of the political economy of modern science will be of interest to historians and social scientists, scientific and medical practitioners, and anyone interested in the ecology of knowledge in scientific institutions and professions.
Author: Marc Harrold
Publisher: ASHP
ISBN: 1585283649
Category : Medical
Languages : en
Pages : 405
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Book Description
Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group. Key features include: • Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups. • How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism. • Numerous examples and expanded discussions for complex concepts. • Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice. • An overview of structure activity relationships (SARs) and concepts that govern drug design. • Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix. Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry. About the Authors Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy. Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.
Author: Andrejus Korolkovas
Publisher: Wiley-Interscience
ISBN:
Category : Medical
Languages : en
Pages : 1220
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Book Description
This text/reference presents fundamental aspects of medicinal chemistry and contains comprehensive information on approximately 5,000 drugs currently in use, describing their therapeutic uses, their mechanisms of action, and their main side and harmful effects. Employs the latest World Health Organization (WHO) pharmacological classification and provides extensive information for drugs on WHO's latest list of basic or essential pharmaceuticals, including history: chemical, trade and generic names; chemical structure; obtention; physical and chemical properties; mechanisms of action; therapeutic uses; adverse reactions; biotransformation; chemical and pharmacological incompatibilities; bioavailability; dosage; storage; and assay.
Author: Camille Georges Wermuth
Publisher: Elsevier
ISBN: 012417213X
Category : Science
Languages : en
Pages : 903
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Book Description
The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com
Author: Victor E. Marquez
Publisher: CRC Press
ISBN: 1000462943
Category : Medical
Languages : en
Pages : 566
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Book Description
The Ups and Downs in Drug Design: Adventures in Medicinal Chemistry highlights the necessity for an integrative approach in medicinal chemistry and chemical biology. As medicinal chemistry is not a monolithic science, it is important to emphasize the other various disciplines that are required for successful drug design. This book presents the author’s own personal experience in this field and describes the "ups" and "downs" that come with drug discovery. It is an excellent companion text for graduate and postgraduate students who would like further insight into the parameters of drug design, including the challenges that come with the project. Key Features Illustrates "real-life" examples in medicinal chemistry Integrates the use of physical, chemical, and biological concepts that are important in drug design Highlights the "ups" and "downs" that come with drug discovery Aims to inspire students who may be struggling with the challenges and thought process in drug design Intends to be an excellent companion text for graduate and postgraduate students
Author: Graham L. Patrick
Publisher: Oxford University Press, USA
ISBN: 0199697396
Category : Medical
Languages : en
Pages : 814
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Book Description
This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.
Author: Thomas Nogrady
Publisher: Oxford University Press
ISBN: 0190282967
Category : Medical
Languages : en
Pages : 664
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Book Description
Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.
Author: Frank D. King
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 488
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Book Description
This is an valuable introduction to medicinal chemistry for new graduates and PhDs. It will also serve to update more experienced scientists on the newer technologies in the field.
Author: Enzo Alessio
Publisher: John Wiley & Sons
ISBN: 352763312X
Category : Science
Languages : en
Pages : 625
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Book Description
This book gives a comprehensive overview about medicinal inorganic chemistry. Topics like targeting strategies, mechanism of action, Pt-based antitumor drugs, radiopharmaceuticals are covered in detail and offer the reader an in-depth overview about this important topic.
