Investigation of Mouse Mammary Tumor Virus (MMTV)-Like Gene Sequences in Canine and Feline Mammary Tumors PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Investigation of Mouse Mammary Tumor Virus (MMTV)-Like Gene Sequences in Canine and Feline Mammary Tumors PDF full book. Access full book title Investigation of Mouse Mammary Tumor Virus (MMTV)-Like Gene Sequences in Canine and Feline Mammary Tumors by . Download full books in PDF and EPUB format.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
Author: P.K. Vogt
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 120
Get Book Here
Book Description
Author: Edward Robert Medeiros
Publisher:
ISBN:
Category : Mice
Languages : en
Pages : 370
Get Book Here
Book Description
Author: Deepa Shankar
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
Mouse mammary tumor virus (MMTV) is used as an insertion mutagen in transgenic mice that express the Wnt1 gene in their mammary gland, to produce additional events like activation of a second oncogene. Cloning cellular sequences flanking new proviral insertion from tumor 76 identified a common insertion locus for MMTV. Further analyses of this region identified Fgf3 as the gene activated over a long distance by MMTV. Fgf8 is another oncogene that I identified was activated in 10% of the mammary tumors form these infected Wnt1 transgenic mice. Fgf8 encodes for at least seven different protein isoforms, three of which were isolated by us. These three isoforms (Fgf8a, b & c) differ in their NIH3T3 cell transforming abilities. Fgf8b induces programmed cell death of mammary epithelial cells. This apoptotic property is not confined to Fgf8b but is also seen when mammary epithelial cells are treated with purified human FGF proteins (FGF 1, 2, 4, 6, & 9). Over expression of BCL2 in the mammary epithelial cells delays the onset of FGF induced apoptosis. Female transgenic mice expressing the Fgf8 gene in the mammary gland developed tumors with a latency of 5-6 months. These tumors were found to be adenocarcinomas: benign adenomas to invasive ductal carcinomas. Northern analyses of tumor RNAs show high expression of the transgene.
Author: David William Morris
Publisher:
ISBN:
Category :
Languages : en
Pages : 156
Get Book Here
Book Description
Author: Deepa Bhavani Shankar
Publisher:
ISBN:
Category :
Languages : en
Pages : 334
Get Book Here
Book Description
Mouse mammary tumor virus (MMTV) is used as an insertion mutagen in transgenic mice that express the Wnt1 gene in their mammary gland, to produce additional events like activation of a second oncogene. Cloning cellular sequences flanking new proviral insertion from tumor 76 identified a common insertion locus for MMTV. Further analyses of this region identified Fgf3 as the gene activated over a long distance by MMTV. Fgf8 is another oncogene that I identified was activated in 10% of the mammary tumors form these infected Wnt1 transgenic mice. Fgf8 encodes for at least seven different protein isoforms, three of which were isolated by us. These three isoforms (Fgf8a, b & c) differ in their NIH3T3 cell transforming abilities. Fgf8b induces programmed cell death of mammary epithelial cells. This apoptotic property is not confined to Fgf8b but is also seen when mammary epithelial cells are treated with purified human FGF proteins (FGF 1, 2, 4, 6, & 9). Over expression of BCL2 in the mammary epithelial cells delays the onset of FGF induced apoptosis. Female transgenic mice expressing the Fgf8 gene in the mammary gland developed tumors with a latency of 5-6 months. These tumors were found to be adenocarcinomas: benign adenomas to invasive ductal carcinomas. Northern analyses of tumor RNAs show high expression of the transgene.
Author: Kiho Cho
Publisher:
ISBN:
Category :
Languages : en
Pages : 372
Get Book Here
Book Description
Author: Roeland Nusse
Publisher:
ISBN:
Category :
Languages : en
Pages : 142
Get Book Here
Book Description
Author: Teri Jo Liegler
Publisher:
ISBN:
Category :
Languages : en
Pages : 268
Get Book Here
Book Description
Author: Lu Yao
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
