Introductory Review on Sirtuins in Biology, Aging, and Disease PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Introductory Review on Sirtuins in Biology, Aging, and Disease PDF full book. Access full book title Introductory Review on Sirtuins in Biology, Aging, and Disease by Leonard Guarente. Download full books in PDF and EPUB format.
Author: Leonard Guarente
Publisher: Academic Press
ISBN: 012813500X
Category : Science
Languages : en
Pages : 222
Get Book Here
Book Description
Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. - Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease - Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics - Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses
Author: Leonard Guarente
Publisher: Academic Press
ISBN: 012813500X
Category : Science
Languages : en
Pages : 222
Get Book Here
Book Description
Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. - Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease - Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics - Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses
Author: Tiago F. Outeiro
Publisher: Frontiers E-books
ISBN: 2889191176
Category :
Languages : en
Pages : 101
Get Book Here
Book Description
Sirtuins comprise a family of NAD+-dependent enzymes that have been shown to impact longevity in a number of eukaryotic organisms. Sir2 (Silent Information Regulator 2) was the first sirtuin protein discovered. The discovery that Sir2 requires NAD+ for its activity suggested a link between Sir2 activity and the phenomenon of caloric restriction in prolonging longevity. This link was strengthened by the observation that lifespan extension by caloric restriction requires Sir2 protein. Under conditions of caloric restriction, NAD+ levels are high, Sir2 is activated, and the rate of aging is decreased. These effects have been replicated in invertebrate organisms, where a close structural and functional homologue of Sir2 was found in C. elegans and Drosophila. The sirtuin-dependent effects on metabolism and ageing, observed in lower organisms, have ignited intensive investigation of their biological and therapeutic roles in mammals. There are seven known mammalian sirtuins, SIRTs 1-7, the most studied of which is SIRT1, a close structural and functional homologue of yeast Sir2. Enhancement of organismal longevity and other health-promoting effects of mammalian SIRT1 have frequently been attributed to the regulation of metabolism. A recognized molecular link between metabolism and aging stimulated a firestorm of investigations, aiming to combat metabolic and age-dependent human diseases. It has become clear, however, that the sirtuin family of proteins regulates a diverse repertoire of cellular functions in mammals. Mounting evidence implicating SIRT1 in important clinical indications, such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease, suggest that modality as attractive therapeutic target. Subsequently, drug discovery and development, targeting sirtuin activation, has been intensified in the recent years. Despite rapid progress and accumulation of new data, the biological roles of other mammalian sirtuins have been less studied and remain poorly understood. There are several important questions that remain to be addressed. What are the functions of sirtuins in different cell types and tissues? Are all sirtuins involved in the regulation of metabolism and aging? What is the functional relationship between different sirtuins? What are the mechanisms of regulation of sirtuin activities? What is the role of sirtuins in disease and therapy? This issue aims to address these and other critical questions, relevant to Research Topic on sirtuin biology and therapeutics. To that end the issue solicits expert opinions of sirtuin research on structural biology, biochemistry, cell biology, animal genetics, pharmacology, medicinal chemistry and drug discovery, and on areas of investigation studying human conditions, like diabetes, cancer, cardio-vascular, and neutodegeneration. Of particular interest are the new methods and assays to study sirtuins in various organisms and developing sirtuin-based therapeutics. Furthermore, we propose to encourage contributors to discuss new concepts and paradigms, and to express their perspectives on the future development of the sirtuin research field. Altogether, we believe this issue provides a unique opportunity for comprehensive and diverse coverage of the topic, and will be of broad interest for the journal’s readership.
Author: Chuong Pham-Huy
Publisher: CRC Press
ISBN: 1000563596
Category : Health & Fitness
Languages : en
Pages : 667
Get Book Here
Book Description
Food and Lifestyle in Health and Disease gathers information on various food types providing an explanation of their nutrient composition, sources, roles, and mechanisms in health and diseases. To obtain good health practices and prevent diseases, it is necessary to understand links in the relationship of food, lifestyle, environment, and health. This book is a vital source for research topics related to these issues, including the following: Analysis of various types of food and lifestyles for the prevention and treatment of diseases and disorders, including cardiovascular disorders, cancers, neurodegenerative diseases, diabetes, hypertension, and obesity. The influences of environmental pollution, synergistic effects of different foods, and synergy of foods with physical activity or medicine. The roles of animal, fungal, and plant source foods in human health and disease. This book is appropriate for health-conscious users, health care providers and practitioners, teachers, and researchers.
Author: David A. Sinclair
Publisher: Atria Books
ISBN: 1501191977
Category : Science
Languages : en
Pages : 432
Get Book Here
Book Description
A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.” —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.
Author:
Publisher: Academic Press
ISBN: 9780128122617
Category : Science
Languages : en
Pages : 0
Get Book Here
Book Description
Sirtuins in Health and Disease, Volume 154 presents the reactions catalyzed by sirtuins in terms of their unique coenzyme NAD+-dependent catalytic mechanisms, the ways to elucidate these mechanisms, and the design of the inhibitory compounds against the sirtuin-catalyzed reactions as potential therapeutic agents for human diseases. Sections cover the concepts and chemical tools in sirtuin research, SIRT4 and SIRT7, the regulatory effects of NAD metabolic pathways on sirtuin activity, sirtuins as modifiers of Huntington's Disease (HD) pathology, parasite sirtuins as targets for novel chemotherapeutic agents, targeting sirtuins - substrate specificity and inhibitor design, and chemical probes in sirtuin research. This book focuses on the outstanding issues in the sirtuin field and implications for future sirtuin research.
Author: Qianjin Lu
Publisher: Academic Press
ISBN: 0128012722
Category : Science
Languages : en
Pages : 525
Get Book Here
Book Description
Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable. Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy
Author: Ian Stuart-Hamilton
Publisher: Cambridge University Press
ISBN: 1139500171
Category : Psychology
Languages : en
Pages : 459
Get Book Here
Book Description
With the world's population getting increasingly older, there has never been a more pressing need for the study of old age and ageing. An Introduction to Gerontology provides a wide-ranging introduction to this important topic. By assuming no prior expert knowledge and avoiding jargon, this book will guide students through all the main subjects in gerontology, covering both traditional areas, such as biological and social ageing, and more contemporary areas, such as technology, the arts and sexuality. An Introduction to Gerontology is written by a team of international authors with multidisciplinary backgrounds who draw evidence from a variety of different perspectives and traditions.
Author: Leonard Guarente
Publisher: CSHL Press
ISBN: 9780879696528
Category : Family & Relationships
Languages : en
Pages : 172
Get Book Here
Book Description
Ageless Questis a personal, sometimes controversial, account of the pursuit of a genetic †̃cure' for aging by an expert in the field. The author is the Novartis Professor of Biology at the Massachusetts Institute of Technology. Aging has always been regarded as a highly complex process with many degenerative changes leading to the cessation of life. But recent research has identified a relatively simple mechanism that governs the pace of aging. Lenny Guarente's Ageless Questis a scientific detective story for the baby boom generation. It offers an insider's view of an area of potentially astonishing high reward—and equally high risk.
Author: Panayiotis Vlamos
Publisher: Springer Nature
ISBN: 3030787877
Category : Medical
Languages : en
Pages : 423
Get Book Here
Book Description
The 4th World Congress on Genetics, Geriatrics, and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. The relation between genetics and its effect on several diseases are thoroughly examined in this volume. This volume focuses on the sessions from the conference on Genetics and Neurodegenerative Diseases.
Author: Raymond J. Cronise
Publisher: Penguin
ISBN: 1465497595
Category : Health & Fitness
Languages : en
Pages : 256
Get Book Here
Book Description
Fancy optimizing your health and living a longer and fuller life with plant-based recipes? Then this may be the book for you! Looking to adopt a healthy vegetarian diet this New Year but don’t know where to start? No worries, we’ve got you covered! Authors and leading plant-based nutrition experts Julieanna Hever and Ray Cronise have spent over a decade researching diet and nutrition, analyzing longevity studies, and helping their clients achieve sustainable, lasting health benefits by adopting a whole-food, plant-based diet. So what are you waiting for? Dive straight in to discover: - 100 delicious and nutritious plant-based recipes for the whole family to love - Evidence-based research on the scientific underpinnings of the healthspan diet - Easy-to-follow guidelines simplify food choices without being restrictive - Beautifully photographed recipes offer options and flexibility In The Healthspan Solution, they share the simple and effective diet that has allowed their clients to lose weight, reverse disease, reduce or eliminate medication use, and achieve optimal health. This healthy recipe cookbook examines the health risks posed by typical Western eating habits and explains how a diet rich in vegetables, fruits, whole grains, legumes, mushrooms, nuts, seeds, herbs and spices can lead to lower blood pressure, a healthy gut, weight loss and longer life expectancy. Their flexible, customizable approach to eating challenges the conventional idea of breakfast, lunch, and dinner and focuses instead on soups, salads, sides, and sweets. With 100 delicious recipes to choose from, this healthy cookbook ensures that adopting a plant-based lifestyle is simple and sustainable. Still not sure? Check out our riveting reviews below and discover just how much The HealthSpan Solution has changed people’s lives for the better! “Ray and Julieanna didn’t write a fad diet book. It’s about making a permanent lifestyle transformation. The magic is I still can eat anything I want. The trick is what I want has profoundly changed. They did the trick for me and saved my life—now let them help you.”—Penn Jillette, Las Vegas entertainer and magician “Ray is a scientific visionary and Julieanna is a master of nutrition. Together they’ve written a fact-based recipe book for longevity that belongs in every kitchen. Buy it.”—David Sinclair, PhD, AO, Professor of Genetics, Harvard Medical School “Working with Julieanna and Ray has given me a profoundly new understanding of how food impacts health and how what we eat is often dictated by social influences. I’m excited to be a part of their effort to push to this message out to a far bigger audience.”—Cyan Banister, angel investor and entrepreneur “Julieanna and Ray are an incredible team. While others have sought to demonstrate the adequacy of an exclusively plant-sourced diet, they teach how it can be superior and mimics longevity research.”—Rich Roll, plant-powered ultra athlete and author
