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Author: Bo Xu
Publisher:
ISBN:
Category :
Languages : en
Pages : 124
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Book Description
Magnetic resonance imaging (MRI) is a widely used non-invasive imaging technique, with rich contrast for interrogation of tissue physiology and pathology. MRI can be used to examine hemodynamic conditions like perfusion and oxygenation qualitatively and quantitatively. This dissertation reports new techniques that employ dynamic imaging and quantitative susceptibility mapping (QSM) to overcome technical challenges for improved MRI perfusion imaging and oxygenation quantification. Perfusion imaging after gadolinium contrast agent administration is a common clinical practice, where dynamic MRI technique is used to track contrast bolus. It is desirable to have high temporal resolution to capture blood dynamics, as well as high spatial resolution to depict small lesions. Unfortunately, these requirements are limited by hardware and physiological conditions. In this dissertation, a dynamic MRI technique was realized, using fast spiral acquisition and a constrained image reconstruction algorithm, to achieve high temporal-spatial resolution for liver perfusion imaging. Tissue susceptibility provides unique contrast in MRI. Recent development of QSM technique has been applied in various clinical applications. In this dissertation, the dynamic imaging method was extended to multi-echo acquisition and combined with QSM to map gadolinium contrast agent concentration during the first passage for cerebral perfusion mapping. Blood oxygenation is determined by the amount of deoxyhemoglobin in red blood cell. Magnetic susceptibility of deoxyhemoglobin is a source of MR contrast for imaging oxygenation. This dissertation reports correction schemes in both data acquisition and image reconstruction of QSM for improved blood oxygenation quantification.
Author: Bo Xu
Publisher:
ISBN:
Category :
Languages : en
Pages : 124
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Book Description
Magnetic resonance imaging (MRI) is a widely used non-invasive imaging technique, with rich contrast for interrogation of tissue physiology and pathology. MRI can be used to examine hemodynamic conditions like perfusion and oxygenation qualitatively and quantitatively. This dissertation reports new techniques that employ dynamic imaging and quantitative susceptibility mapping (QSM) to overcome technical challenges for improved MRI perfusion imaging and oxygenation quantification. Perfusion imaging after gadolinium contrast agent administration is a common clinical practice, where dynamic MRI technique is used to track contrast bolus. It is desirable to have high temporal resolution to capture blood dynamics, as well as high spatial resolution to depict small lesions. Unfortunately, these requirements are limited by hardware and physiological conditions. In this dissertation, a dynamic MRI technique was realized, using fast spiral acquisition and a constrained image reconstruction algorithm, to achieve high temporal-spatial resolution for liver perfusion imaging. Tissue susceptibility provides unique contrast in MRI. Recent development of QSM technique has been applied in various clinical applications. In this dissertation, the dynamic imaging method was extended to multi-echo acquisition and combined with QSM to map gadolinium contrast agent concentration during the first passage for cerebral perfusion mapping. Blood oxygenation is determined by the amount of deoxyhemoglobin in red blood cell. Magnetic susceptibility of deoxyhemoglobin is a source of MR contrast for imaging oxygenation. This dissertation reports correction schemes in both data acquisition and image reconstruction of QSM for improved blood oxygenation quantification.
Author: Nicole Seiberlich
Publisher: Academic Press
ISBN: 0128170581
Category : Computers
Languages : en
Pages : 1094
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Book Description
Quantitative Magnetic Resonance Imaging is a 'go-to' reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: - The basic physics behind tissue property mapping - How to implement basic pulse sequences for the quantitative measurement of tissue properties - The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* - The pros and cons for different approaches to mapping perfusion - The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor - maps and more complex representations of diffusion - How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed - How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance - Fingerprinting can be used to accelerate or improve tissue property mapping schemes - How tissue property mapping is used clinically in different organs - Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds - Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements - Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges - Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches
Author: Matt A. Bernstein
Publisher: Elsevier
ISBN: 0080533124
Category : Mathematics
Languages : en
Pages : 1041
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Book Description
Magnetic Resonance Imaging (MRI) is among the most important medical imaging techniques available today. There is an installed base of approximately 15,000 MRI scanners worldwide. Each of these scanners is capable of running many different "pulse sequences", which are governed by physics and engineering principles, and implemented by software programs that control the MRI hardware. To utilize an MRI scanner to the fullest extent, a conceptual understanding of its pulse sequences is crucial. Handbook of MRI Pulse Sequences offers a complete guide that can help the scientists, engineers, clinicians, and technologists in the field of MRI understand and better employ their scanner. - Explains pulse sequences, their components, and the associated image reconstruction methods commonly used in MRI - Provides self-contained sections for individual techniques - Can be used as a quick reference guide or as a resource for deeper study - Includes both non-mathematical and mathematical descriptions - Contains numerous figures, tables, references, and worked example problems
Author: Barry L. Zaret
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 704
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Book Description
This latest edition of NUCLEAR CARDIOLOGY provides up-to-the-minute information on current and future uses of radionuclides in imaging diagnosis of the heart. Thoroughly revised and updated, it contains practical information on radiopharmaceuticals, tracer kinetics, instrumentation, ventricular function, perfusion, acute ischemic syndrome, viability, and metabolic images, as well as a discussion of the role of nuclear cardiology in a changing health care system. Practitioners in nuclear medicine, radiology, and cardiology will benefit from having current information on a wide range of topics in one focused reference. Provides highly detailed and comprehensive information in one convenient resource Includes more than 600 images and illustrations to aid comprehension Incorporates the knowledge of internationally recognized authors who are experts in the field Discusses a broad spectrum of nuclear cardiology applications to help you gain a better perspective on contemporary cardiac nuclear medicine
Author: John M. Walker
Publisher: Springer Science & Business Media
ISBN: 1603273751
Category : Science
Languages : en
Pages : 1105
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Book Description
Recent advances in the biosciences have led to a range of powerful new technologies, particularly nucleic acid, protein and cell-based methodologies. The most recent insights have come to affect how scientists investigate and define cellular processes at the molecular level. This book expands upon the techniques included in the first edition, providing theory, outlines of practical procedures, and applications for a range of techniques. Written by a well-established panel of research scientists, the book provides an up-to-date collection of methods used regularly in the authors’ own research programs.
Author: Ulrich Flogel
Publisher: CRC Press
ISBN: 1315340933
Category : Medical
Languages : en
Pages : 426
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Book Description
Over the past decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community owing to the unique properties of fluorinated materials and the 19F nucleus. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body and thus there is no background signal. Fluorine-containing compounds are ideal tracer labels for a wide variety of MRI applications. Moreover, the chemical shift and nuclear relaxation rate can be made responsive to physiology via creative molecular design. This book is an interdisciplinary compendium that details cutting-edge science and medical research in the emerging field of 19F MRI. Edited by Ulrich Flögel and Eric Ahrens, two prominent MRI researchers, this book will appeal to investigators involved in MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.
Author: Yoshimi Anzai
Publisher: Thieme
ISBN: 1604067292
Category : Medical
Languages : en
Pages : 519
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Book Description
An image-rich text on neuroimaging of trauma patients Imaging of Traumatic Brain Injury is a radiological reference that covers all aspects of neurotrauma imaging and provides a clinical overview of traumatic brain injury (TBI). It describes the imaging features of acute head trauma, the pathophysiology of TBI, and the application of advanced imaging technology to brain-injured patients. Key Features: Covers acute as well as chronic traumatic brain injury Written in an easily accessible format, with pearls and summary boxes at the end of each chapter Includes state-of-the-art imaging techniques, including the multiplanar format, the utility of multiplanar reformats, perfusion imaging, susceptibility weighted imaging, and advanced MRI techniques Contains over 250 high-quality images This book will serve as a practical reference for practicing radiologists as well as radiology residents and fellows, neurosurgeons, trauma surgeons, and emergency physicians.
Author: Scott H. Faro
Publisher: Springer Science & Business Media
ISBN: 1441903453
Category : Medical
Languages : en
Pages : 1015
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Book Description
Functional Neuroradiology: Principles and Clinical Applications, is a follow-up to Faro and Mohamed’s groundbreaking work, Functional (BOLD)MRI: Basic Principles and Clinical Applications. This new 49 chapter textbook is comprehensive and offers a complete introduction to the state-of-the-art functional imaging in Neuroradiology, including the physical principles and clinical applications of Diffusion, Perfusion, Permeability, MR spectroscopy, Positron Emission Tomography, BOLD fMRI and Diffusion Tensor Imaging. With chapters written by internationally distinguished neuroradiologists, neurologists, psychiatrists, cognitive neuroscientists, and physicists, Functional Neuroradiology is divided into 9 major sections, including: Physical principles of all key functional techniques, Lesion characterization using Diffusion, Perfusion, Permeability, MR spectroscopy, and Positron Emission Tomography, an overview of BOLD fMRI physical principles and key concepts, including scanning methodologies, experimental research design, data analysis, and functional connectivity, Eloquent Cortex and White matter localization using BOLD fMRI and Diffusion Tensor Imaging, Clinical applications of BOLD fMRI in Neurosurgery, Neurology, Psychiatry, Neuropsychology, and Neuropharmacology, Multi-modality functional Neuroradiology, Beyond Proton Imaging, Functional spine and CSF imaging, a full-color Neuroanatomical Brain atlas of eloquent cortex and key white matter tracts and BOLD fMRI paradigms. By offering readers a complete overview of functional imaging modalities and techniques currently used in patient diagnosis and management, as well as emerging technology, Functional Neuroradiology is a vital information source for physicians and cognitive neuroscientists involved in daily practice and research.
Author: Carolyn A. Staton
Publisher: John Wiley & Sons
ISBN: 047002934X
Category : Medical
Languages : en
Pages : 410
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Book Description
Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.
Author: Vasken Dilsizian
Publisher: John Wiley & Sons
ISBN: 1444347969
Category : Medical
Languages : en
Pages : 476
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Book Description
This careful revision keeps pace with developments in the field, with new chapters on PET Metabolism, CT and MRI in the Emergency Department, Image-Guided Electrophysiology Mapping and Ablation, and Identification of Vulnerable Atherosclerotic Plaque by Radionuclide and CT techniques, plus the introduction of new contributors Udo Hoffman and Stephan Achenbach. Praised in its previous edition as a concise source of essential information, this new edition presents the most recent information in an accessible format and serves as an excellent reference source for all cardiologists, radiologists and nuclear medicine physicians.
