INSIGHT in Risk Factors and Treatment of Inhibitors in Nonsevere Hemophilia A PDF Download
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Author: Alice Sophie van Velzen
Publisher:
ISBN: 9789491602610
Category :
Languages : en
Pages : 0
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Book Description
Author: Alice Sophie van Velzen
Publisher:
ISBN: 9789491602610
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
Author: Alice Sophie Velzen
Publisher:
ISBN:
Category :
Languages : en
Pages : 287
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Book Description
Hemophilia A is an inherited X-linked bleeding disorder that occurs in male offspring of carrier females. In these individuals a mutation in the F8 gene, located on the X-chromosome, causes a deficiency of the factor VIII protein, clotting factor VIII. The worldwide prevalence of hemophilia is 1 in 5000 live male births, with one-third of the patients affected by severe hemophilia A and two-thirds of the patients have nonsevere disease. In patients with hemophilia A there is an impaired hemostasis due to a reduction of their factor VIII plasma level. This is associated with clinical symptoms of spontaneous bleeds in joints and muscles. An extremely severe and challenging complication of treatment with factor VIII concentrates in hemophilia A patients is the development of anti-factor VIII antibodies that inhibit (neutralize) the factor VIII activity, also referred to as inhibitors. This complication occurs in 25-30% of the severe hemophilia patients. Inhibitors seem to occur less frequently in nonsevere hemophilia A patients, although studies on inhibitor incidence in this group of patients are scarce. When a nonsevere hemophilia A patient develops an inhibitor, the phenotype of the disease may change dramatically. Nonsevere haemophilia A patients would normally only experience incidental bleeding episodes, but after inhibitor development the bleeding phenotype may aggravate dramatically, especially if the inhibitor reduces the endogenous factor VIII plasma levels. This is associated with an increased morbidity and mortality. This thesis focuses on the risk factors and treatment of inhibitors in nonsevere hemophilia A.
Author: Christine A. Lee
Publisher: John Wiley & Sons
ISBN: 140514386X
Category : Medical
Languages : en
Pages : 416
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Book Description
The only up-to-date definitive reference source onhemophilia This book is an invaluable resource that provides an overview ofall aspects of the care of patients with haemophilia. Covering how to assess both bleeding children and adults,Haemophilia A and B, molecular basis of the disease, the role offactors in coagulation, epidemiology, pharmacokinetics, andtreatment of inhibitors. There will also be a section onmusculoskeletal aspects of haemophilia as well as newerdevelopments such as gene therapy and rare bleedingdisorders. Textbook of Hemophilia is ideal for: Trainees and residents in hematology Hematologists in practice Specialists working in thrombosis and hemostasis as well astransfusion medicine Why Buy This Book? The only up-to-date definitive reference source onhemophilia Essential for all those managing hemophilia patients Detailed guidance on assessment, diagnosis, management andtreatment Advice for everyday clinical questions Edited by three of the world’s leading experts onhemophilia
Author: David Green
Publisher: Academic Press
ISBN: 0128129557
Category : Science
Languages : en
Pages : 286
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Book Description
Hemophilia and Von Willebrand Disease: Factor VIII and Von Willebrand Factor serves as a must-have reference on the important role these essential blood-clotting proteins play in research and clinical medicine. Clinicians and researchers face the daily challenge of staying current on the vast amounts of research that is now generated. The reference to Janus in the title refers to the two roles of the Factor VIII/Von Willebrand Factor Complex: initiation of coagulation and propagation of clot formation. The complex prevents bleeding in hemophilia and Von Willebrand disease but also augments arterial and venous thrombosis. Presents one source of information on Hemophilia and Von Willebrand Disease, as well as Factor VIII and Von Willebrand Factor, eliminating the search through hundreds of journal articles Combines the multi-disciplinary research that is generated from Factor VIII/Von Willebrand Factor – hematology, drug discovery, genetics, cell biology, and oncology Delves into unanswered questions and future directions of this important blood-clotting complex
Author: Christine A. Lee
Publisher: John Wiley & Sons
ISBN: 1118398246
Category : Medical
Languages : en
Pages : 573
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Book Description
The editors have included new authors and topics, and several chapters from second edition have been dropped. The overall organisation of the textbook has been changed in the light of changes of emphasis over the past 10 years. References have been restricted to create an overall succinct and comprehensive volume. A chapter on novel therapies in clinical trials or pre-clinical trials will be added at the time of going to press. The editors have consolidated the gene therapy section from three to two chapters, and retitled the Section, The Future of Haemophilia Therapy. The chapter on Old Age in Haemophilia has been extended to include more about survivorship with HCV/HIV and perioperative management (+/- anticoagulation in association with post-stent/cardiothoracic surgery following MI). Two areas that particularly needed reorganisation and rewriting were Inhibitors and Treatment to incorporate new products and future directions. Major new initiatives such as EUHASS have been incorporated. Furthermore, Ethical aspects of hemophilia care now merits a chapter on its own.
Author: Lucienne Chatenoud
Publisher: Frontiers Media SA
ISBN: 2832536255
Category : Medical
Languages : en
Pages : 193
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Book Description
Author: Craig S. Kitchens
Publisher: Elsevier Health Sciences
ISBN: 1455733296
Category : Medical
Languages : en
Pages : 843
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Book Description
A unique clinical focus makes Consultative Hemostasis and Thrombosis, 3rd Edition your go-to guide for quick, practical answers on managing the full range of bleeding and clotting disorders. Emphasizing real-world problems and solutions, Dr. Craig S. Kitchens, Dr. Barbara A. Konkle, and Dr. Craig M. Kessler provide all the clinical guidance you need to make optimal decisions on behalf of your patients and promote the best possible outcomes. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Efficiently look up concise descriptions of each condition, its associated symptoms, laboratory findings, diagnosis, differential diagnosis, and treatment. Get the latest information on hot topics such as Disseminated Intravascular Coagulation, Thrombophilia, Clinical and Laboratory Assessment and Management, Thrombotic -Thrombocytopenic Purpura, and Heparin-Induced Thrombocytopenia. Apply today’s newest therapies, including those that are quickly becoming standard in this fast-changing field. Meet the needs of specific patient groups with a new chapter on Bleeding and the Management of Hemorrhagic Disorders in Pregnancy and an extensively updated chapter on Thrombosis and Cancer. Zero in on key information with a new user-friendly design, and all-new full-color format, abundant laboratory protocols, and at-a-glance tables and charts throughout.
Author: Akbar Dorgalaleh
Publisher: Springer
ISBN: 3319767232
Category : Medical
Languages : en
Pages : 397
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Book Description
This book describes in detail the clinical presentation, diagnosis, and management of a wide range of congenital bleeding disorders. It will assist readers in overcoming the significant challenges involved in clinical and laboratory diagnosis and in providing effective clinical care that makes optimal use of new products, including recombinant factor concentrate. The coverage ranges from hemophilia A and B and von Willebrand disease to rare bleeding disorders such as congenital factor V, factor X, factor XI, and factor XIII deficiency and inherited platelet function disorders. The exceptional attention to rarer conditions is of particular importance given the considerable risk of overlooking them during diagnosis, with potential consequences for disease-related morbidity and mortality. The authors are acknowledged specialists in the field from across the world who have particular expertise in the disorder that they discuss. The book will be of value to hematologists, oncologists, pediatricians, laboratory specialists and technicians, general physicians, and trainees.
Author: Syed A. Abutalib
Publisher: Springer
ISBN: 331930352X
Category : Medical
Languages : en
Pages : 695
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Book Description
This book, in Q&A format, addresses a wide range of clinically relevant topics and issues in Nonmalignant Hematology, or “Benign Hematology,” with a view to offering a robust, engaging tool that will assist every hematologist and oncologist (pediatric and adult equally) in making decisions during day-to-day practice. The entire spectrum of the specialty is covered in more than 60 exceptional chapters written by acknowledged authorities in the field. The content is organized into well-designed broad sections on red cell disorders, platelet and coagulation disorders, coagulopathy in systemic diseases, thromboembolic disease and its management (including surgical), immune system and related disorders, hemostasis and thrombosis during pregnancy and in the newborn and elderly, and Transfusion Medicine. A key aspect of the book is the opportunity it affords expert physicians to express well-reasoned opinions regarding complex issues in Nonmalignant Hematology. Readers will find that it provides a practical and immediately applicable compendium of answers to often complex and vexing questions. It will appeal to residents, fellows, house officers and more experienced practitioners around the globe.
Author: Kathleen P. Pratt
Publisher: Frontiers Media SA
ISBN: 288966564X
Category : Medical
Languages : en
Pages : 250
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Book Description
The article processing charges (APCs) for some articles in this collection were partly financed by the Henry M. Jackson Foundation for the Advancement of Military Medicine, Maryland, USA (HJF), with funds which were originally granted by Grifols S.A, Barcelona, Spain (Grifols). Neither HJF nor Grifols influenced the content of any article in this collection.
