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Author: Parmis Blomgran
Publisher: Linköping University Electronic Press
ISBN: 917685471X
Category :
Languages : en
Pages : 59
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Book Description
Tendons heal through three different overlapping phases; the inflammatory, proliferative and remodeling phase. Many studies have investigated what factors influence healing of tendons. However, little was known about inflammation and the immune cells present during Achilles tendon healing by the time this thesis started. We developed a flow cytometry method for our rat model of tendon healing, which enabled us to study different leukocyte subpopulations during Achilles tendon healing. The general aim of this thesis was to understand more about inflammation and the immune cell populations present during tendon healing and how the immune cell composition changes during normal tendon healing. Moreover, we investigated how different factors that are known to influence tendon healing affected the composition of the immune cell population. First, we described the immune cells during the time course of tendon healing focusing on different subpopulations of macrophages and T cells. Then, we studied how these cells were influenced by reduced mechanical loading. Mechanical loading prolonged the presence of M1 macrophages and delayed the switch to regulatory T cells and M2 macrophages compared to reduced mechanical loading. Next, the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on the leukocyte composition revealed that, even though NSAIDs influence the mechanical properties of healing tendon, this effect was not mediated via changes in the leukocyte sub-populations during early and mid-time tendon healing. Further, the effect of corticosteroids during the inflammatory and remodeling phases of tendon healing was an improved healing of tendons and a reduction of CD8a T cells when corticosteroid was administered after the inflammatory phase. Lastly, we investigated if impairment of tendon healing by NSAIDs was related to mechanotransduction or microdamage during mechanical loading and showed that NSAIDs impair tendon healing by reducing the response to microdamage. In conclusion, these studies show that inflammation plays an important role during Achilles tendon healing, and factors that influence healing can also alter the presence or polarization of immune cell populations.
Author: Parmis Blomgran
Publisher: Linköping University Electronic Press
ISBN: 917685471X
Category :
Languages : en
Pages : 59
Get Book Here
Book Description
Tendons heal through three different overlapping phases; the inflammatory, proliferative and remodeling phase. Many studies have investigated what factors influence healing of tendons. However, little was known about inflammation and the immune cells present during Achilles tendon healing by the time this thesis started. We developed a flow cytometry method for our rat model of tendon healing, which enabled us to study different leukocyte subpopulations during Achilles tendon healing. The general aim of this thesis was to understand more about inflammation and the immune cell populations present during tendon healing and how the immune cell composition changes during normal tendon healing. Moreover, we investigated how different factors that are known to influence tendon healing affected the composition of the immune cell population. First, we described the immune cells during the time course of tendon healing focusing on different subpopulations of macrophages and T cells. Then, we studied how these cells were influenced by reduced mechanical loading. Mechanical loading prolonged the presence of M1 macrophages and delayed the switch to regulatory T cells and M2 macrophages compared to reduced mechanical loading. Next, the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on the leukocyte composition revealed that, even though NSAIDs influence the mechanical properties of healing tendon, this effect was not mediated via changes in the leukocyte sub-populations during early and mid-time tendon healing. Further, the effect of corticosteroids during the inflammatory and remodeling phases of tendon healing was an improved healing of tendons and a reduction of CD8a T cells when corticosteroid was administered after the inflammatory phase. Lastly, we investigated if impairment of tendon healing by NSAIDs was related to mechanotransduction or microdamage during mechanical loading and showed that NSAIDs impair tendon healing by reducing the response to microdamage. In conclusion, these studies show that inflammation plays an important role during Achilles tendon healing, and factors that influence healing can also alter the presence or polarization of immune cell populations.
Author: Manuela E. Gomes
Publisher: Academic Press
ISBN: 0128016000
Category : Science
Languages : en
Pages : 471
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Book Description
Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes is the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies. Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices. Contributions from scientists, clinicians, and engineers who are the leading figures in their respective fields present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field. - Provides an overview of tendon biology, disease, and tissue engineering approaches - Presents modern, alternative approaches to developing functional tissue solutions discussed - Includes valuable information for those interested in tissue engineering, tissue regeneration, tissue physiology, and regenerative medicine - Explores physiology, pathology, and surgical reconstruction, building a natural progression that enhances tendon regeneration practices - Covers recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field
Author: Terry S. Saxby
Publisher:
ISBN: 9781416050711
Category : Foot
Languages : en
Pages : 0
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Book Description
Tendon problems are a common cause of foot and ankle pathology. In the past decade there has been significant advances in the management of these problems. This has been achieved not only by an improvement of surgical techniques but also through a better understanding of tendon injury and healing. In this issue we will review the recent advances in the diagnosis and treatment of common tendon problems beginning with a review of tendon healing. This issue will provide the reader with an excellent review of all that is new on this topic.
Author: Paul W. Ackermann
Publisher: Springer
ISBN: 3319339435
Category : Medical
Languages : en
Pages : 299
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Book Description
This book will be of considerable interest to students, practitioners (Doctors, Physiotherapists, and other health care professionals), and researchers who deal with the complex structure of tendons and the need to effectively address tendon disorders. The book is divided into three sections: (1) Basic Biology and Biochemical Markers; (2) Metabolic Disorders; and (3) Novel Therapies. The first section, devoted to the basic biology of tendons, is aimed at those individuals who want to gain basic information on tendons and the subsection on biochemical markers is chiefly aimed at researchers who are developing new studies within this field. The section on metabolic disorders is mainly directed at practitioners who desire to know how metabolic disorders can affect tendons in order to optimize treatment for their patients. Finally, the section on novel therapies is focused on some new treatment options within this field, and discussions regarding how management of tendon disorders needs to incorporate perspectives on current understanding of tendon metabolism.
Author: Alberto Gobbi
Publisher: Springer
ISBN: 3662541815
Category : Medical
Languages : en
Pages : 677
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Book Description
This book introduces the exciting field of orthobiology, which will usher in a new array of therapeutic approaches that stimulate the body’s natural resources to regenerate musculoskeletal tissues damaged by trauma or disease. The book addresses a range of key topics and discusses emerging approaches that promise to offer effective alternatives to traditional treatments for injuries to bone, cartilage, muscles, ligaments, and tendons. It explains in detail how a variety of innovative products, including biomaterials, growth factors, and autogenous cells, together provide the basis for the regeneration of these musculoskeletal structures and how recent scientific progress has created unique opportunities to address pathological situations that until recently have been treated with unsatisfactory results. The authors are experts from across the world who come together to provide a truly global overview. The book is published in collaboration with ISAKOS. It will be invaluable for all with an interest in this area of medicine, which has already attained huge popularity in Orthopaedics and Sports Medicine and has also attracted the attention of the lay public.
Author: Savio L-Y. Woo
Publisher: John Wiley & Sons
ISBN: 0470757973
Category : Medical
Languages : en
Pages : 248
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Book Description
This concise volume in the Encyclopaedia of Sports Medicine series, published under the auspices of the International Olympic Committee, provides a dependable source of current knowledge available on tendinopathy and covers both the basic science and clinical aspects of the subject. Despite its high incidence, the precise etiopathogenesis and effective treatment of tendinopathy remain elusive. Tendinopathy in Athletes draws on the expertise of an international and prolific collection of contributors, both clinicians and scientists, who provide new insights into this specialized area. This book: provides a comprehensive resource for both clinicians and researchers with information organized logically, with an easy-to-follow progression from the basic scientific findings to clinical applications discusses the full range of treatment modalities, including new molecular and biological approaches, plus surgical and alternative approaches to tendinopath contains “What We Need to Know” sections that suggest future areas of research for young investigators. As tendinopathy remains one of the most common injuries encountered, both in sports and at the workplace, this essential volume is sure to be a source of frequent consultation.
Author: Gian Luigi Canata
Publisher: Springer
ISBN: 366254184X
Category : Medical
Languages : en
Pages : 440
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Book Description
This book explores in a comprehensive manner the causes and symptoms of muscle and tendon pathologies, the available diagnostic procedures, and current treatment approaches. Specific aspects of the anatomy, biomechanics, and function of muscles and tendons are analyzed, and detailed guidance is provided on the most innovative methods – both conservative and surgical – for ensuring that the athlete can make a safe and quick return to sporting activity. Optimal care of tendon and muscle injuries in sportspeople requires effective cooperation of sports scientists and medical practitioners to identify the best ways of preserving muscle and tendon structures and to develop new strategies for their rehabilitation and regeneration. Muscle and Tendon Injuries is an excellent multidisciplinary reference written by the leading experts in the field and published in collaboration with ISAKOS. It will appeal to all specialists in sports medicine and sports traumatology who are seeking a state of the art update on the management of muscle and tendon disorders.
Author: Heinz Redl
Publisher: Springer
ISBN: 9783319088303
Category : Technology & Engineering
Languages : en
Pages : 0
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Book Description
This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.
Author: Mahmut Nedim Doral
Publisher: Springer Nature
ISBN: 3642365698
Category : Medical
Languages : en
Pages : 3295
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Book Description
Sports Injuries: Prevention, Diagnosis, Treatment and Rehabilitation covers the whole field of sports injuries and is an up-to-date guide for the diagnosis and treatment of the full range of sports injuries. The work pays detailed attention to biomechanics and injury prevention, examines the emerging treatment role of current strategies and evaluates sports injuries of each part of musculoskeletal system. In addition, pediatric sports injuries, extreme sports injuries, the role of physiotherapy, and future developments are extensively discussed. All those who are involved in the care of patients with sports injuries will find this textbook to be an invaluable, comprehensive, and up-to-date reference.
Author: Steven D. Waldman
Publisher: Elsevier Health Sciences
ISBN: 0323640788
Category : Medical
Languages : en
Pages : 491
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Book Description
Covering the many relatively uncommon pain conditions that are often misdiagnosed, this one-of-a-kind visual resource clearly presents the extensive knowledge and experience of world-renowned pain expert Steven D. Waldman, MD, JD. Atlas of Uncommon Pain Syndromes, 4th Edition, first and foremost helps you make a correct diagnosis – a critical step in managing patients in chronic pain. Hundreds of high-quality illustrations, as well as x-rays, ultrasound, CTs, and MRIs, help you confirm your diagnoses with confidence. - Offers head-to-toe coverage – 135 conditions in all – providing concise, easy-to-read chapters for each condition. Dr. Waldman's practical guidance is designed to help you make the correct diagnosis of uncommon pain syndromes, even the signs and symptoms don't quite fit. - Explains each pain syndrome using a consistent, easy-to-follow format: an ICD-10 CM code for billing purposes, followed by a brief description of the signs and symptoms, laboratory and radiographic testing, differential diagnosis, available treatment options, and clinical pearls. - Features updated chapters throughout, as well as 12 new chapters covering Hemicrania Continua, Acute Calcific Prevertebral Tendinitis, Sternohyoid Syndrome Snapping Scapula Syndrome, Erythromelagia, Foix-Alajouanine Syndrome, Lumbar Paraspinous Muscle Compartment Syndrome, Clunealgia, Nutcracker Syndrome, Paroxysmal Extreme Pain Disorder, Iliopsoas Tendon Rupture, and Snapping Pes Anserinus Syndrome - Provides practitioners and trainees in pain medicine, anesthesiology, neurology, psychiatry, physical medicine and rehabilitation, primary care, and more with a firm foundation in the diagnosis of uncommon pain in daily practice.
