Human Developmental Neurotoxicology PDF Download
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Author: David C. Bellinger
Publisher: CRC Press
ISBN: 1040164005
Category : Medical
Languages : en
Pages : 568
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Book Description
This reference describes the most recent developments in the design, execution, and interpretation of human developmental neurotoxicology studies. Assessing critical issues and controversies in the field, this guide focuses on dose-response/effect relationships and explores challenges in the measurement of exposure to different types of chemicals,
Author: David C. Bellinger
Publisher: CRC Press
ISBN: 1040164005
Category : Medical
Languages : en
Pages : 568
Get Book Here
Book Description
This reference describes the most recent developments in the design, execution, and interpretation of human developmental neurotoxicology studies. Assessing critical issues and controversies in the field, this guide focuses on dose-response/effect relationships and explores challenges in the measurement of exposure to different types of chemicals,
Author: William Slikker Jr.
Publisher: Academic Press
ISBN: 0128093943
Category : Science
Languages : en
Pages : 618
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Book Description
Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience. - Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition - Contains new chapters that focus on subjects recent to the field - Includes well-illustrated material, with diagrams, charts, and tables - Contains compelling case studies and chapters written by world experts
Author: David C. Bellinger
Publisher: CRC Press
ISBN: 9780824729882
Category : Medical
Languages : en
Pages : 0
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Book Description
This reference describes the most recent developments in the design, execution, and interpretation of human developmental neurotoxicology studies. Assessing critical issues and controversies in the field, this guide focuses on dose-response/effect relationships and explores challenges in the measurement of exposure to different types of chemicals, including selected metals, organic pollutants, pesticides, and recreational and therapeutic drugs.
Author: Cynthia A. Riccio
Publisher: Springer
ISBN: 331932358X
Category : Psychology
Languages : en
Pages : 205
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Book Description
This book focuses on children and the impact of neurotoxins on the developing brain to guide the practice of psychologists working with children in clinical and school settings. Each chapter covers a distinct neurotoxin or group of neurotoxins, with particular emphasis on the impact of the neurotoxin exposure on the developing brain and long-term cognitive and psychosocial outcomes. This is more complex than studying neurotoxins with adults because of the rapid development occurring in the child's brain. Further, children are more susceptible than adults to the effects of neurotoxins due to their developmental status. Many of the effects discussed in this volume occur in utero, thus setting the stage for an altered developmental trajectory.
Author: G Jean Harry
Publisher: CRC Press
ISBN: 9781439805503
Category : Medical
Languages : en
Pages : 208
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Book Description
Developmental Neurotoxicology addresses a number of basic principles underlying the vulnerability of the developing nervous system to environmental toxicant exposure. Evidence of functional alterations, induced at levels of chemical exposure that fail to produce structural teratological alterations, indicates that the evaluation of the functional capacity of exposed animals may indeed offer a sensitive evaluation of developmental toxicity. The contributing authors discuss the basic principles of development in structure and functional components and present information covering various methodological approaches, as well as evidence for the value of examining the developing nervous system for environmentally induced perturbations. The final chapter covers how this type of data is used to evaluate human risk potential.
Author:
Publisher:
ISBN:
Category : Environmental health
Languages : en
Pages : 1576
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Book Description
Author:
Publisher:
ISBN:
Category : Asthma
Languages : en
Pages : 958
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Book Description
Author: Louis W. Chang
Publisher: Elsevier
ISBN: 0080537472
Category : Science
Languages : en
Pages : 875
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Book Description
Neurotoxicology: Approaches and Methods provides a unique and comprehensive presentation of the current concepts and state-of-the-art methods for the assessment of neurotoxicity. The book analyzes various techniques available and discusses their strengths and weaknesses. This volume will serve as an excellent desk companion and laboratory guide for all investigators, researchers, clinicians, and students interested in neurotoxicology. The internationally knowngroup of editors divide the book into seven sections: Neuromorphological and Neuropathological Approaches; Neurophysiological Approaches; Neurobehavioral Toxicology; Neurochemical and Biomolecular Approaches; In-Vitro Models; Clinical Neurotoxicology; and Risk Assessment of Neurotoxicity. Each section yields the most up-to-date information by experts in their fields. Meticulously organized and edited, Neurotoxicology: Approaches and Methods is the most authoritative and well-planned neurotoxicology book on the market. - Discusses neurobehavioral testing methods for assessment of neural dysfunctions - Explains state-of-the-art diagnostic methods, such as clinico-neuropsychological and neurophysiological methods, for patients confronted by neurotoxic problems - Discusses In Vitro methods, including aggregating brain cell methods, organotypic cultures, and the use of human neuronal cell lines for the assessment of neurotoxicity - Presents step-by-step procedures for many methods - Provides state-of-the-art neuromorphological and biomolecular methods and approaches for neurotoxicity investigation
Author: Edward J. Massaro
Publisher: Springer Science & Business Media
ISBN: 1592591655
Category : Medical
Languages : en
Pages : 599
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Book Description
N eurotoxicology is a broad and burgeoning field of research. Its growth in recent years can be related, in part, to increased interest in and concern with the fact that a growing number of anthropogenic agents with neurotoxic potential, including pesticides, 1ead, mercury, and the polytypic byproducts of combustion and industrial production, continue to be spewed into and accumulate in the environment. In addition, there is great interest in natural products, including toxins, as sources of therapeutic agents. Indeed, it is well known that many natural toxins ofbroadly differing structure, produced or accumulated for predatory or defensive purposes, and toxic agents, accumulated incidentalIy by numerous species, function to perturb nervous tissue. Components of some of these toxins have been shown to be useful therapeutic agents and/or research reagents. Unfor of some neurotoxicants of anthropogenic ori tunately, the environmental accumulation gin, expecialIy pesticides and metals, has resulted in incidents ofhuman poisoning, some of epidemic proportion, and high levels of morbidity and mortality. Furthermore, an increasing incidence of neurobehavioral disorders, some with baffling symptoms, is confronting clinicians. It is not clear whether this is merely the re suit of increased vigi lance and/or improved diagnostics or a consequence of improved health care. In any case, the role of exposure to environmental and occupational neurotoxicants in the etiology of these phenomena, as well as neurodegenerative diseases, is coming under increasing scrutiny and investigation.
Author: Harold Zeliger
Publisher: William Andrew
ISBN: 1437734642
Category : Medical
Languages : en
Pages : 575
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Book Description
In this important reference work, Zeliger catalogs the known effects of chemical mixtures on the human body and also proposes a framework for understanding and predicting their actions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. The author's focus is on illnesses that ensue following exposures to mixtures of chemicals that cannot be attributed to any one component of the mixture. In the first part the mechanisms of chemical absorption at a molecular and macromolecular level are explained, as well as the body's methods of defending itself against xenobiotic intrusion. Part II examines the sources of the chemicals discusssed, looking at air and water pollution, food additives, pharmaceuticals, etc. Part III, which includes numerous case studies, examines specific effects of particular mixtures on particular body systems and organs and presents a theoretical framework for predicting what the effects of uncharacterized mixtures might be. Part IV covers regulatory requirements and the need to adjust recommended exposure levels for products containing mixtures. It also contains recommendations on how to limit exposure to mixtures in the products we use and on how to limit release of mixtures into the environment. Providing brief summaries of each mixture and its effects, Zeliger provides a comprehensive reference, a jumping off point for professionals (with extensive chapter bibliographies) and an introduction to the topic for those studying traditional toxicology. Addressing many inadequately understood illnesses and conditions such as asthma, infertility and cancer, it will also be of interest to health professionals, environmental scientists and lawyers. - Presents a theoretical framework for predicting the effects of chemical mixtures for which no specific data exists (this predictive aspect is important due to the vast number of different potential chemical combinations – far too many to comprehensively catalog) - A quick and convenient source of hard to come by data on the rapidly developing field of chemical mixtures, for groups including chemists and engineers, toxicologists, health professionals and environmental scientists - New and updated material comprises over 30% of this timely new edition, which includes the latest research data alongside an expanded introduction to the science and art of predicting the toxicological properties of chemical mixtures
