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Author: Carolyn A. Staton
Publisher: John Wiley & Sons
ISBN: 047002934X
Category : Medical
Languages : en
Pages : 410
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Book Description
Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.
Author: Carolyn A. Staton
Publisher: John Wiley & Sons
ISBN: 047002934X
Category : Medical
Languages : en
Pages : 410
Get Book Here
Book Description
Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.
Author: Jakub Kupecki
Publisher: Springer
ISBN: 9783030092757
Category : Technology & Engineering
Languages : en
Pages : 0
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Book Description
The book summarizes the current state of the solid oxide fuel cell (SOFC) technology in power generation applications. It describes the single cells, SOFC stacks, micro-combined heat and power systems, large-scale stationary power generators and polygeneration units. The principles of modeling, simulation and controls of power systems with solid oxide fuel cells are presented and discussed. Authors provide theoretical background of the technology followed by the essential insights into the integrated power systems. Selected aspects of the design, construction and operation of power units in range from single kilowatts to hundreds of kilowatts are presented. Finally, the book reports the selected studies on prototype systems which have been constructed in Europe. The book discusses the theoretical and practical aspects of operation of power generators with solid oxide fuel cells including fabrication of cells, design of stacks, system modeling, simulation of stationary and non-stationary operation of systems, fuel preparation and controls.
Author: Elvis Fosso-Kankeu
Publisher: John Wiley & Sons
ISBN: 1119577055
Category : Science
Languages : en
Pages : 382
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Book Description
Presents recent challenges related to new forms of pollution from industries and discusses adequate state-of-the-art technologies capable to remediate such forms of pollution. Over the past few decades the boom in the industrial sector has contributed to the release in the environment of pollutants that have no regulatory status and which may have significant impact on the health of humans and animals. These pollutants also referred to as "emerging pollutants", are mostly aromatic compounds which derive from excretion of pharmaceutical, industrial effluents and municipal discharge. It is recurrent these days to find water treatment plants which no longer produce water that fits the purpose of domestic consumption based on newly established guidelines. This situation has prompted water authorities and researchers to develop tools for proper prediction and control of the dispersion of pollutants in the environment to ensure that appropriate measures are taken to prevent the occurrence of outbreaks due to sudden load of these pollutants in the water system. The chapters in this book cover a wide range of nano and bio-based techniques that have been designed for the real time detection of emerging contaminants in environmental water sources, geochemical models that are continuously improved for the prediction of inorganic contaminants migration from the mine solid wastes into ground and surface waters. Remediation strategies are also discussed and include effective techniques based on nanotechnology, advanced membrane filtration, oxidative and bio-degradation processes using various types of nanocatalysts, biocatalysts or supporting polymer matrices which are under advanced investigations for their implementation at large scale for the removal of recalcitrant pollutants from polluted water. Nano and Bio-Based Technologies for Wastewater Treatment: Prediction and Control Tools for the Dispersion of Pollutants in the Environment is divided is two sections. The first section covers the occurrence of emerging pollutants in environmental water while the second section covers state-of-the-art research on the removal of emerging pollutants from water using sustainable technologies. A total of 13 chapters addressing various topics related to the two sections are essentially based on recent developments in the respective field which could have a significant impact on the enhancement of the performance of wastewater treatment plants around the world, and especially in developing countries where access to clean and safe water remains a daily challenge.
Author: Günter P. Merker
Publisher: Springer Science & Business Media
ISBN: 3642140947
Category : Technology & Engineering
Languages : en
Pages : 660
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Book Description
Combustion Engines Development nowadays is based on simulation, not only of the transient reaction of vehicles or of the complete driveshaft, but also of the highly unsteady processes in the carburation process and the combustion chamber of an engine. Different physical and chemical approaches are described to show the potentials and limits of the models used for simulation.
Author: Nejat Ince
Publisher: Springer Science & Business Media
ISBN: 0387739084
Category : Computers
Languages : en
Pages : 470
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Book Description
This book contains a selection of papers presented at a symposium organized under the aegis of COST Telecommunications Action 285. COST (European Cooperation in the field of Scientific and Technical Research) is a framework for scientific and technical cooperation, allowing the coordination of national research on a European level. Action 285 sought to enhance existing tools and develop new modeling and simulation tools.
Author: Agata Godula-Jopek
Publisher: John Wiley & Sons
ISBN: 3527649948
Category : Science
Languages : en
Pages : 220
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Book Description
An exploration of current and possible future hydrogen storage technologies, written from an industrial perspective. The book describes the fundamentals, taking into consideration environmental, economic and safety aspects, as well as presenting infrastructure requirements, with a special focus on hydrogen applications in production, transportation, military, stationary and mobile storage. A comparison of the different storage technologies is also included, ranging from storage of pure hydrogen in different states, via chemical storage right up to new materials already under development. Throughout, emphasis is placed on those technologies with the potential for commercialization.
Author: Maurice E F Bloch
Publisher: Routledge
ISBN: 0429968531
Category : Social Science
Languages : en
Pages : 216
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Book Description
“Maurice Bloch is so ferociously smart that one can always enjoy tangling with his ideas, even when—perhaps especially when—one doesn’t agree with him. This is an important and provocative book.” —Sherry Ortner Columbia University These essays by one of anthropology’s most original theorists consider such fundamental questions as: Is cognition language-based? How reliable a guide to memory are people’s narratives about themselves? What connects the “social recalling” studied by anthropologists to the “autobiographical memory” studied by psychologists? Now gathered in accessible form for the first time and drawing frequently upon the author’s fieldwork among the Zafimaniry of Madagascar for ethnographic examples, the twelve closely linked essays of How We Think They Think pose provocative challenges not only to conventional cognitive models but to the basic assumptions that underlie much of ethnography. This book will be read with interest by those who study culture and cognition, ethnographic theory and practice, and the peoples and cultures of Africa.
Author: V. Barsukov
Publisher: Springer Science & Business Media
ISBN: 9780792339489
Category : Science
Languages : en
Pages : 564
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Book Description
Electricity is the most important secondary energy source, the present production rate, mainly from thermal electric power stations, being of the order of 1.3 TW. However, the total capacity of primary and rechargeable batteries currently in use is the same as the output of the world's power stations. But present battery systems will not meet future needs for the economical storage of large amounts of electrical energy for vehicles, public transport, road levelling, solar energy utilisation, civil video and audio, terrestrial and space communications, etc. Current accumulators based on aqueous acid or alkali systems do not have sufficient output and, moreover, the materials employed (Pb, Cd, Ni) are environmental pollutants that require safe recycling. Further, stocks of these strategic metals are being rapidly depleted. This book discusses actual field results with novel systems, such as rechargeable lithium batteries, zinc/air cells, metal-free accumulators, graphite/carbon devices and others, including fuel cells. The book stresses that a universal electrochemical system is not feasible: the choice of any system must depend on the concrete field of application and must be taken in consideration of a large number of technical, economic and environmental circumstances.
Author: Julian Weber
Publisher: Springer Science & Business Media
ISBN: 3642012531
Category : Technology & Engineering
Languages : en
Pages : 321
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Book Description
The global crisis the automotive industry has slipped into over the second half of 2008 has set a fierce spotlight not only on which cars are the right ones to bring to the market but also on how these cars are developed. Be it OEMs developing new models, suppliers integerating themselves deeper into the development processes of different OEMs, analysts estimating economical risks and opportunities of automotive investments, or even governments creating and evaluating scenarios for financial aid for suffering automotive companies: At the end of the day, it is absolutely indispensable to comprehensively understand the processes of auto- tive development – the core subject of this book. Let’s face it: More than a century after Carl Benz, Wilhelm Maybach and Gottlieb Daimler developed and produced their first motor vehicles, the overall concept of passenger cars has not changed much. Even though components have been considerably optimized since then, motor cars in the 21st century are still driven by combustion engines that transmit their propulsive power to the road s- face via gearboxes, transmission shafts and wheels, which together with spri- damper units allow driving stability and ride comfort. Vehicles are still navigated by means of a steering wheel that turns the front wheels, and the required control elements are still located on a dashboard in front of the driver who operates the car sitting in a seat.
Author: Rolf Heister
Publisher: Springer Science & Business Media
ISBN: 3642742440
Category : Medical
Languages : en
Pages : 451
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Book Description
Not everyone is a friend of the manifold abbreviations that have by now beCome a part of the scientific language of medicine. In order to avoid misunderstanding these abbreviations, it is wise to refer to a reliable dic tionary, such as this one prepared by Heister. The abbreviation ED means, for instance, effective dose to the pharmacologist. However, it might also stand for emetic dose. Radiologists use the same abbreviation for erythema dose, and ED could also mean ethyl dichlorarsine. A com mon meaning of ECU is European currency unit, a meaning that might not be very often in scientific medical publications. ECU, however, also means environmental control unit or European Chiropractic Union. Hopefully, those making inventions and discoveries will make use of Heister's dictionary before creating new abbreviations when preparing manuscripts for scientific publications. It is a very worthwhile goal not to use the same abbreviation for several different terms, especially if it is already widely accepted to mean only one of them. It may be impossible, however, to achieve this goal in different scientific disciplines. Therefore, although it is wise for the abbreviations used in a publication to be defined, it is also very helpful for readers and writers to use a dictionary such as this one. The author deserves our warmest thanks since we know that compiling such a comprehensive dictionary is based upon incredibly hard effort.
