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Author: Ernst Petzinger
Publisher: Springer Science & Business Media
ISBN: 3642742475
Category : Science
Languages : en
Pages : 440
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Book Description
Hepatic cells are involved in the metabolization and elimination of a variety of endogenous and exogenous substances. They mediate the uptake, processing and subsequent secretion of biliary compounds, such as various drugs or hormones, and the passage of metabolites to be released into different blood compartments. To perform vectorial passages hepatocytes show a strong polarity with sites for endocytotic processes or specific carrier molecules, and a specified system of organelles for intracellular transport and sorting, metabolization and secretion of compounds. Several aspects, e.g. regulation, control and mechanisms of hepatic traffic are reported in detail - complemented by methodological approaches to analyse and monitor these processes.
Author: Ernst Petzinger
Publisher: Springer Science & Business Media
ISBN: 3642742475
Category : Science
Languages : en
Pages : 440
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Book Description
Hepatic cells are involved in the metabolization and elimination of a variety of endogenous and exogenous substances. They mediate the uptake, processing and subsequent secretion of biliary compounds, such as various drugs or hormones, and the passage of metabolites to be released into different blood compartments. To perform vectorial passages hepatocytes show a strong polarity with sites for endocytotic processes or specific carrier molecules, and a specified system of organelles for intracellular transport and sorting, metabolization and secretion of compounds. Several aspects, e.g. regulation, control and mechanisms of hepatic traffic are reported in detail - complemented by methodological approaches to analyse and monitor these processes.
Author: John A. Young
Publisher: Springer Science & Business Media
ISBN: 3642750338
Category : Medical
Languages : en
Pages : 375
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Book Description
This volume aims to give a comprehensive overview of the cellular mechanisms underlying the process of secretion in vertebrate, particularly mammalian, exocrine glands. The subject matter is divided into two sections. The first section deals with general aspects of secretion, including chapters on the roles of ion channels in secretion. Signal transduction is also covered, and several chapters deal with recently developed investigative techniques that offer promise as tools for the further investigation of exocrine secretory processes. The second section deals with secretion in a selection of exocrine organs: salivary glands, lacrimal glands, the pancreas, gastric mucosa, liver, epididymis, and vertebrate salt glands. A final chapter deals with cystic fibrosis, the common, fatal, inherited disease, which affects exocrine glands particularly severely.
Author: Kenneth L. Andus
Publisher: Springer Science & Business Media
ISBN: 1461528984
Category : Medical
Languages : en
Pages : 507
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Book Description
In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.
Author: Yurong Lai
Publisher: Woodhead Publishing
ISBN: 190881828X
Category : Science
Languages : en
Pages : 759
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Book Description
Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments. A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development Balanced coverage of molecular biology aspects and functional outcomes State of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity
Author: Ambikanandan Misra
Publisher: Elsevier
ISBN: 0123849659
Category : Science
Languages : en
Pages : 686
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Book Description
Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery. Covers a diverse array of topics from basic sciences to therapeutic applications of proteomics and genomics delivery Of interest to researchers in both academia and industry Highlights what’s currently known and where further research is needed
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309136997
Category : Medical
Languages : en
Pages : 338
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Book Description
In the early 1980s, two water-supply systems on the Marine Corps Base Camp Lejeune in North Carolina were found to be contaminated with the industrial solvents trichloroethylene (TCE) and perchloroethylene (PCE). The water systems were supplied by the Tarawa Terrace and Hadnot Point watertreatment plants, which served enlisted-family housing, barracks for unmarried service personnel, base administrative offices, schools, and recreational areas. The Hadnot Point water system also served the base hospital and an industrial area and supplied water to housing on the Holcomb Boulevard water system (full-time until 1972 and periodically thereafter). This book examines what is known about the contamination of the water supplies at Camp Lejeune and whether the contamination can be linked to any adverse health outcomes in former residents and workers at the base.
Author: Thomas E. Andreoli
Publisher: Springer Science & Business Media
ISBN: 1461320976
Category : Medical
Languages : en
Pages : 1062
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Book Description
The second edition of Physiology of Membrane Disorders represents an extensive revision and a considerable expansion of the first edition . Yet the purpose ofthe second edition is identical to that of its predecessor, namely, to provide a rational analysis of membrane transport processes in individual membranes, cells, tissues, and organs, which in tum serves as a frame of reference for rationalizing disorders in which derangements of membrane transport processes playa cardinal role in the clinical expression of disease. As in the first edition, this book is divided into a number of individual, but closely related, sections. Part V represents a new section where the problem of transport across epithelia is treated in some detail. Finally, Part VI, which analyzes clinical derangements, has been enlarged appreciably. THE EDITORS xi Preface to the First Edition The purpose of this book is to provide the reader with a rational frame of reference for assessing the pa thophysiology of those disorders in which derangements of membrane transport processes are a major factor responsible for the clinical manifestations of disease. In the present context, we use the term "membrane transport to refer to those molecular processes whose cardinal function, broadly speaking, is processes" in a catholic sense, the vectorial transfer of molecules-either individually or as ensembles-across biological interfaces, the latter including those interfaces which separate different intracellular compartments, the cellular and extracellular com partments, and secreted fluids-such as glomerular filtrate-and extracellular fluids.
Author: Erwin Kuntz
Publisher: Springer Science & Business Media
ISBN: 3540289771
Category : Medical
Languages : en
Pages : 902
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Book Description
Hepatology -- a systematic overview The 1st edition was sold out within one year and a reprint became necessary. The 2nd edition has been updated, revised and extended to include some 900 pages. Unique - 477 top-quality coloured figures containing clinical and immunological findings, laparoscopic and and histologic features as well as imaging procedures - all figures directly integrated in the respective text; this results in a new form of learning from "seeing" to "understanding" Attractive - 306 tables in colour - coloured highlighting of important principles and statements for better reading - well-structured and systematic approaches support the content - derived from clinical hepatology for practical use by specialists and in hospital Instructive - detailed presentation of morphology and its integration in liver disease - precise recommendations for therapy and summarized descriptions of special forms of treatment (inlcuding a separate chapter on "Therapy" Manual - about 7,000 references are listed in full; quotations of significant historical publications - first authors of therapy procedures, methods, medical techniques and invasive measures are given as far as possible - comprehensive subject index and register of abbreviations
Author: J. Gordon Betts
Publisher:
ISBN: 9781947172807
Category :
Languages : en
Pages : 0
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Book Description
Author: Frederick J. Suchy
Publisher: Cambridge University Press
ISBN: 1108911374
Category : Medical
Languages : en
Pages : 875
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Book Description
Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.
