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Author: Roy G. Smith
Publisher: Springer Science & Business Media
ISBN: 1617799025
Category : Medical
Languages : en
Pages : 296
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Book Description
Ghrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical in the control of food intake and energy balance. The ghrelin receptors are now known to have important physiological properties as modulators of growth hormone release, appetite, glucose homeostasis, metabolism, immune function, neurotransmitter activity, cognitive function and neurodegeneration. Bringing all of this information together in the first comprehensive text on the topic, the editors provide a state-of-the-art synthesis of the latest work in this area for physicians and physician-scientists. This volume addresses the unique property of ghrelin as a modulator of function. Such a property provides potential utility for safe intervention in a wide variety of disease states. Indeed as we learn more about the basic physiology of ghrelin, the potential for treating new disease targets emerge requiring validation in the clinic. Hence, there is a need to combine information from basic translational research on ghrelin with results of clinical investigations. Each chapter in this volume is authored by a leading investigator in the field. The introductory chapter sets the background for the book and provides a superb overview of the relevance of ghrelin to physiology, describing how the discovery of ghrelin has prompted us to completely rethink traditional physiology. The authors conclude their chapters by critically addressing the future translational aspects of ghrelin biology and outlining what key basic research and clinical questions remain to be addressed. An invaluable resource, Ghrelin in Health and Disease distinguishes itself as the first comprehensive title covering all of the molecular and clinical issues relating to ghrelin and advancing our clinical understanding of obesity, growth, and reproductive pathogenesis.
Author: Roy G. Smith
Publisher: Springer Science & Business Media
ISBN: 1617799025
Category : Medical
Languages : en
Pages : 296
Get Book
Book Description
Ghrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical in the control of food intake and energy balance. The ghrelin receptors are now known to have important physiological properties as modulators of growth hormone release, appetite, glucose homeostasis, metabolism, immune function, neurotransmitter activity, cognitive function and neurodegeneration. Bringing all of this information together in the first comprehensive text on the topic, the editors provide a state-of-the-art synthesis of the latest work in this area for physicians and physician-scientists. This volume addresses the unique property of ghrelin as a modulator of function. Such a property provides potential utility for safe intervention in a wide variety of disease states. Indeed as we learn more about the basic physiology of ghrelin, the potential for treating new disease targets emerge requiring validation in the clinic. Hence, there is a need to combine information from basic translational research on ghrelin with results of clinical investigations. Each chapter in this volume is authored by a leading investigator in the field. The introductory chapter sets the background for the book and provides a superb overview of the relevance of ghrelin to physiology, describing how the discovery of ghrelin has prompted us to completely rethink traditional physiology. The authors conclude their chapters by critically addressing the future translational aspects of ghrelin biology and outlining what key basic research and clinical questions remain to be addressed. An invaluable resource, Ghrelin in Health and Disease distinguishes itself as the first comprehensive title covering all of the molecular and clinical issues relating to ghrelin and advancing our clinical understanding of obesity, growth, and reproductive pathogenesis.
Author: Dennis Hertz
Publisher:
ISBN: 9781536168518
Category :
Languages : en
Pages : 125
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Book Description
Ghrelin is a 28-amino acid peptide mainly secreted by the stomach. To better understand the role of ghrelin signaling, Ghrelin: Function, Mechanism of Action and Role in Health and Disease first explores the regulation of age-associated adipose tissue inflammation. Following this, the authors discuss the influence of different variables on the response of short-term appetite regulation induced by exercise. External factors such as temperature and environment exert effects on hormonal responses, including hunger sensation and energy intake. The effects of gender differences and aging on psychological stress-dependent eating disorders are assessed, and the involvement of endogenous ghrelin, the serotonin 2c receptor and the estrogen alpha receptor is discussed. The penultimate chapter reviews the relationship between sleep and eating behavior, focusing in the influences of circadian changes on appetite related responses such as plasma concentration of ghrelin. The concluding study highlights the ghrelin system as a promising candidate for cardiovascular drug discovery, a new therapeutic approach for the treatment of endothelial impairment, and a possible contribution to the prevention of atherosclerosis.
Author: Stephen Robert Bloom
Publisher:
ISBN:
Category : Gastrointestinal hormones
Languages : en
Pages : 640
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Book Description
Author: A. Benso
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805599080
Category : Medical
Languages : en
Pages : 181
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Book Description
The ghrelin story started more than 30 years ago with the discovery of synthetic GH secretagogues. Only in 1999 was ghrelin‚ a natural GH-releasing peptide, discovered. Ghrelin, however, is much more than simply a natural GH secretagogue. In fact, this hormone is one of the most important factors known for regulating appetite and energy expenditure. Furthermore, ghrelin is the trigger for other neuroendocrine, metabolic and nonendocrine actions.This book, written by researchers who provided the major contributions to our current knowledge of this complex system, gives a comprehensive overview of the recent advances in ghrelin research. The hormone's influence on the cardiovascular, metabolic and gastroenteropancreatic system, hypothalamus-pituitary-adrenal axis, prolactin secretion, thyroid axis, gonadal axis as well as on behavior is discussed in detail. Furthermore, the clinical perspectives for ghrelin-derived therapeutic products are presented.Illustrating the tight inter-relationship between endocrinology, metabolism, cardiovascular disease and internal medicine, this book is essential reading for all scientists interested in appetite control, body weight and energy expenditure, as well as diabetes mellitus and neuroendocrinology.
Author: Ezio Ghigo
Publisher: Springer Science & Business Media
ISBN: 1402079710
Category : Medical
Languages : en
Pages : 259
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Book Description
Ghrelin is a 28-amino acid acylated peptide predominatntly produced by the stomach. Highlights the impact and function of the hormone ghrelin and provides insight to neuroendocrinologies and researchers interested in its molecular and clinical relevance.
Author: Roy G. Smith
Publisher: Springer Science & Business Media
ISBN: 1617799033
Category : Medical
Languages : en
Pages : 290
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Book Description
Ghrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical in the control of food intake and energy balance. The ghrelin receptors are now known to have important physiological properties as modulators of growth hormone release, appetite, glucose homeostasis, metabolism, immune function, neurotransmitter activity, cognitive function and neurodegeneration. Bringing all of this information together in the first comprehensive text on the topic, Ghrelin in Health and Disease provides a state-of-the-art synthesis of the latest work in this area for physicians and physician-scientists. This volume addresses the unique property of ghrelin as a modulator of function. Such a property provides potential utility for safe intervention in a wide variety of disease states. Indeed as we learn more about the basic physiology of ghrelin, the potential for treating new disease targets emerge requiring validation in the clinic. Each chapter in this volume is authored by a leading investigator in the field. The introductory chapter sets the background for the book and provides a superb overview of the relevance of ghrelin to physiology, describing how the discovery of ghrelin has prompted us to completely rethink traditional physiology. The authors conclude their chapters by critically addressing the future translational aspects of ghrelin biology and outlining what key basic research and clinical questions remain to be addressed. An invaluable resource, Ghrelin in Health and Disease distinguishes itself as the first comprehensive title covering all of the molecular and clinical issues relating to ghrelin and advancing our clinical understanding of obesity, growth, and reproductive pathogenesis.
Author: Debasis Bagchi
Publisher: Academic Press
ISBN: 9780080961729
Category : Medical
Languages : en
Pages : 536
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Book Description
Understanding the complex factors contributing to the growing childhood obesity epidemic is vital not only for the improved health of the world's future generations, but for the healthcare system. The impact of childhood obesity reaches beyond the individual family and into the public arenas of social systems and government policy and programs. Global Perspectives on Childhood Obesity explores these with an approach that considers the current state of childhood obesity around the world as well as future projections, the most highly cited factors contributing to childhood obesity, what it means for the future both for children and society, and suggestions for steps to address and potentially prevent childhood obesity. This book will cover the multi-faceted factors contributing to the rapidly growing childhood obesity epidemic The underlying causes and current status of rapidly growing obesity epidemic in children in the global scenario will be discussed The strategies for childhood obesity prevention and treatment such as physical activity and exercise, personalized nutrition plans and school and community involvement will be presented
Author: Abba Kastin
Publisher: Elsevier
ISBN: 0080463797
Category : Science
Languages : en
Pages : 1682
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Book Description
Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar. *Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.*Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.
Author: Egidio Del Fabbro
Publisher: Springer
ISBN: 1910315079
Category : Medical
Languages : en
Pages : 88
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Book Description
Cancer Cachexia is a concise, fully illustrated handbook written with the aim of increasing awareness of cancer cachexia and highlighting best practice diagnosis, treatment, and management options for this devastating disorder. This is another title in the ongoing Springer Healthcare Cancer Supportive Care Series.
Author: Yoshio Takei
Publisher: Academic Press
ISBN: 0128010673
Category : Science
Languages : en
Pages : 1156
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Book Description
Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research collates fundamental information about the structure and function of hormones from basic biology to clinical use. The handbook offers a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors and signalling pathways, and the biological activities they regulate. The evolution of hormones and gene families is also covered both in the text and in online ancillaries. Users will find simple and visual ways to learn key molecular information. Chapters and online ancillary resources integrate additional sections, providing a comparative molecular, functional, and evolutionary consideration. Provides the only single resource available with concise, yet informative descriptions of hormones in vertebrates, invertebrates, and plants Presents hormones in groups according to their origin, so that readers can easily understand their inter-relation Includes comparative information on the structures and functions of hormones enabling readers to understand both general and specific actions in and across species Ancillary website hosts additional information, including sequence data, comparative data, figures, and tables
