Genetic Analysis of Odor-guided Behavior in Drosophila Melanogaster PDF Download
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Author: Indrani Ganguly
Publisher:
ISBN:
Category :
Languages : en
Pages : 157
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Keywords: Drosophila melanogaster, genetics, behavior, olfaction, sex-specific.
Author: Indrani Ganguly
Publisher:
ISBN:
Category :
Languages : en
Pages : 157
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Keywords: Drosophila melanogaster, genetics, behavior, olfaction, sex-specific.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
The ability to respond to and interact with the chemical environment is fundamental to the survival of many species. It governs predator-prey relationships, kin and mate selection, food localization, maternal behaviors and avoidance of environmental toxins. Olfactory behavior is determined by the concerted action of multiple genes that interact with one another and with the environment, be it external, genetic or sexual. Like a number of other quantitative traits, odor-guided behavior shows significant sex-specificity in its phenotypic expression. However, the molecular basis of sexual dimorphism remains poorly defined. This study provides the first example of an autosomal pleiotropic gene that undergoes sex-specific transcriptional regulation to provide the potential for sexually dimorphic olfactory behavior. The phenotypic and molecular characterization of a P-element tagged locus, smi97B, reveals that the multiple PDZ (PSD-95, Discs-large, Zo-1) and LRR (Leucine-Rich Repeat) domain protein, Scribble (Scrib) is responsible for olfactory behavior in adult and larval stages of Drosophila melanogaster. In the adult, scrib is alternatively spliced to generate sex-specific transcripts that are correlated with sexually dimorphic olfactory phenotypes. Head-derived scrib splice variants differ in the number and positions of protein-interaction (PDZ and LRR) domains they encode. Since, Scrib is a synaptic scaffolding protein, these differences may direct the organization of sexually dimorphic synaptic signaling assemblies that contribute to odor-guided behavior.
Author:
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Category :
Languages : en
Pages :
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Author: Deepa Sambandan
Publisher:
ISBN:
Category :
Languages : en
Pages : 121
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Keywords: Genotype by environment interactions, Transcriptional profiling, Epistasis, Behavior, Olfaction, Drosophila.
Author: Carla Mucignat-Caretta
Publisher: CRC Press
ISBN: 1466553413
Category : Medical
Languages : en
Pages : 614
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Book Description
Intraspecific communication involves the activation of chemoreceptors and subsequent activation of different central areas that coordinate the responses of the entire organism—ranging from behavioral modification to modulation of hormones release. Animals emit intraspecific chemical signals, often referred to as pheromones, to advertise their presence to members of the same species and to regulate interactions aimed at establishing and regulating social and reproductive bonds. In the last two decades, scientists have developed a greater understanding of the neural processing of these chemical signals. Neurobiology of Chemical Communication explores the role of the chemical senses in mediating intraspecific communication. Providing an up-to-date outline of the most recent advances in the field, it presents data from laboratory and wild species, ranging from invertebrates to vertebrates, from insects to humans. The book examines the structure, anatomy, electrophysiology, and molecular biology of pheromones. It discusses how chemical signals work on different mammalian and non-mammalian species and includes chapters on insects, Drosophila, honey bees, amphibians, mice, tigers, and cattle. It also explores the controversial topic of human pheromones. An essential reference for students and researchers in the field of pheromones, this is also an ideal resource for those working on behavioral phenotyping of animal models and persons interested in the biology/ecology of wild and domestic species.
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Languages : en
Pages : 0
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Odor-guided behavior is a polygenic trait determined by the concerted expression of multiple loci. Previously, P-element mutagenesis was used to identify single P(lArB) insertions, in a common isogenic background, with homozygous effects on olfactory behavior. Here, we have crossed 12 lines with these smell impaired (SMI) mutations in a half-diallel design (excluding homozygous parental genotypes and reciprocal crosses) to produce all possible 66 doubly heterozygous hybrids with P(lArB) insertions at two distinct locations. The olfactory behavior of the transheterozygous progeny was measured using an assay that quantified the avoidance response to the repellent odorant benzaldehyde. There was significant variation in general combining abilities of avoidance scores among the smi mutants, indicating variation in heterozygous effects. Further, there was significant variation among specific combining abilities of each cross, indicating dependencies of heterozygous effects on the smi locus genotypes, i.e., epistasis. Significant epistatic interactions were identified for nine transheterozygous genotypes, involving 10 of the 12 smi loci. Eight of these loci form an interacting ensemble of genes that modulate expression of the behavioral phenotype. These observations illustrate the power of quantitative genetic analyses to detect subtle phenotypic effects and point to an extensive network of epistatic interactions among genes in the olfactory subgenome.
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ISBN:
Category :
Languages : en
Pages : 126
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Author: Phoebe Kapp Richgels
Publisher:
ISBN:
Category :
Languages : en
Pages : 48
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Animals use olfactory cues in such vital behaviors as finding mates, avoiding predators, and locating food. Behavioral responses to odorants are mediated by a combination of environmental and genetic factors. To examine the extent to which genetic variation in Drosophila melanogaster odorant receptors contributes to olfactory behavior, avoidance behavioral responses to select odorants were examined and odorant receptor alleles from a natural population were sequenced. Behavioral variation was assessed for the structurally similar esters methyl hexanoate and ethyl hexanoate. Furthermore, three odorant receptors that respond to these esters (Or22a, Or35a, and Or47a) as well as one odorant receptor co-expressed with Or22a (i.e., Or22b) were sequenced. Population genetics analyses of sequenced alleles indicated a deviation from neutrality for the intronic region of Or47a. Numerous single nucleotide polymorphisms and insertion/deletion polymorphisms in Or22b, Or35a, and Or47a were associated with variation in behavioral responses to ethyl hexanoate. Significant association profiles for methyl hexanoate, however, were only found for Or22b and Or35a, with some polymorphisms associated with variation in behavioral response to both odorants. These results demonstrate the combinatorial nature of odor coding for structurally similar odorants and how genetic variation that arises during the evolution of odorant receptor genes can play a role in mediating variation in behavioral responses to odorants.
Author: Josh Dubnau
Publisher: Cambridge University Press
ISBN: 1107009030
Category : Medical
Languages : en
Pages : 309
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Book Description
A comprehensive portrayal of the behaviour genetics of the fruit fly (Drosophila melanogaster) and the methods used in these studies.
Author: Mark Anthony Vargo
Publisher:
ISBN:
Category : Fruit-flies
Languages : en
Pages : 608
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