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Author: Ranjita Shegokar
Publisher: Springer Nature
ISBN: 3031316940
Category : Science
Languages : en
Pages : 244
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Book Description
The Peritoneal cavity (PC) is the key metastatic site for intra-abdominal malignancies (e.g., GI tract and rectal cancer). PC sites can be used to target several other diseases where lymphatic drug delivery is desired without dumping large amounts of the drug. Till recently, it was thought that treatment with curative intent was impossible but that was challenged by the introduction of cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC), and PIPAC (pressurized intraperitoneal aerosol chemotherapy). Recently, a growing number of preclinical and clinical studies advocate intraperitoneal (IP) chemotherapy as an alternative post-operative therapy for cancer. Although their effectiveness has been proven both experimentally and clinically, there is still little understanding of the role of drug delivery systems (DDS) in targeting drugs in the intraperitoneal (IP) cavity. There are two main challenges one posed by IP cavity where the residence time of a small molecular weight drug (20 kDa) is not sufficiently long to maintain therapeutic effect. This leads to frequent or continuous dosing. Another challenge is device-related or catheter-related problems, such as catheter obstruction, increased risk of infection, and bowel complications. Overall literature shows that the IP site is satisfactorily explored by clinicians but in terms of drug delivery not that much. One can see a clear-cut gap of expertise exchange between the two fields and guidelines from regulatory lawmakers on new medications./ppbr/ppIn summary, challenges like delivery to IP cavity, tumor or organ-specific targeting, efficient tissue penetration, optimal cellular uptake and intracellular residence of a drug, biocompatibility, toxicity, etc can be easily solved by smartly designing functional drug delivery systems (both nano and micro). Nanotechnologies have always fascinated humans for several decades and are now widely explored in the biomedical field. Diverse types of nanoparticles are being explored around the world, some examples include biodegradable nanoparticles, green nanoparticles, polymeric nanoparticles, lipid nanoparticles, metal nanoparticles, graphene, carbon nanotubes, and several others. Now a day's nanoparticles are gaining interest for drug targeting of chemotherapeutic drugs, immunotherapy, and gene delivery. Whereas microparticles can be explored for delayed drug delivery to the peritoneal cavity due to relatively slow removal from IP fluid. Hydrogels or other adhesive drug delivery may help to enhance peritoneal adhesions; thereby maintaining the balance between benefit and risk. Overall, drug delivery systems are key in IP targeting. That means drug delivery specialist and clinician needs to be connected to get the best out of this route of drug administration./ppbr/ppThe present book is a link between pharmaceutical scientists (drug formulators), clinicians, toxicologists, and regulatory experts. This book also provides a new perspective to researchers to divert or guide their research in an optimal way. Exploring Drug Delivery to the Peritoneum serves as a platform for upcoming technologies especially in the medical devices sector to face up and show potential in delivering drugs. It is a chance for commercial partners like insurance companies and the pharma industry to explore this direction./pp/pp
Author: Ranjita Shegokar
Publisher: Springer Nature
ISBN: 3031316940
Category : Science
Languages : en
Pages : 244
Get Book Here
Book Description
The Peritoneal cavity (PC) is the key metastatic site for intra-abdominal malignancies (e.g., GI tract and rectal cancer). PC sites can be used to target several other diseases where lymphatic drug delivery is desired without dumping large amounts of the drug. Till recently, it was thought that treatment with curative intent was impossible but that was challenged by the introduction of cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC), and PIPAC (pressurized intraperitoneal aerosol chemotherapy). Recently, a growing number of preclinical and clinical studies advocate intraperitoneal (IP) chemotherapy as an alternative post-operative therapy for cancer. Although their effectiveness has been proven both experimentally and clinically, there is still little understanding of the role of drug delivery systems (DDS) in targeting drugs in the intraperitoneal (IP) cavity. There are two main challenges one posed by IP cavity where the residence time of a small molecular weight drug (20 kDa) is not sufficiently long to maintain therapeutic effect. This leads to frequent or continuous dosing. Another challenge is device-related or catheter-related problems, such as catheter obstruction, increased risk of infection, and bowel complications. Overall literature shows that the IP site is satisfactorily explored by clinicians but in terms of drug delivery not that much. One can see a clear-cut gap of expertise exchange between the two fields and guidelines from regulatory lawmakers on new medications./ppbr/ppIn summary, challenges like delivery to IP cavity, tumor or organ-specific targeting, efficient tissue penetration, optimal cellular uptake and intracellular residence of a drug, biocompatibility, toxicity, etc can be easily solved by smartly designing functional drug delivery systems (both nano and micro). Nanotechnologies have always fascinated humans for several decades and are now widely explored in the biomedical field. Diverse types of nanoparticles are being explored around the world, some examples include biodegradable nanoparticles, green nanoparticles, polymeric nanoparticles, lipid nanoparticles, metal nanoparticles, graphene, carbon nanotubes, and several others. Now a day's nanoparticles are gaining interest for drug targeting of chemotherapeutic drugs, immunotherapy, and gene delivery. Whereas microparticles can be explored for delayed drug delivery to the peritoneal cavity due to relatively slow removal from IP fluid. Hydrogels or other adhesive drug delivery may help to enhance peritoneal adhesions; thereby maintaining the balance between benefit and risk. Overall, drug delivery systems are key in IP targeting. That means drug delivery specialist and clinician needs to be connected to get the best out of this route of drug administration./ppbr/ppThe present book is a link between pharmaceutical scientists (drug formulators), clinicians, toxicologists, and regulatory experts. This book also provides a new perspective to researchers to divert or guide their research in an optimal way. Exploring Drug Delivery to the Peritoneum serves as a platform for upcoming technologies especially in the medical devices sector to face up and show potential in delivering drugs. It is a chance for commercial partners like insurance companies and the pharma industry to explore this direction./pp/pp
Author: Amine Souadka
Publisher: Frontiers Media SA
ISBN: 2832546706
Category : Medical
Languages : en
Pages : 130
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Book Description
Peritoneal surface malignancies (PSM) include a heterogeneous group of primary tumors, like peritoneal mesothelioma, and peritoneal metastases from various origins such as ovarian, gastric, colorectal, or appendicular cancers. Their pathophysiology is complex and still not fully elucidated. Historically, due to their dismal prognosis, peritoneal surface malignancies were considered a terminal condition and treated as such in palliative intent.. Surgery has become pivotal in the treatment of PSM and the development of specific techniques of cytoreductive surgery (peritonectomies, “en-bloc” resection) open up a new era of curative intent treatments.
Author: Jorge Coelho
Publisher: Springer Science & Business Media
ISBN: 9400760108
Category : Medical
Languages : en
Pages : 433
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Book Description
This book is part of a series dedicated to recent advances on preventive, predictive and personalised medicine (PPPM). It focuses on the theme of “Drug delivery systems: advanced technologies potentially applicable in personalised treatments”. The critical topics involving the development and preparation of effective drug delivery systems, such as: polymers available, self-assembly, nanotechnology, pharmaceutical formulations, three dimensional structures, molecular modeling, tailor-made solutions and technological tendencies, are carefully discussed. The understanding of these areas constitutes a paramount route to establish personalised and effective solutions for specific diseases and individuals.
Author: Ranjita Shegokar
Publisher: Elsevier
ISBN: 012817871X
Category : Medical
Languages : en
Pages : 248
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Book Description
Drug Delivery Trends examines a drift in the pharmaceutical field across the wide range of dosage forms, drug delivery systems (micro and nanoparticulate), at the regulatory front and on new types of therapies in the market. This volume additionally covers the challenges on drug delivery systems in terms of preclinical and current ways of determining quality and the options to solve the challenges associated with this. Most small-medium scale industries and academics struggle with initial regulatory challenges so a detailed discussion on regulatory trend covers the necessary basic understanding of regulatory procedures and provides the required guidance. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems. - Encompasses trends in drug delivery systems and selected dosage forms - Illustrates regulatory, preclinical and quality principles - Contains in-depth investigation of upcoming types of drug delivery systems
Author: Albert Altchek
Publisher: Elsevier
ISBN: 008049451X
Category : Medical
Languages : en
Pages : 595
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Book Description
This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders.KEY FEATURES* Includes updated information on early diagnosis of ovarian cancer* Reviews new diagnostic techniques for ovarian disorders* Discusses latest information on reproductive technology* Presents translational treatment linking laboratory research with clinical medicine
Author: Gere diZerega
Publisher: Springer Science & Business Media
ISBN: 9780387986104
Category : Medical
Languages : en
Pages : 584
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Book Description
Peritoneal Surgery addresses the response of the peritoneum to injury and the prevention of post-surgical adhesions resulting from general and gynecologic surgery. Adhesions, or scar tissue binding two normally separate surfaces, form when the peritoneum, the membrane covering the abdominal wall and protecting the inner organs, is damaged during surgery, inflammation, or injury. Negative complications from adhesions include pelvic pain, infertility, intestinal obstruction, multiple surgical complications resulting from surgery to remove or pull them apart, and therefore a greater surgical workload and economic burden to the healthcare system. In this book, experts in the field address peritoneal repair, the role of surgical technique to prevent adhesions, adhesion formation, complications of adhesions, and developing technology in the prevention of adhesions.
Author: Dr. Spineanu Eugenia
Publisher: Dr. Spineanu Eugenia
ISBN:
Category : Medical
Languages : en
Pages : 336
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Book Description
Discover a comprehensive guide that demystifies the intricacies of retroperitoneal and peritoneal malignancies in "Navigating the Complexities of Retroperitoneal and Peritoneal Malignancies: From Diagnosis to Survivorship." This in-depth treatise is your ultimate resource for understanding, managing, and thriving through these challenging cancers. Unravel the Mysteries: Dive deep into the world of malignant neoplasms affecting the retroperitoneum and peritoneum. Explore their cellular basis, genetic mechanisms, and the role of oncogenes and tumor suppressor genes. Gain insights into the microenvironmental factors driving these cancers and understand the complexities of metastasis. Comprehensive Clinical Insights: From signs and symptoms to diagnostic imaging, laboratory tests, and staging systems, this treatise equips you with the knowledge to navigate the clinical landscape. Learn about tumor classification, grading, immunohistochemistry, and molecular pathology, allowing you to make informed decisions about diagnosis and treatment. Optimized Treatment Strategies: Get a holistic view of treatment modalities, including surgery, chemotherapy, radiation therapy, and emerging techniques. Understand the principles of radiation oncology, the use of immunotherapy, and the significance of combination therapies in achieving the best outcomes. Patient-Centered Approach: Beyond medical details, we emphasize the importance of patient-centered care. Explore chapters on supportive care, palliative strategies, and holistic approaches to improving the quality of life. Learn about survivorship care plans and long-term effects of treatment, empowering both patients and caregivers. Future-Ready Insights: Stay ahead with a glimpse into the future of cancer care, including personalized medicine, immunotherapy, and ongoing research trends. Understand primary prevention strategies and the significance of global perspectives in malignant neoplasm prevention. Whether you're a healthcare professional seeking in-depth knowledge or a patient and caregiver seeking guidance and support, "Navigating the Complexities of Retroperitoneal and Peritoneal Malignancies" offers a comprehensive and compassionate roadmap. Embrace the complexities, conquer challenges, and embark on a journey towards informed decisions, improved quality of life, and a brighter future.
Author: Mariana Quezado
Publisher: Frontiers Media SA
ISBN: 2832554083
Category : Science
Languages : en
Pages : 129
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Book Description
Precision medicine, or personalized medicine, is related to treatment based on the patient’s individual characteristics. To promote this personalized approach, diseases must accurately be diagnosed; specific biomarkers can predict disease evolution and optimize therapy based on each patient's characteristics such as their genetic background, lifestyle and environmental risk factors. Over the years, we have seen a revolution in pharmacotherapy and management of patients receiving personalized medicine, especially when we consider immunotherapy and specific tyrosine kinases inhibitors. Patients with inflammatory diseases, such as monogenetic diabetes and chronic kidney disease, have benefited from the progress made within the last decade related to our understanding of the genetic basis of diabetes. Similarly, patients in precision oncology, with breast, prostate and blood cancer have experienced better overall survival rates with targeted therapy such as trastuzumab (breast cancer), PARPs inhibitors (prostate cancer), imatinib, ibrutinib and venetoclax (leukemia).
Author: Ranjita Shegokar
Publisher: William Andrew
ISBN: 0323401139
Category : Technology & Engineering
Languages : en
Pages : 291
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Book Description
Emerging Nanotechnologies in Immunology aims to deliver a systematic and comprehensive review of data concerning the nature of interaction and nano-related risks between the nanophamaceuticals currently in the pipeline of S&T development for skin, ocular, and nasal drug delivery, including absorption, toxicity, and the ability to distribute after systemic exposure.The scientific development of manufactured nanomaterials for drug delivery is increasing rapidly. One of the most prominent applications is topical drug delivery, where cutaneous, ocular, and nasal exposure becomes even more relevant. These targets are the first barrier that nanoparticles encounter when in contact with the human body.The contributors addresses a representative set of the broad spectrum of nanopharmaceuticals currently being used, including cationic lipid nanoparticles, polymeric PLGA, PLA nanoparticles, biomacromolecules-based nanoparticles, and other scaffolds tissue engineered skin substitutes. Regulation and risk is also covered, since the safety of these nanophamaceuticals still represents a barrier to their wide innovative use. - Provides the reader with a thorough knowledge of the safety aspects of nanopharmaceuticals which are currently under research - Focuses on the characterization and quantification of the nanopharmaceuticals - Allows readers to understand the correlation between the nature of the materials and their potential nanotoxicological effects - Includes an overview of regulatory aspects related to the R&D of nanopharmaceuticals
Author: Jonathan Fenkel
Publisher: CRC Press
ISBN: 1040137393
Category : Medical
Languages : en
Pages : 220
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Book Description
Quick Reference Dictionary for GI and Hepatology is a unique, pocket-sized reference designed specifically to provide a magnitude of terms and their definitions, guidelines, and references essential to the gastroenterology profession. Led by Dr. Jonathan Fenkel and his contributors, this compact, concise, and informative reference contains over 1000 commonly used GI and hepatology terms and definitions. Additionally, Quick Reference Dictionary for GI and Hepatology offers more than 20 quick reference appendices related to common GI and liver diseases. Some appendices include:• Causes of acute liver failure • Approach to elevated liver enzyme tests • Peptic ulcer disease: therapy and re-bleeding rates • Colorectal cancer surveillance guidelines • Scoring of acute pancreatitis • Types of gallstones Quick Reference Dictionary for GI and Hepatology provides an at-your-fingertips guide for anyone who works in the gastroenterology profession, including gastroenterologists, medical students, residents, fellows, nurse practitioners, physician assistants, office staff, and industry sales representatives.
