Evolution and Regulation of the Transcriptional Response to Oxidative Stress in Vertebrates PDF Download
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Author: Yuhang Hong
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Author: Yuhang Hong
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Author: Pieter Steyn
Publisher: Elsevier
ISBN: 0323149936
Category : Science
Languages : en
Pages : 449
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Book Description
The Biosynthesis of Mycotoxins: A Study in Secondary Metabolism focuses on the biosynthetic analysis of mycotoxins, which are inherently a heterogeneous group of metabolites that are formed along the terpene route and the route polyketide, as well as from amino acids. This book discusses the unique biological properties and structural complexity of the highly specialized secondary microbial metabolites. Organized into 12 chapters, this book starts with an overview of the characteristics of secondary metabolites, including their problematic function and the combination of their structural diversity with their restricted biological occurrence. This text then explains the sporadic occurrence of the mycotoxins as fungal metabolites. Other chapters explore ergochromes, which are a group of light yellow mycotoxins that are isolated from ergot, mold fungi, and lichens. The final chapter discusses the biosynthesis of several unrelated fungal metabolites for which toxicological data are reported. Biochemists, organic chemists, mycologists, enzymologists, plant pathologists, toxicologists, and graduate students will find this book useful.
Author: Stefan Hohmann
Publisher: Springer Science & Business Media
ISBN: 3540456112
Category : Science
Languages : en
Pages : 398
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Book Description
Every cell has developed mechanisms to respond to changes in its environment and to adapt its growth and metabolism to unfavorable conditions. The unicellular eukaryote yeast has long proven as a particularly useful model system for the analysis of cellular stress responses, and the completion of the yeast genome sequence has only added to its power This volume comprehensively reviews both the basic features of the yeast genral stress response and the specific adapations to different stress types (nutrient depletion, osmotic and heat shock as well as salt and oxidative stress). It includes the latest findings in the field and discusses the implications for the analysis of stress response mechanisms in higher eukaryotes as well.
Author:
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Category :
Languages : en
Pages : 0
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Kidney disease is a complex health problem, often coinciding with cardiovascular pathology (e.g. hypertension) and metabolic disturbances (e.g. obesity and diabetes). It is also a disturbingly fast growing global public health problem, e.g. chronic kidney disease affects an estimated ~9-16% of the population. Besides the public health issues this results in a large economic burden as kidney diseases contributes disproportionally to about a quarter of total health care costs. Experimental and clinical data solidly support the view that kidney tissue hypoxia plays a critical and intricate role during the genesis and progression of both chronic and acute kidney diseases. This research field is currently at the very beginning of integrating pre-clinical with clinical research in which hypoxia related mechanism are quantified by non-invasive imaging. In combination with the fact that some key questions remain unanswered, this offers exciting new research perspectives that are waiting to be explored. With this Research Topic we aim to discuss and find answers to the following research question: 1) What are the temporal relationships between hypoxia and kidney disease? 2) Can we demonstration causation between hypoxia and kidney disease? 3) Can renal hypoxia be considered as a treatment target in kidney disease? 4) Can hypoxia (e.g. in the urine) be considered a biomarker of kidney disease? 5) Does hypoxia ramp-up sympathetic activity? 6) Does hypoxia trigger inflammation? 7) Is hypoxia caused by changes in sodium reabsorption and/or mitochondrial function? 8) Which molecular mechanisms are involved in hypoxia in kidney disease? 9) Which gene expressions change due to hypoxia in kidney disease? 10) Can we generate new and translational insights using non-invasive imaging technologies? Our overall aim is identify the mediators/controllers of hypoxia in kidney disease. If we understand more about the sequence of events leading to hypoxia, its regulation and consequences in renal disease, we might be able to have a major impact in clinical practice. I.e. more accurate and earlier diagnosis, novel treatment targets, and novel therapies.
Author: David Costantini
Publisher: Springer Science & Business Media
ISBN: 3642546633
Category : Science
Languages : en
Pages : 359
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Book Description
This book discusses oxidative stress and hormesis from the perspective of an evolutionary ecologist or physiologist. In the first of ten chapters, general historical information, definitions, and background of research on oxidative stress physiology, hormesis, and life history are provided. Chapters 2-10 highlight the different solutions that organisms have evolved to cope with the oxidative threats posed by their environments and lifestyles. The author illustrates how oxidative stress and hormesis have shaped diversity in organism life-histories, behavioral profiles, morphological phenotypes, and aging mechanisms. The book offers fascinating insights into how organisms work and how they evolve to sustain their physiological functions under a vast array of environmental conditions.
Author: Alexandre Guilliermond
Publisher: Merchant Books
ISBN: 9781933998237
Category : Science
Languages : en
Pages : 452
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Book Description
Author: Heinz Decker
Publisher: Springer Science & Business Media
ISBN: 3642131794
Category : Science
Languages : en
Pages : 179
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Book Description
This book describes the interlaced histories of life and oxygen. It opens with the generation of oxygen in ancient stars and its distribution to newly formed planets like the Earth. Free O2 was not available on the early Earth, so the first life forms had to be anaerobic. Life introduced free O2 into the environment through the evolution of photosynthesis, which must have been a disaster for many anaerobes. Others found ways to deal with the toxic reactive oxygen species and even developed a much more efficient oxygen-based metabolism. The authors vividly describe how the introduction of O2 allowed the burst of evolution that created today’s biota. They also discuss the interplay of O2 and CO2, with consequences such as worldwide glaciations and global warming. On the physiological level, they present an overview of oxidative metabolism and O2 transport, and the importance of O2 in human life and medicine, emphasizing that while oxygen is essential, it is also related to aging and many disease states.
Author: Tahira Farooqui
Publisher: John Wiley & Sons
ISBN: 111800194X
Category : Science
Languages : en
Pages : 433
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Book Description
This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. It offers comprehensive reviews of the current understanding of oxidative stress-mediated physiology and pathology as well as directions for future research. It also provides current information on the role of oxidative stress in neurodegenerative diseases, cardiovascular diseases, and various types of cancer mediated by oxidative stress.
Author: Kapuganti Jagadis Gupta
Publisher: John Wiley & Sons
ISBN: 1118790464
Category : Science
Languages : en
Pages : 398
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Book Description
Rapid developments in molecular and systems biology techniques have allowed researchers to unravel many new mechanisms through which plant cells switch over to alternative respiratory pathways. This book is a unique compendium of how and why higher plants evolved alternative respiratory metabolism. It offers a comprehensive review of current research in the biochemistry, physiology, classification and regulation of plant alternative respiratory pathways, from alternative oxidase diversity to functional marker development. The resource provides a broad range of perspectives on the applications of plant respiratory physiology, and suggests brand new areas of research. Other key features: written by an international team of reputed plant physiologists, known for their pioneering contributions to the knowledge of regular and alternative respiratory metabolism in higher plants includes step-by-step protocols for key molecular and imaging techniques advises on regulatory options for managing crop yields, food quality and environment for crop improvement and enhanced food security covers special pathways which are of key relevance in agriculture, particularly in plant post-harvest commodities Primarily for plant physiologists and plant biologists, this authoritative compendium will also be of great value to postdoctoral researchers working on plant respiration, as well as to graduate and postgraduate students and university staff in Plant Science. It is a useful resource for corporate and private firms involved in developing functional markers for breeding programs and controlling respiration for the prevention of post-harvest losses in fruit, vegetables, cut flowers and tubers.
Author: Peter F. Surai
Publisher: Brill Wageningen Academic
ISBN: 9789086868650
Category : Poultry
Languages : en
Pages : 0
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Book Description
The goal of this book is to provide up to date information about the roles of Se in poultry nutrition and health. A special emphasis is given to the role of selenium as an essential part of the integrated antioxidant system. Se in feed and organic Se are characterised in detail with emphasis to selenomethionine as a storage form of Se in the body. Also specific Se-deficiency related diseases in poultry are described and the importance of Se in growth, development, immunity and reproduction is demonstrated. A link between poultry industry and human health via production of Se-eggs and Se-enriched meat is shown.
