Energy Metabolism in the Aging Calorie-restricted Nonhuman Primates PDF Download
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Author: Aarthi Raman
Publisher:
ISBN:
Category :
Languages : en
Pages : 224
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Book Description
Author: Aarthi Raman
Publisher:
ISBN:
Category :
Languages : en
Pages : 224
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Book Description
Author: Richard Weindruch
Publisher: Charles C Thomas Pub Limited
ISBN: 9780398054960
Category : Health & Fitness
Languages : en
Pages : 436
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Book Description
Author: Raymond Pearl
Publisher:
ISBN:
Category : Drosophila
Languages : en
Pages : 220
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Book Description
Author: Gil Atzmon, PhD
Publisher: Springer
ISBN: 1493924044
Category : Medical
Languages : en
Pages : 199
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Book Description
The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for Aging explores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. It touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.
Author: Arthur V. Everitt
Publisher: Springer Science & Business Media
ISBN: 9048185564
Category : Medical
Languages : en
Pages : 327
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Book Description
Food or calorie restriction has been shown in many short-lived animals and the rhesus monkey to prolong life-span. Life-long nutrition studies are not possible in humans because of their long survival. Studies over two to six years in healthy adult humans have, however, shown that a 20% reduction in food or calorie intake slows many indices of normal and disease-related aging. Thus, it is widely believed that long-term reduction in calorie or food intake will delay the onset of age-related diseases such as heart disease, diabetes and cancer, and so prolong life. Over the last 20 or more years there has been a progressive rise in food intake in many countries of the world, accompanied by a rising incidence of obesity. Thus our increasing food and calorie intake has been linked to the rising incidence of cardiovascular disease and diabetes in early adult life. It is accepted that overeating, accompanied by reduced physical exercise, will lead to more age-related diseases and shortening of life-span. The answer is to reduce our calorie intake, improve our diet, and exercise more. But calorie restriction is extremely difficult to maintain for long periods. How then can we solve this problem? Edited by a team of highly distinguished academics, this book provides the latest information on the beneficial effects of calorie restriction on health and life-span. This book brings us closer to an understanding at the molecular, cellular and whole organism level of the way forward.
Author: E.J. Masoro
Publisher: Elsevier
ISBN: 0080528422
Category : Technology & Engineering
Languages : en
Pages : 193
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Book Description
For many years, it has been known that when rats and mice are given a reduced amount of food, their life span is increased and they remain healthy and vigorous at advanced ages. What is the reason for this change in the usual pattern of aging? The evidence is overwhelming that the life extension results from a slowing of aging processes. And the factor responsible is the decrease in caloric intake. The obvious question: How does this factor work? A good question - and the reason that research on the anti-aging action of caloric restriction is today one of the most studied research areas in biological gerontology. For it is felt that if the biological mechanisms of the anti-aging action of caloric restriction can be uncovered, we would gain an understanding of the basic nature of aging processes, which would, in turn, yield possible interventions in human aging. This book aims to provide the growing number of researchers in this field (faculty, postdoctoral trainees, and graduate students) with a detailed knowledge of what is known about caloric restriction within the frame of gerontology, as well as insights on future of this field.
Author: Connie Watkins Bales
Publisher: Springer
ISBN: 1493919296
Category : Medical
Languages : en
Pages : 455
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Book Description
This is the new and fully revised third edition of the well-received text that is the benchmark book in the field of nutrition and aging. The editors (specialists in geriatric nutrition, medical sociology, and clinical nutrition, respectively) and contributors (a panel of recognized academic nutritionists, geriatricians, clinicians, and other scientists) have added a number of new chapters and have thoroughly updated the widely acclaimed second edition. This third edition provides fresh perspectives and the latest scientific and clinical developments on the interaction of nutrition with age-associated disease and provides practical, evidence-based options to enhance this at-risk population’s potential for optimal health and disease prevention. Chapters on a wide range of topics, such as the role of nutrition in physical and cognitive function, and coverage of an array of clinical conditions (obesity, diabetes, heart failure, cancer, kidney disease, osteoporosis), compliment chapters on food insecurity, anti-aging and nutritional supplements, making this third edition uniquely different from previous editions. Handbook of Clinical Nutrition and Aging, Third Edition, is a practical and comprehensive resource and an invaluable guide to nutritionists, physicians, nurses, social workers and others who provide health care for the ever-increasing aging population.
Author: Thomas Seyfried
Publisher: John Wiley & Sons
ISBN: 1118310306
Category : Science
Languages : en
Pages : 482
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Book Description
The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309069890
Category : Technology & Engineering
Languages : en
Pages : 307
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Book Description
This new release presents the wealth of information gleaned about nonhuman primates nutrition since the previous edition was published in 1978. With expanded coverage of natural dietary habits, gastrointestinal anatomy and physiology, and the nutrient needs of species that have been difficult to maintain in captivity, it explores the impact on nutrition of physiological and life-stage considerations: infancy, weaning, immune function, obesity, aging, and more. The committee also discusses issues of environmental enrichment such as opportunities for foraging. Based on the world's scientific literature and input from authoritative sources, the book provides best estimates of nutrient requirements. The volume covers requirements for energy: carbohydrates, including the role of dietary fiber; proteins and amino acids; fats and fatty acids; minerals, fat-soluble and water-soluble vitamins; and water. The book also analyzes the composition of important foods and feed ingredients and offers guidelines on feed processing and diet formulation.
Author: Joseph Erwin
Publisher: Karger Medical and Scientific Publishers
ISBN: 380557312X
Category : Science
Languages : en
Pages : 247
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Book Description
As the number of elderly people in human populations increases, the study of normal aging, age-related disorders, and enhanced longevity is taking on new urgency. Fundamental research will provide means of preventing and effectively treating the most debilitating and distressing aspects of advanced age. Considerations of aging in nonhuman life forms do not aim at life extension, but at an increasing appreciation for the biological role of the aging process in populations, in addition to developing a more comprehensive understanding of the mechanisms of aging. The present volume focuses on primate aging because human characteristics that evolved during their evolution are homologous with those of other primates. Therefore, the research on nonhuman primates will decidedly also contribute to our understanding of the process of human aging. The topics of this volume include brain aging and neurodegenerative diseases, social behavior, cognition and aging, skeletal aging in natural and captive conditions, and consequences of caloric restriction for life and health extension. The great variety of contributions aim at providing a survey of the relevant work in progress and increasing the understanding of normal and pathological aging and life-span enhancement in a variety of nonhuman primate species.
