Effects of Low- and High-intensity Single-leg Resistance Exercise on the Mitogen-activated Protein Kinase ERK1/2 Family Signal Transduction Response in Skeletal Muscle of Untrained Males PDF Download

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Effects of Low- and High-intensity Single-leg Resistance Exercise on the Mitogen-activated Protein Kinase ERK1/2 Family Signal Transduction Response in Skeletal Muscle of Untrained Males

Effects of Low- and High-intensity Single-leg Resistance Exercise on the Mitogen-activated Protein Kinase ERK1/2 Family Signal Transduction Response in Skeletal Muscle of Untrained Males PDF Author: Lemuel W. Taylor
Publisher:
ISBN:
Category : Exercise
Languages : en
Pages : 141

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Book Description
Acute resistance exercise signals responses in the body to promote adaptations to the exercise stimulus. One key response during and following exercise is the role of signal transduction in the skeletal muscle (MAPK family) and its downstream effects on muscular adaptation. Therefore, the purpose of this study was to determine the differential response of a prominent signal transduction pathway following a high-(HI) and a low-intensity (LI) bout of acute resistance exercise. Participants completed a single-legged bout of HI (8-10 reps at 85% of 1-RM) and LI (18-20 reps at 65% of 1-RM) resistance exercise designed to reach muscular fatigue in a randomized, crossover design. Venous blood and muscle biopsies were taken at PRE, 30PST, 2HRPST, and 6HRPST for the two resistance exercise sessions (RES), with an additional blood draw occurring at POST time point. Serum analyses included cortisol, insulin, GH, IGF-1, and IGFBP-3. Muscle analyses included phosphorylated IGF-1R, MEK1, ERK1/2, and activated Elk-1. Statistical analyses utilized a 2X4 MANOVA for muscle and a 2X5 MANOVA for serum variables on delta responses (p>0.05). RES resulted significant increases in cortisol (p