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Author: MIT Critical Data
Publisher: Springer
ISBN: 3319437429
Category : Medical
Languages : en
Pages : 435
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Book Description
This book trains the next generation of scientists representing different disciplines to leverage the data generated during routine patient care. It formulates a more complete lexicon of evidence-based recommendations and support shared, ethical decision making by doctors with their patients. Diagnostic and therapeutic technologies continue to evolve rapidly, and both individual practitioners and clinical teams face increasingly complex ethical decisions. Unfortunately, the current state of medical knowledge does not provide the guidance to make the majority of clinical decisions on the basis of evidence. The present research infrastructure is inefficient and frequently produces unreliable results that cannot be replicated. Even randomized controlled trials (RCTs), the traditional gold standards of the research reliability hierarchy, are not without limitations. They can be costly, labor intensive, and slow, and can return results that are seldom generalizable to every patient population. Furthermore, many pertinent but unresolved clinical and medical systems issues do not seem to have attracted the interest of the research enterprise, which has come to focus instead on cellular and molecular investigations and single-agent (e.g., a drug or device) effects. For clinicians, the end result is a bit of a “data desert” when it comes to making decisions. The new research infrastructure proposed in this book will help the medical profession to make ethically sound and well informed decisions for their patients.
Author: MIT Critical Data
Publisher: Springer
ISBN: 3319437429
Category : Medical
Languages : en
Pages : 435
Get Book Here
Book Description
This book trains the next generation of scientists representing different disciplines to leverage the data generated during routine patient care. It formulates a more complete lexicon of evidence-based recommendations and support shared, ethical decision making by doctors with their patients. Diagnostic and therapeutic technologies continue to evolve rapidly, and both individual practitioners and clinical teams face increasingly complex ethical decisions. Unfortunately, the current state of medical knowledge does not provide the guidance to make the majority of clinical decisions on the basis of evidence. The present research infrastructure is inefficient and frequently produces unreliable results that cannot be replicated. Even randomized controlled trials (RCTs), the traditional gold standards of the research reliability hierarchy, are not without limitations. They can be costly, labor intensive, and slow, and can return results that are seldom generalizable to every patient population. Furthermore, many pertinent but unresolved clinical and medical systems issues do not seem to have attracted the interest of the research enterprise, which has come to focus instead on cellular and molecular investigations and single-agent (e.g., a drug or device) effects. For clinicians, the end result is a bit of a “data desert” when it comes to making decisions. The new research infrastructure proposed in this book will help the medical profession to make ethically sound and well informed decisions for their patients.
Author: Shenyang Guo
Publisher: SAGE
ISBN: 1452235007
Category : Business & Economics
Languages : en
Pages : 449
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Book Description
Provides readers with a systematic review of the origins, history, and statistical foundations of Propensity Score Analysis (PSA) and illustrates how it can be used for solving evaluation and causal-inference problems.
Author: Walter Leite
Publisher: SAGE Publications
ISBN: 1483313395
Category : Social Science
Languages : en
Pages : 225
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Book Description
Practical Propensity Score Methods Using R by Walter Leite is a practical book that uses a step-by-step analysis of realistic examples to help students understand the theory and code for implementing propensity score analysis with the R statistical language. With a comparison of both well-established and cutting-edge propensity score methods, the text highlights where solid guidelines exist to support best practices and where there is scarcity of research. Readers will find that this scaffolded approach to R and the book’s free online resources help them apply the text’s concepts to the analysis of their own data.
Author: Agency for Health Care Research and Quality (U.S.)
Publisher: Government Printing Office
ISBN: 1587634236
Category : Medical
Languages : en
Pages : 236
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Book Description
This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309069882
Category : Social Science
Languages : en
Pages : 610
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Book Description
How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.
Author: William M. Holmes
Publisher: SAGE Publications
ISBN: 1483310817
Category : Social Science
Languages : en
Pages : 361
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Book Description
Using Propensity Scores in Quasi-Experimental Designs, by William M. Holmes, examines how propensity scores can be used to reduce bias with different kinds of quasi-experimental designs and to fix or improve broken experiments. Requiring minimal use of matrix and vector algebra, the book covers the causal assumptions of propensity score estimates and their many uses, linking these uses with analysis appropriate for different designs. Thorough coverage of bias assessment, propensity score estimation, and estimate improvement is provided, along with graphical and statistical methods for this process. Applications are included for analysis of variance and covariance, maximum likelihood and logistic regression, two-stage least squares, generalized linear regression, and general estimation equations. The examples use public data sets that have policy and programmatic relevance across a variety of disciplines.
Author: Donald B. Rubin
Publisher: Cambridge University Press
ISBN: 1139458507
Category : Mathematics
Languages : en
Pages : 5
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Book Description
Matched sampling is often used to help assess the causal effect of some exposure or intervention, typically when randomized experiments are not available or cannot be conducted. This book presents a selection of Donald B. Rubin's research articles on matched sampling, from the early 1970s, when the author was one of the major researchers involved in establishing the field, to recent contributions to this now extremely active area. The articles include fundamental theoretical studies that have become classics, important extensions, and real applications that range from breast cancer treatments to tobacco litigation to studies of criminal tendencies. They are organized into seven parts, each with an introduction by the author that provides historical and personal context and discusses the relevance of the work today. A concluding essay offers advice to investigators designing observational studies. The book provides an accessible introduction to the study of matched sampling and will be an indispensable reference for students and researchers.
Author: Haiyan Bai
Publisher: SAGE Publications
ISBN: 1506378064
Category : Social Science
Languages : en
Pages : 137
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Book Description
A concise, introductory text, Propensity Score Methods and Applications describes propensity score methods (PSM) and how they are used to balance the distributions of observed covariates between treatment conditions as a means to reduce selection bias. This new QASS title specifically focuses on the procedures of implementing PSM for research in social sciences, instead of merely demonstrating the effectiveness of the method. Using succinct and approachable language to introduce the basic concepts of PSM, authors Haiyan Bai and M. H. Clark present basic concepts, assumptions, procedures, available software packages, and step-by-step examples for implementing PSM using real-world data, with exercises at the end of each chapter allowing readers to replicate examples on their own.
Author: David G. Kleinbaum
Publisher: Duxbury
ISBN: 9780495384984
Category : Multivariate analysis
Languages : en
Pages : 906
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Book Description
This bestseller will help you learn regression-analysis methods that you can apply to real-life problems. It highlights the role of the computer in contemporary statistics with numerous printouts and exercises that you can solve using the computer. The authors continue to emphasize model development, the intuitive logic and assumptions that underlie the techniques covered, the purposes, advantages, and disadvantages of the techniques, and valid interpretations of those techniques.
Author: Wei Pan
Publisher: Guilford Publications
ISBN: 1462519490
Category : Psychology
Languages : en
Pages : 417
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Book Description
This book is designed to help researchers better design and analyze observational data from quasi-experimental studies and improve the validity of research on causal claims. It provides clear guidance on the use of different propensity score analysis (PSA) methods, from the fundamentals to complex, cutting-edge techniques. Experts in the field introduce underlying concepts and current issues and review relevant software programs for PSA. The book addresses the steps in propensity score estimation, including the use of generalized boosted models, how to identify which matching methods work best with specific types of data, and the evaluation of balance results on key background covariates after matching. Also covered are applications of PSA with complex data, working with missing data, controlling for unobserved confounding, and the extension of PSA to prognostic score analysis for causal inference. User-friendly features include statistical program codes and application examples. Data and software code for the examples are available at the companion website (www.guilford.com/pan-materials).
