Dispersity, Structure and Phase Changes of Proteins and Bio Agglomerates in Biotechnological Processes PDF Download
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Author: Arno Kwade
Publisher: Springer Nature
ISBN: 3031631641
Category :
Languages : en
Pages : 548
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Book Description
Author: Arno Kwade
Publisher: Springer Nature
ISBN: 3031631641
Category :
Languages : en
Pages : 548
Get Book Here
Book Description
Author: Arno Kwade
Publisher: Springer
ISBN: 9783031631634
Category : Science
Languages : en
Pages : 0
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Book Description
This book serves as a comprehensive summary of the priority program SPP 1934, which focused on understanding the dispersity, structure, and phase changes of proteins and bio-agglomerates in biotechnological processes. Through contributions from various research groups, the program explored how sensitive proteins and bio-agglomerates are affected by the process environment during fermentation, downstream processing, and formulation. It investigated these effects across three size scales: microscale, encompassing single proteins, clusters, crystals, and virus-like particles; mesoscale, focusing on cells and cell clusters; and macroscale, examining overall process dynamics. The main objective was to enhance biotechnological process chains by elucidating the mechanical, thermal, and chemical stresses that impact protein and bio-agglomerate structures. By gaining insights into these stressors, the program aimed to enable precise control measures to mitigate denaturation and unfavorable growth of proteins and cells. This compilation seeks to contribute to the optimization of biotechnological processes, facilitating advancements in various industries.
Author: Philipp Nicolas Depta
Publisher: Cuvillier Verlag
ISBN: 3736969724
Category :
Languages : en
Pages : 297
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Book Description
In order to improve knowledge on macromolecular structural formation and self-assembly, this work proposes a physics-based and data-driven multiscale modeling framework capable of describing structural formation on micro-meter and milli-second scales near molecular-level precision. The framework abstracts macromolecules as anisotropic unit objects and models the interactions and environment using data-driven approaches. The models are parameterized in a bottom-up fashion and validated top-down by comparison with literature and collaborator data for self-assembly of three model system: alginate gelation, hepatitis B virus capsids, and the pyruvate dehydrogenase complex.
Author: Motomu Tanaka
Publisher: Frontiers Media SA
ISBN: 2889747026
Category : Science
Languages : en
Pages : 97
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Book Description
Topic Editor Harada receives financial support from AGC Research Collaboration System with the title “Research on the control of biocompatibility based on the analysis of substrate surface”. The other Topic Editors declare no competing interests
Author: Magdy Elnashar
Publisher: BoD – Books on Demand
ISBN: 9533071796
Category : Technology & Engineering
Languages : en
Pages : 380
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Book Description
The book Biotechnology of Biopolymers omprises 17 chapters covering occurrence, synthesis, isolation and production, properties and applications, biodegradation and modification, the relevant analysis methods to reveal the structures and properties of biopolymers and a special section on the theoretical, experimental and mathematical models of biopolymers. This book will hopefully be supportive to many scientists, physicians, pharmaceutics, engineers and other experts in a wide variety of different disciplines, in academia and in industry. It may not only support research and development but may be also suitable for teaching. Publishing of this book was achieved by choosing authors of the individual chapters for their recognized expertise and for their excellent contributions to the various fields of research.
Author: Masoud Rahman
Publisher: Springer Science & Business Media
ISBN: 3642375553
Category : Science
Languages : en
Pages : 95
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Book Description
In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a “biological identity” to their surfaces (referred to as a “corona”), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called “bio-nano interface,” has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.
Author: Roger G. Harrison
Publisher: Oxford University Press
ISBN: 0190213736
Category : Technology & Engineering
Languages : en
Pages : 577
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Book Description
Designed for undergraduates, graduate students, and industry practitioners, Bioseparations Science and Engineering fills a critical need in the field of bioseparations. Current, comprehensive, and concise, it covers bioseparations unit operations in unprecedented depth. In each of the chapters, the authors use a consistent method of explaining unit operations, starting with a qualitative description noting the significance and general application of the unit operation. They then illustrate the scientific application of the operation, develop the required mathematical theory, and finally, describe the applications of the theory in engineering practice, with an emphasis on design and scaleup. Unique to this text is a chapter dedicated to bioseparations process design and economics, in which a process simular, SuperPro Designer® is used to analyze and evaluate the production of three important biological products. New to this second edition are updated discussions of moment analysis, computer simulation, membrane chromatography, and evaporation, among others, as well as revised problem sets. Unique features include basic information about bioproducts and engineering analysis and a chapter with bioseparations laboratory exercises. Bioseparations Science and Engineering is ideal for students and professionals working in or studying bioseparations, and is the premier text in the field.
Author: Stephan Herminghaus
Publisher: World Scientific
ISBN: 981441770X
Category : Science
Languages : en
Pages : 330
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Book Description
This is a monograph written for the young and advanced researcher entering the field of wet granular matter, and is keen to understand the basic physical principles governing this state of soft matter. It treats wet granulates as an instance of a ternary system, consisting of the grains, a primary, and a secondary fluid. After addressing wetting phenomena in general and outlining the basic facts on dry granular systems, a chapter on basic mechanisms and their effects is dedicated to every region of the ternary phase diagram. Effects of grain shape and roughness are considered as well. Rather than addressing engineering aspects such as existing books on this topic do, the book aims to provide a generalized framework suitable for those who want to understand these systems on a more fundamental basis.
Author: S. Kim R. Williams
Publisher: Springer Science & Business Media
ISBN: 3709101530
Category : Science
Languages : en
Pages : 306
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Book Description
This is a timely collection of important biomedical applications for a set of separation/characterization techniques that are rapidly gaining popularity due to their wide dynamic range, high resolution, and ability to function in most commonly used solvent systems. Importantly, the field-flow fractionation (FFF) technique has recently emerged as a prominent complement to size exclusion chromatography for protein pharmaceuticals. Fractionation with FFF is gentle and preserves protein structural integrity better than existing alternatives. In the present text, different chapters are written by experts in their respective field of application, who offer comparisons between the FFF techniques and other methods for characterizing their special focus material. Practical guide-lines for successful implementation, such as choice of operating conditions, are offered in conjunction with each application. In addition to new instrumentation and approaches that address important current topics, readers are provided with an overall sense of prior (but timeless) major developments that may be overlooked in literature searches.
Author: Mahendra Rai
Publisher: Springer Science & Business Media
ISBN: 3642183123
Category : Science
Languages : en
Pages : 306
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Book Description
Following an introduction to biogenic metal nanoparticles, this book presents how they can be biosynthesized using bacteria, fungi and yeast, as well as their potential applications in biomedicine. It is shown that the synthesis of nanoparticles using microbes is eco-friendly and results in reproducible metal nanoparticles of well-defined sizes, shapes and structures. This biotechnological approach based on the process of biomineralization exploits the effectiveness and flexibility of biological systems. Chapters include practical protocols for microbial synthesis of nanoparticles and microbial screening methods for isolating a specific nanoparticle producer as well as reviews on process optimization, industrial scale production, biomolecule-nanoparticle interactions, magnetosomes, silver nanoparticles and their numerous applications in medicine, and the application of gold nanoparticles in developing sensitive biosensors.
