Diagnosis and Typing of Pseudomonas Aeruginosa from Cystic Fibrosis Patients PDF Download
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Author: Sami Al-bab
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Sami Al-bab
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author: Sami Al-Baba
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Ruth Ann Luna
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Chronic infection with P. aeruginosa is expected in patients with cystic fibrosis (CF), but the ability to delay, prevent, or better manage infection with multiply-resistant P. aeruginosa (MRPA) can potentially increase quality of life and extend survival. The Texas Children's Hospital CF Care Center has identified an endemic MRPA strain (dominant clone), and this study aimed to identify risk factors for acquisition of the clone as well as determine differences in patient outcome associated with subsequent infection with the clone. The study included 71 patients with CF with documented MRPA infection. Designation of patients as members of the dominant clone or a non-dominant clone group was based on molecular typing by rep-PCR of MRPA isolates from respiratory cultures. Patient data was collected from Port CF, the national patient registry of the CF Foundation. Patient demographic information and clinical parameters prior to MRPA infection were analyzed by logistic regression as potential risk factors. Differences in patient outcome including change in BMI, change in FEV1, and hospitalization rate were evaluated by MANOVA. Recent hospitalization ([less or equal to] 90 days) was a statistically significant (p = 0.035) risk factor for acquisition of the dominant clone. Patients hospitalized [less or equal to] 90 days prior to MRPA diagnosis were four times more likely to be infected with the dominant clone, and patients hospitalized 91-180 days prior were almost three times more likely. Increased hospitalization rates were seen in the dominant clone group both pre- (11 more days/year) and post-infection (14 more days/year) as compared to the non-dominant clone group. Patients infected with the endemic strain exhibited poorer outcomes in terms of nutritional status (3.73% decrease/year in BMI %ile) and lung function (3.7% decrease/year in FEV1 %ile). Significant overlap in hospitalization episodes of patients known to be infected with the dominant clone and patients subsequently infected with the dominant clone was observed. Recent hospitalization was a significant risk factor for infection with the dominant MRPA clone, and following infection, patients infected with the endemic strain exhibited declines in nutritional status and lung function and increased hospitalization rates. The results suggest potentially increased virulence and transmissibility of the endemic MRPA strain.
Author: Alan R. Hauser
Publisher: Springer Science & Business Media
ISBN: 1461504333
Category : Medical
Languages : en
Pages : 331
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Book Description
Severe Infections Caused by Pseudomonas aeruginosa emphasizes controversies worldwide in the diagnosis, treatment, prevention and pathogenesis of pseudomonas aeruginosa infections. By including both chapters written by European authors and chapters written by North American experts, the reader is ensured of receiving a broad spectrum of opinions on controversial topics. Special attention is paid to such topics as the diagnosis of hospital-acquired pneumonia caused by p. aeruginosa, scheduled antibiotic therapy for patients with cystic fibrosis, empiric therapy for febrile neurotropenic patients, combination vs. single agent antibiotic therapy for severely ill patients, and alternatives to conventional antibiotic therapies. This excellent overview of our current understanding of pseudomonas aeruginosa pathogenesis will prove useful to clinicians and microbiologists around the globe.
Author: Margaret A. Harrison
Publisher: Nova Publishers
ISBN: 9781594542329
Category : Medical
Languages : en
Pages : 234
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Book Description
Cystic fibrosis (CF), also known as munoviscidosis, is a chronic genetic disease involving the dysfunction of the exocrine glands. This dysfunction is manifested as a deficiency in pancreatic enzymes, accumulation of mucous in airways, and excess salt in sweat. Cystic fibrosis was previously restricted to infancy and childhood but developments in medical treatment and therapy have extended survival considerably. This book includes within its scope research aimed at understanding the genetic linkage in cystic fibrosis, as well as improving the diagnosis and treatment of this disease in both children and adults. Leading-edge scientific research from throughout the world is presented.
Author: Adolf Bauernfeind
Publisher: Birkhäuser
ISBN: 303487359X
Category : Medical
Languages : en
Pages : 337
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Book Description
Infection of the lower respiratory tract is a major determinant of the course of cystic fibrosis. Although numerous efforts have been made to elucidate the specific mechanisms predisposing the respiratory mucosa of cystic fibrosis patients to infection, so far no clinically relevant procedures for completely effective prevention or control of infection have resulted. Hence, in dealing with infections in cystic fibrosis, we continue to rely mainly on antimicrobials. Antiinfective measures are inseparably correlated with microbiology, and the quality of antiinfec tive therapy directly reflects the quality of microbial monitoring. Vali dated guidelines for microbiologic testing and antiinfective use need to be developed and made available to all health providers and their cystic fibrosis patients. Several years ago, the editors cochaired a symposium at the Interna tional Congress of Chemotherapy on the Global Perspectives of Micro biological and Clinical Infectious Diseases in Patients with Cystic Fibrosis. During this half-day symposium, the editors heard reports from several countries around the world with an alarming range of survival for patients with cystic fibrosis. This sent a dramatic message to us that the understanding of this disease, its diagnosis, management and prevention was different in various countries and that patients may be inconsistently served. That is how our journey began.
Author:
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages : 326
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Book Description
Author: Robert B. Fick, Jr.
Publisher: CRC Press
ISBN: 9780849348112
Category : Medical
Languages : en
Pages : 280
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Book Description
Pseudomonas aeruginosa the Opportunist provides an in depth analysis of clinically relevant pathogenetic mechanisms and selected disease states. The book presents the most current discussion of pathogenic mechanisms logically arranged from the microbiology of the Pseudomonadaceae and initial mucosal adherence, progessing to microcolony formation and release of a wide assortment of virulence factors, and closing with the contribution of host cells to the disease process. Cellular and molecular disease mechanisms are covered, including genetic regulation of virulence-associated bacterial products. Future research trends are highlighted as well. Pseudomonas aeruginosa the Opportunist is an excellent reference for bacteriologists, clinical investigators, and practicing clinicians representing a variety of specialties, including ophthalmology, pediatrics, and transplantation.
Author: Sarah S. Long
Publisher: Saunders
ISBN: 9780702034688
Category : Medical
Languages : en
Pages : 1618
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Book Description
"In print, online, or on your mobile device, Principles and Practice of Pediatric Infectious Disease provides the comprehensive and actionable coverage you need to understand, diagnose, and manage the ever-changing, high-risk clinical problems caused by infectious diseases in children and adolescents. With new chapters, expanded and updated coverage, and increased worldwide perspectives, this authoritative medical reference offers the latest need-to-know information in an easily-accessible, high-yield format for quick answers and fast, effective intervention!"--Publisher's website.
Author: Thomas Bjarnsholt
Publisher: Springer
ISBN: 9781489982285
Category : Science
Languages : en
Pages : 0
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Book Description
This book will cover both the evidence for biofilms in many chronic bacterial infections as well as the problems facing these infections such as diagnostics and treatment regimes. A still increasing interest and emphasis on the sessile bacterial lifestyle biofilms has been seen since it was realized that that less than 0.1% of the total microbial biomass lives in the planktonic mode of growth. The term was coined in 1978 by Costerton et al. who defined the term biofilm for the first time.In 1993 the American Society for Microbiology (ASM) recognised that the biofilmmode of growth was relevant to microbiology. Lately many articles have been published on the clinical implications of bacterial biofilms. Both original articles and reviews concerning the biofilm problem are available.
