Development of an Alginate-based Hydrogel Loaded with Multifuncional Gold Nanoparticles for Regenerative Therapies PDF Download
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Author: Marta Sáez Ríos
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
The aim of this project was to develop a multifunctional alginate-based hydrogel modified with peptide-functionalized gold nanoparticles (AuNPs). Hydrogels are versatile materials, commonly used in tissue engineering due to their biocompatibility and tunable properties. In detail, this project explored the modification of alginate hydrogels with functionalized AuNPs incorporating bioactive peptides, such as LF1-11 or RGD, which are known for preventing bacterial infection and promoting cell adhesion, respectively. To this end, this project focused on the synthesis of AuNPs, their conjugation with peptides and, finally, the hybrid hydrogel preparation. In order to optimize and characterize the fabrication process, several physicochemical techniques were used such as UV-visible spectroscopy, transmission electron microscopy or X-ray photoelectron spectroscopy. The synthesis of the hybrid biomaterial was successfully executed and optimized at each step. The fabrication of this hybrid hydrogel proved to be a robust procedure and highly reproducible. Interestingly, the presence of the antimicrobial peptide LF1-11 decreased the adhesion of bacteria to the hydrogel. Further bacterial and cellular assays are thus warranted in order to ascertain the potential applications of this new biomaterial, e.g. as a film/dressing for infected and chronic wounds or injectable gel for bone defects.
Author: Marta Sáez Ríos
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
The aim of this project was to develop a multifunctional alginate-based hydrogel modified with peptide-functionalized gold nanoparticles (AuNPs). Hydrogels are versatile materials, commonly used in tissue engineering due to their biocompatibility and tunable properties. In detail, this project explored the modification of alginate hydrogels with functionalized AuNPs incorporating bioactive peptides, such as LF1-11 or RGD, which are known for preventing bacterial infection and promoting cell adhesion, respectively. To this end, this project focused on the synthesis of AuNPs, their conjugation with peptides and, finally, the hybrid hydrogel preparation. In order to optimize and characterize the fabrication process, several physicochemical techniques were used such as UV-visible spectroscopy, transmission electron microscopy or X-ray photoelectron spectroscopy. The synthesis of the hybrid biomaterial was successfully executed and optimized at each step. The fabrication of this hybrid hydrogel proved to be a robust procedure and highly reproducible. Interestingly, the presence of the antimicrobial peptide LF1-11 decreased the adhesion of bacteria to the hydrogel. Further bacterial and cellular assays are thus warranted in order to ascertain the potential applications of this new biomaterial, e.g. as a film/dressing for infected and chronic wounds or injectable gel for bone defects.
Author: Sougata Jana
Publisher: Springer Nature
ISBN: 9819988268
Category :
Languages : en
Pages : 427
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Book Description
Author: Lakshmi S. Nair
Publisher: World Scientific
ISBN: 178326747X
Category : Science
Languages : en
Pages : 446
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Book Description
"Regenerative engineering, with its ability to foster novel therapeutic techniques and strategies, has emerged as the most versatile and innovative technology of the 21st century. The past few years have seen a significant interest in the development of injectable hydrogels as a delivery system to realize the dream of regenerative engineering. The book will explain synthetic approaches towards developing injectable hydrogels, and the clinical implications and applications of injectable hydrogels for engineering various tissues. Injectable Hydrogels for Regenerative Engineering is the first of its kind to bring together the fields of injectable hydrogels and regenerative engineering to give a perspective of the emerging therapeutic strategies for a wide audience."--
Author: Tapan Kumar Giri
Publisher: Woodhead Publishing
ISBN: 0128216506
Category : Technology & Engineering
Languages : en
Pages : 592
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Book Description
Plant and Algal Hydrogels for Drug Delivery and Regenerative Medicine offers a materials-focused and systematic overview of biopolymeric hydrogels utilized for biomedical applications. The book details the synthesis and characterization of plant and algal-based hydrogels, with each chapter addressing a separate polysaccharide hydrogel type. Specific applications in drug delivery and regenerative medicine are also discussed, highlighting the efficacy, biocompatibility, benefits and challenges for each polysaccharide hydrogel subtype. There is increasing demand for biomaterials which reduce/prevent the host response, inflammation and rejection, hence this book provides a timely resource. Biopolymeric hydrogels have skyrocketed because of their necessity in in vivo applications. They create an environment similar to living tissue, which is both biocompatible and biodegradable. Plant and algal polysaccharides in particular are well-equipped with functional groups that are easily modified for beneficial results. - Systematically covers each plant and algal polysaccharide hydrogel subtype, from starch-based hydrogels to pectin and alginate-based hydrogels - Provides an end-to-end description of the synthesis, characterization and application of biopolymeric hydrogels for drug delivery and regenerative medicine - Appeals to a diverse readership, including those in biomedicine, pharmacy, polymer chemistry, biochemistry, materials science, biomedical engineering, and other biotechnology related disciplines
Author: Md Saquib Hasnain
Publisher: CRC Press
ISBN: 042965748X
Category : Medical
Languages : en
Pages : 611
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Book Description
This new volume explores the latest research on the use of alginate as a biopolymer in various biomedical applications and therapeutics. The uses of alginates and modified alginates discussed in this book include tissue regeneration, encapsulation and delivery of drugs, nucleic acid materials, proteins and peptides, genes, herbal therapeutic agents, nutraceuticals, and more. This book also describes the synthesis and characterizations of various alginate and modified alginate systems, such as hydrogels, gels, composites, nanoparticles, scaffolds, etc., used for the biomedical applications and therapeutics. Alginate, a biopolymer of natural origin, is of immense interest for its variety of applications in pharmaceuticals (as medical diagnostic aids) and in materials science. It is the one of the most abundant natural biopolymers and is considered an excellent excipient because of its non-toxic, stable, and biodegradable properties. Several research innovations have been made on applications of alginate in drug delivery and biomedicines. There needs to be a thorough understanding of the synthesis, purification, and characterization of alginates and its derivatives for their utility in healthcare fields, and this volume offers an abundance of information toward that end.
Author: Thakur Raghu Raj Singh
Publisher: CRC Press
ISBN: 1351648276
Category : Medical
Languages : en
Pages : 289
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Book Description
Hydrogels are crosslinked, macromolecular polymeric materials arranged in a three-dimensional network, which can absorb and retain large amounts of water. Hydrogels are commonly used in clinical practice and experimental medicine for a wide range of applications, including drug delivery, tissue engineering and regenerative medicine, diagnostics, cellular immobilization, separation of biomolecules or cells, and barrier materials to regulate biological adhesions. This book elucidates the underlying concepts and emerging applications of hydrogels and will provide key case studies and critical analysis of the existing research.
Author: Che J. Connon
Publisher: Royal Society of Chemistry
ISBN: 1849737983
Category : Medical
Languages : en
Pages : 238
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Book Description
Leading experts provide a comprehensive overview of recent progress in the synthesis of different hydrogels and their biomedical applications.
Author: J. Miguel Oliveira
Publisher: Academic Press
ISBN: 0128242256
Category : Science
Languages : en
Pages : 851
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Book Description
Hydrogels for Tissue Engineering and Regenerative Medicine: From Fundaments to Applications provides the reader with a comprehensive, concise and thoroughly up-to-date resource on the different types of hydrogels in tissue engineering and regenerative medicine. The book is divided into three main sections that describe biological activities and the structural and physicochemical properties of hydrogels, along with a wide range of applications, including their combination with emerging technologies. Written by a diverse range of international academics for professionals, researchers, undergraduate and graduate students, this groundbreaking publication fills a gap in literature needed in the tissue engineering and regenerative medicine field. - Reviews the fundamentals and recent advances of hydrogels in tissue engineering and regenerative medicine applications - Presents state-of-the-art methodologies for the synthesis and processing of different types of hydrogels - Includes contributions by leading experts in engineering, the life sciences, microbiology and clinical medicine
Author: Agnieszka Kaczmarek-Pawelska
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 0
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Book Description
This chapter presents the following multipotential applications of alginate-based hydrogels in tissue healing and drug delivery. It contains state of the art and summary of the literature reports, which demonstrate that alginate-based hydrogels have a great potential in tissue healing. Sodium alginate (SA) is mainly used in medical devices for healing of wounds, scars, injuries of bones, regeneration of joint cartilage, and scaffold for cell growth and in drug delivery systems (DDSs). The latest literature describes the effects of laboratory tests and in vivo, which confirm the validity of its use as a biomaterial. Alginate biodegradable scaffolds can be a template that provides a suitable substrate for cellular growth while matching the physiochemical properties of the native extracellular matrix (ECM). Matching scaffold stiffness to the surrounding tissue and optimising its rate of degradation ensure that the infiltrating cells remain viable, maintain their desired phenotype and coordinate their response over the entirety of the wound healing process.
Author: Tapan Kumar Giri
Publisher: Elsevier
ISBN: 0323957943
Category : Science
Languages : en
Pages : 312
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Book Description
Polysaccharide Hydrogels for Drug Delivery and Regenerative Medicine is an archival reference for researchers, students and scientists working on hydrogels based on microbial and animal sources. The book contains Information regarding their synthesis, characterization, and applications in the field of drug delivery and regenerative medicine. Each chapter addresses a separate polysaccharide hydrogel and its suitability in drug delivery and/or regenerative medicine. This is a novel resource that brings together a panel of highly accomplished experts in the field of natural polysaccharides to discuss basic causes and specific problems related to drug delivery and regenerative medicine. Presents detailed practical and theoretical concepts Includes fundamentals and methodologies for hydrogel preparation Covers all hydrogels and specific applications in the field of drug delivery and tissue engineering
