Design and Applications of Biodegradable and Photoresponsive Polymers Based on Alkoxyphenacyl and Coumarin Moieties PDF Download
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Author: Elaheh A. Chamsaz
Publisher:
ISBN:
Category : Coumarins
Languages : en
Pages : 251
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Book Description
Photoresponsive materials have unique properties which makes them attractive for biomedical applications such as targeted drug delivery and micropatterned devices. This dissertation utilized a unique approach for incorporation of photoresponsive moieties, alkoxyphenacyl or coumarin chromophores within polymer backbone to synthesize photodegradable polycarbonates, and polyesters. The alkoxyphenacyl polycarbonates showed efficient chain scission upon irradiation at 300 nm as evidenced by 1H NMR, SEC, and UV-Vis spectroscopy. The biocompatibility and biodegradability of photoresponsive alkoxyphenacyl based polycarbonates enables the development of nanoparticles and microfilms, encapsulated with drugs, which in turn can be used as a platform for drug delivery applications. In similar approach, coumarin polyesters showed chain scission upon irradiation at 254 nm and crosslinked upon irradiation at 350 nm as evidenced by 1H NMR, SEC, ATR-IR, and UV-Vis spectroscopy. The properties of the polymers were modulated by the functional groups or the co-monomers used in the polymerization. Biocompatibility and biodegradability of photoresponsive coumarin based polyesters enables the development of micropatterned device as a nerve guidance conduit. Additionally, antimicrobial coatings synthesized from cationic coumarin polyesters showed high efficacy towards inhibiting Pseudomonas aeruginosa attachment and biofilm formation, without significant cytotoxicity. These features make coumarin polyesters attractive candidates for applications such as antimicrobial coatings for implants or medical devices.
Author: Elaheh A. Chamsaz
Publisher:
ISBN:
Category : Coumarins
Languages : en
Pages : 251
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Book Description
Photoresponsive materials have unique properties which makes them attractive for biomedical applications such as targeted drug delivery and micropatterned devices. This dissertation utilized a unique approach for incorporation of photoresponsive moieties, alkoxyphenacyl or coumarin chromophores within polymer backbone to synthesize photodegradable polycarbonates, and polyesters. The alkoxyphenacyl polycarbonates showed efficient chain scission upon irradiation at 300 nm as evidenced by 1H NMR, SEC, and UV-Vis spectroscopy. The biocompatibility and biodegradability of photoresponsive alkoxyphenacyl based polycarbonates enables the development of nanoparticles and microfilms, encapsulated with drugs, which in turn can be used as a platform for drug delivery applications. In similar approach, coumarin polyesters showed chain scission upon irradiation at 254 nm and crosslinked upon irradiation at 350 nm as evidenced by 1H NMR, SEC, ATR-IR, and UV-Vis spectroscopy. The properties of the polymers were modulated by the functional groups or the co-monomers used in the polymerization. Biocompatibility and biodegradability of photoresponsive coumarin based polyesters enables the development of micropatterned device as a nerve guidance conduit. Additionally, antimicrobial coatings synthesized from cationic coumarin polyesters showed high efficacy towards inhibiting Pseudomonas aeruginosa attachment and biofilm formation, without significant cytotoxicity. These features make coumarin polyesters attractive candidates for applications such as antimicrobial coatings for implants or medical devices.
Author: Weizheng Fan
Publisher:
ISBN:
Category : Biomedical materials
Languages : en
Pages : 84
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Book Description
Stimuli responsive polymers show noticeable changes in their properties in response to environmental stimuli and are used in many applications. Various stimuli such as pH, temperature, and in our case, light have been used to bring about the desired effect. Due to their tunable photoresponsive properties, coumarin and its derivatives have been widely used in many functional polymeric materials. The first part of the thesis was focused on the development of visible light responsive coumarin chromophores. These new coumarin derivatives have the maximum UV absorption between 390-420nm, which could enable their utility in biomedical chemistry in future. The second part of this thesis was focused on the development of a class of low moduli photoresponsive polymers, based on the coumarin photoactive unit. These new photoresponsive materials can crosslink under 350nm irradiation. The new polymers have low moduli and show viscous properties before irradiation. Upon crosslinking they display a significant change in physical and mechanical properties. In order to extend the applications of these materials, we prepared a series of photoresponsive polymer/inorganic composite materials with silica. We believe, these polymers have the potential for various biomedical applications such as in filling voids in dental and osteological applications.
Author: Wei Zhang
Publisher: John Wiley & Sons
ISBN: 1119075726
Category : Science
Languages : en
Pages : 624
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Book Description
The first and only exhaustive review of the theory, thermodynamic fundamentals, mechanisms, and design principles of dynamic covalent systems Dynamic Covalent Chemistry: Principles, Reactions, and Applications presents a comprehensive review of the theory, thermodynamic fundamentals, mechanisms, and design principles of dynamic covalent systems. It features contributions from a team of international scientists, grouped into three main sections covering the principles of dynamic covalent chemistry, types of dynamic covalent chemical reactions, and the latest applications of dynamic covalent chemistry (DCvC) across an array of fields. The past decade has seen tremendous progress in (DCvC) research and industrial applications. The great synthetic power and reversible nature of this chemistry has enabled the development of a variety of functional molecular systems and materials for a broad range of applications in organic synthesis, materials development, nanotechnology, drug discovery, and biotechnology. Yet, until now, there have been no authoritative references devoted exclusively to this powerful synthetic tool, its current applications, and the most promising directions for future development. Dynamic Covalent Chemistry: Principles, Reactions, and Applications fills the yawning gap in the world literature with comprehensive coverage of: The energy landscape, the importance of reversibility, enthalpy vs. entropy, and reaction kinetics Single-type, multi-type, and non-covalent reactions, with a focus on the advantages and disadvantages of each reaction type Dynamic covalent assembly of discrete molecular architectures, responsive polymer synthesis, and drug discovery Important emerging applications of dynamic covalent chemistry in nanotechnology, including both material- and bio-oriented directions Real-world examples describing a wide range of industrial applications for organic synthesis, functional materials development, nanotechnology, drug delivery and more Dynamic Covalent Chemistry: Principles, Reactions, and Applications is must-reading for researchers and chemists working in dynamic covalent chemistry and supramolecular chemistry. It will also be of value to academic researchers and advanced students interested in applying the principles of (DCvC) in organic synthesis, functional materials development, nanotechnology, drug discovery, and chemical biology.
Author: Gregg B. Fields
Publisher: Academic Press
ISBN:
Category : Medical
Languages : en
Pages : 828
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Book Description
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volumehas been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 275 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchers in all fields of life sciences. Key Features * Solid-phase peptide synthesis * Applications of peptides for structural and biological studies * Characterization of synthetic peptides
Author: Istvan Benedek
Publisher: CRC Press
ISBN: 0824751140
Category : Technology & Engineering
Languages : en
Pages : 678
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Book Description
Pressure-Sensitive Adhesives and Applications, Second Edition explains how pressure-sensitive adhesives (PSAs) work, why they are used, and the technology used to manufacture them. This second edition features the latest developments in the field. Dr. Benedek discusses the factors that affect the rheology and special flow characteristics responsible for the adhesivity of liquid and solid PSAs. His book explores the viscoelastic behavior of PSAs, and compares them to plastics, rubbers, and polymers properties and examines the parameters that influence the conversion process of PSAs from the coating of carrier materials to the properties of the final laminate. The author covers adhesion/cohesion balance, time-temperature dependence of pressure sensitivity, chemical composition, coating properties, and coating processes affect the adhesive properties of PSA and their end products and how application-specific performance indices are used to determine the formulation and manufacture of raw materials. In addition, up-to-date coating machines, converting technology, and environmental considerations in the manufacture of PSA final products as well as industry-specific methods of testing for quality assurance and control are discussed. Pressure-Sensitive Adhesives and Applications, Second Edition combines the theoretical basis of pressure sensitivity with the practical aspects of manufacturing, testing, and use of PSAs. Readers are offered an exhaustive as well as comparative look at the engineering of plastics, adhesives, and pressure-sensitives, resulting in an indispensable, up-to-date reference for adhesive and polymer chemists and technologists.
Author: Jacques Lalevée
Publisher: John Wiley & Sons
ISBN: 1848217420
Category : Technology & Engineering
Languages : en
Pages : 452
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Book Description
The design and development of dyes and chromophores have recently attracted much attention in various research fields such as materials, radiation curing, (laser) imaging, optics, medicine, microelectronics, nanotechnology, etc.. In this book, the recent research for the use of dyes and chromophores in polymer science is presented. The interaction of the visible light with the dyes or the selected chromophores is particularly important in different fields (e.g. for photovoltaic, display applications (LED ...), laser imaging or laser direct writing, green chemistry with sunlight induced photopolymerization etc ...). This book gives an overview of the dyes and chromophores for all the important fields.
Author: Dennis W. Smith
Publisher: John Wiley & Sons
ISBN: 1118850084
Category : Science
Languages : en
Pages : 671
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Book Description
Handbook of Fluoropolymer Science and Technology A comprehensive handbook on fluoropolymer synthesis, characterization, and processing Fluoropolymers, one of the more durable classes of polymer materials, are known to enable novel technologies as a result of their remarkable properties. As key components in industry applications, fluoropolymers have established commercial interest and scientists have discovered more efficient approaches of handling them. This book reviews up-to-date fluoropolymer platforms as well as recently discovered methods for the preparation of fluorinated materials. It focuses on synthesis, characterization, and processing aspects, providing guidelines for practicing scientists and engineers. In addition, the book covers: Concepts and studies from leading international laboratories, including academia, government, and industrial institutions Emerging technologies and applications in energy, optics, space exploration, fuel cells, microelectronics, gas separation membranes, biomedical instrumentation, and more Current environmental concerns associated with fluoropolymers, relevant regulations, and growth opportunities Overall, the chapters provide coverage of chemical methods and help the reader further understand how fluoropolymer research provides solutions for material challenges. The concepts in this book also inspire professionals to identify new markets and funding sources for fluoropolymer research and development.
Author: Springer
Publisher: Springer
ISBN: 9783662148624
Category :
Languages : en
Pages : 288
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Book Description
Author: Antonina Lavrentieva
Publisher: Springer Nature
ISBN: 3030767698
Category : Science
Languages : en
Pages : 256
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Book Description
This book reviews the current knowledge on tunable hydrogels, including the range of different materials and applications, as well as the existing challenges and limitations in the field. It covers various aspects of the material design, particularly highlighting biological responsiveness, degradability and responsiveness to external stimuli. In this book, readers will discover original research data and state-of-the-art reviews in the area of hydrogel technology, with a specific focus on biotechnology and medicine. Written by leading experts, the contributions outline strategies for designing tunable hydrogels and offer a detailed evaluation of the physical and synthetic methods currently employed to achieve specific hydrogel properties and responsiveness. This highly informative book provides important theoretical and practical insights for scholars and researchers working with hydrogels for biomedical and biotechnological applications.
Author: Alphonsus V. Pocius
Publisher: Hanser Gardner Publications
ISBN: 9781569903193
Category : Technology & Engineering
Languages : en
Pages : 319
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Book Description
This book describes, in clear, understandable language, the three main disciplines of adhesion technology:
