Author: James Devillers
Publisher: CRC Press
ISBN: 1351647695
Category : Medical
Languages : en
Pages : 479
Get Book Here
Book Description
There is a compelling need for new drugs and efficient treatments against mosquito-borne diseases. Environmentally safe, but effective insecticides that address the problems of resistance are required. Computational Design of Chemicals for the Control of Mosquitoes and Their Diseases explains how the search for new substances effective against mosquitoes and their diseases has benefited from the use of in silico techniques. QSAR modeling is suited to identify the key structural features and/or physicochemical properties explaining an activity and to propose candidate molecules for further evaluation by laboratory tests. Homology modeling is useful to approximate the 3D structure of proteins of interest. Pharmacophore modeling is a powerful means to capture the chemical features responsible for an activity and to identify new potentially active compounds via the virtual screening of databases. Fugacity modeling and a wealth of other modeling paradigms are useful for risk assessment in vector borne disease control.
Author: James Devillers
Publisher: CRC Press
ISBN: 1498741819
Category : Medical
Languages : en
Pages : 473
Get Book Here
Book Description
There is a compelling need for new drugs and efficient treatments against mosquito-borne diseases. Environmentally safe, but effective insecticides that address the problems of resistance are required. Computational Design of Chemicals for the Control of Mosquitoes and Their Diseases explains how the search for new substances effective against mosquitoes and their diseases has benefited from the use of in silico techniques. QSAR modeling is suited to identify the key structural features and/or physicochemical properties explaining an activity and to propose candidate molecules for further evaluation by laboratory tests. Homology modeling is useful to approximate the 3D structure of proteins of interest. Pharmacophore modeling is a powerful means to capture the chemical features responsible for an activity and to identify new potentially active compounds via the virtual screening of databases. Fugacity modeling and a wealth of other modeling paradigms are useful for risk assessment in vector borne disease control.
Author: Subhash C. Basak
Publisher: Elsevier
ISBN: 0323857140
Category : Science
Languages : en
Pages : 503
Get Book Here
Book Description
Big Data Analytics in Chemoinformatics and Bioinformatics: With Applications to Computer-Aided Drug Design, Cancer Biology, Emerging Pathogens and Computational Toxicology provides an up-to-date presentation of big data analytics methods and their applications in diverse fields. The proper management of big data for decision-making in scientific and social issues is of paramount importance. This book gives researchers the tools they need to solve big data problems in these fields. It begins with a section on general topics that all readers will find useful and continues with specific sections covering a range of interdisciplinary applications. Here, an international team of leading experts review their respective fields and present their latest research findings, with case studies used throughout to analyze and present key information. - Brings together the current knowledge on the most important aspects of big data, including analysis using deep learning and fuzzy logic, transparency and data protection, disparate data analytics, and scalability of the big data domain - Covers many applications of big data analysis in diverse fields such as chemistry, chemoinformatics, bioinformatics, computer-assisted drug/vaccine design, characterization of emerging pathogens, and environmental protection - Highlights the considerable benefits offered by big data analytics to science, in biomedical fields and in industry
Author: Azamal Husen
Publisher: CRC Press
ISBN: 1003857639
Category : Science
Languages : en
Pages : 477
Get Book Here
Book Description
Malaria continues to affect a large population of the world, especially in third world countries. The spread of drug-resistant parasites demonstrates the need for antimalarial agents with various modes of action. The search for remedies derived from medicinal plants for the treatment of malaria is reliant on accurate ethnobotanical and ethnopharmacological information obtained from traditional medical practitioners. Antimalarial Medicinal Plants provides information on bioactive compounds and therapeutic potentials of several antimalarial plant species found around the globe. This book evaluates these plant species with respect to their biology, diversity, distribution, and pharmacological values. A volume in the Exploring Medicinal Plants series, this book highlights trends, technologies, processes, and services important to and necessary for efficient production, use, and understanding of medicinal qualities of antimalarial plants. It critically examines claims made by traditional medical practitioners with scientific validations for safe herbal drug formulation. It is a reference work for researchers of herbal medicine, traditional healers, pharmacists, and students associated with plant sciences and economic botany.
Author: Conference Series
Publisher: ConferenceSeries
ISBN:
Category : Business & Economics
Languages : en
Pages : 76
Get Book Here
Book Description
March 18-20, 2019 Edinburgh, Scotland Bio-Pharmaceutics,Pharmaceutical Chemistry,Drug Targeting and Design,Pharmacokinetics and Pharmacodynamics in Drugs,Pharmaceutical Formulation,Pharmaceutical Manufacturing,Pharmaceutical Nanotechnology,Novel Drug Delivery Systems,Smart Drug Delivery Systems,Nanomedicine and Biomedical Applications,Biomaterials in Drug Delivery,Vaccine Drug Delivery Systems,Medical Devices for Drug Delivery,Biologics & Biosimilars,Pharmaceutical Analysis,Pharmaceutical Process Validation,Pharmaceutical Packaging,Clinical Trials and Clinical Research,Pharmacogenetics and Genomics,Regulatory Affairs and Intellectual Property Rights,Industrial and Physical Pharmacy,Clinical and Hospital Pharmacy,Pharmacovigilance and Drug Safety,Pharmacy Education and Practice,
Author: Tarun Jha
Publisher: CRC Press
ISBN: 1003817653
Category : Medical
Languages : en
Pages : 491
Get Book Here
Book Description
Matrix metalloproteinases (MMPs) have been established as promising biomolecular targets for novel drug design and discovery against numerous major disease conditions including various cancers, cardiovascular, neurodegenerative, inflammatory diseases, and more. This book covers various modern molecular modeling methodologies particularly related to MMP inhibitors. Included in the text are descriptions of ligand-based drug designing and structure-based drug designing modeling strategies for designing potential and target specific or selective MMPIs. This book will benefit those who are looking for an in-depth text on the design and discovery processes of novel and selective MMPIs. Features Describes modeling strategies applied to MMPs Elaborates on the designing strategies of MMPs specifically Includes in-depth analyses of related case studies Acts as a guide for medicinal chemists, not only from pharmaceutical industries, but also from academia Covers various modern molecular modeling methodologies, particularly related to MMPIs
Author: James Devillers
Publisher: CRC Press
ISBN: 1466513217
Category : Science
Languages : en
Pages : 416
Get Book Here
Book Description
Juvenile hormones (JHs) are a group of structurally related sesquiterpenes secreted by the insect corpora allata. They affect most insect life-cycle stages and physiological functions, including embryogenesis, larval and adult development, metamorphosis, reproduction, metabolism, diapause, polyethism, and migration. Juvenoids such as methoprene, hydroprene, kinoprene, pyriproxyfen, and fenoxycarb are man-made chemicals that mimic the structure and/or activity of JHs, selectively targeting and disrupting the endocrine system of insects. They are particularly suited as larvicides for the control of pest and disease vectoring insects such as mosquitoes. Juvenile Hormones and Juvenoids: Modeling Biological Effects and Environmental Fate discusses the various modeling approaches that can be used to study the mechanism of action of JHs in insects and to estimate the adverse effects and the environmental fate of the juvenoids that mimic their activity. This book is the third of the QSAR in Environmental and Health Sciences series, but the first dedicated to the use of QSAR and other in silico techniques to provide these insights into JHs and their analogs. With contributions by an international team of scientists, the book begins with a historical survey of JHs and juvenoids. It then discusses biosynthesis of sesquiterpenoids followed by chapters covering JH activity such as morph-specific JH titers in crickets, and JH analog activity including soldier-specific organ development in termites and the role of methoprene in gene transcription. The book examines modeling approaches applied to resistance to JH analogs, to population dynamics of nontarget species in the presence of juvenoids, and to SAR and QSAR of JH mimics. The book concludes with a discussion on the use of multicriteria analysis for selecting insecticides for vector control.
Author: Joel Coats
Publisher: Academic Press
ISBN: 0323854125
Category : Science
Languages : en
Pages : 360
Get Book Here
Book Description
Advances in Arthropod Repellents offers the most current knowledge on arthropod repellents. This area of study is quickly evolving as mosquito- and tick-borne diseases become more prevalent worldwide. Written by global arthropod repellent experts, this book begins by delving into molecule discovery and assay development that is followed by the latest research and investigations of repellent developments and effects. The book then offers readers a look into the global field, semi-field, and laboratory trials using various insect repellents, ranging from Africa, Australia, Europe, South America and the United States. Lastly, it examines the future of spatial repellents and expert insight. This book is a valuable resource for entomologists and vector control researchers and practitioners. Public health officials and developers in private pest control companies, as well as readers in academia will find this a useful resource to learn the latest information available on controlling the spread of arthropod-borne diseases with repellents. - Discusses recent progress on understanding how insect repellents work, as well as modern methods for finding new molecules and formulations - Edited by a team whose expertise includes cutting-edge insect repellent research and development - Serves as a reference and resource that will be useful to a wide variety of professionals, particularly those in public health and vector control
Author:
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 230
Get Book Here
Book Description
Author:
Publisher: Academic Press
ISBN: 0128029137
Category : Science
Languages : en
Pages : 147
Get Book Here
Book Description
The scope of this volume of Progress in Molecular Biology and Translational Science includes the molecular regulation of olfactory processes in vertebrates and insects including detailed discussion of olfactory proteins, signaling cascades and olfactory receptor modeling. In addition, because insect olfaction is an important and emerging field, it is also discussed in the context of key research questions such as disruption of host-finding by insect disease vectors, elucidation of the diverse range of compounds that are detected by insects, and the detection of pheromones by moths. Comprehensive coverage of molecular processes in olfaction of vertebrates and insects Focus on the emerging field of insect olfaction Contributions by leading research groups in their fields, from a range of countries Discusses fundamental knowledge and also key applications being addressed by the research
