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Author: David Pertzborn
Publisher:
ISBN:
Category :
Languages : de
Pages : 0
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Book Description
Head and neck cancer is a global health problem with an average of 890,000 new cases and 450,000 deaths per year. Despite ongoing research into diagnosis and treatment options, the overall five-year survival rate has not significantly increased in the last decades. One major challenge lies in the heterogeneity and complexity of head and neck cancers, which comprise a diverse group of tumors that arise from different cell types and anatomical locations in the head and neck region. In case of surgical treatment, up to now the main challenge is a reliable intraoperative assessment and the complete resection of the tumor. Currently used intraoperative in vivo imaging devices are lacking the ability to clearly define the tumor margins. In this work I analyzed head and neck squamous cell carcinomas (HNSCC) and salivary gland carcinomas (SGC) and combined novel spectral and molecular imaging methods with deep learning based data analysis to overcome clinical challenges in treatment and diagnosis of HNSCC and SGC. The two imaging methods were matrix assisted laser desorption/ionization imaging (MALDI) and hyperspectral imaging (HSI). MALDI imaging aims to provide a label- free, spatially resolved measurement of the abundance of biomolecules by using the difference in their mass-to-charge ratio. This leads to a mass spectrum for each location of a given sample. HSI on the other hand measures the interaction of a sample with a broad light spectrum ranging from the visible to the infrared. This thesis is based on three studies. In the first two studies, I was able to show that complex medical problems in head and neck cancer diagnosis and treatment can be addressed by combining novel imaging techniques with deep learning based data analysis. In the third one, I helped to show, that there is no tumor specific uptake of ICG by combining and analyzing fluorescence microscopy and classical histopathological data.
Author: David Pertzborn
Publisher:
ISBN:
Category :
Languages : de
Pages : 0
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Book Description
Head and neck cancer is a global health problem with an average of 890,000 new cases and 450,000 deaths per year. Despite ongoing research into diagnosis and treatment options, the overall five-year survival rate has not significantly increased in the last decades. One major challenge lies in the heterogeneity and complexity of head and neck cancers, which comprise a diverse group of tumors that arise from different cell types and anatomical locations in the head and neck region. In case of surgical treatment, up to now the main challenge is a reliable intraoperative assessment and the complete resection of the tumor. Currently used intraoperative in vivo imaging devices are lacking the ability to clearly define the tumor margins. In this work I analyzed head and neck squamous cell carcinomas (HNSCC) and salivary gland carcinomas (SGC) and combined novel spectral and molecular imaging methods with deep learning based data analysis to overcome clinical challenges in treatment and diagnosis of HNSCC and SGC. The two imaging methods were matrix assisted laser desorption/ionization imaging (MALDI) and hyperspectral imaging (HSI). MALDI imaging aims to provide a label- free, spatially resolved measurement of the abundance of biomolecules by using the difference in their mass-to-charge ratio. This leads to a mass spectrum for each location of a given sample. HSI on the other hand measures the interaction of a sample with a broad light spectrum ranging from the visible to the infrared. This thesis is based on three studies. In the first two studies, I was able to show that complex medical problems in head and neck cancer diagnosis and treatment can be addressed by combining novel imaging techniques with deep learning based data analysis. In the third one, I helped to show, that there is no tumor specific uptake of ICG by combining and analyzing fluorescence microscopy and classical histopathological data.
Author: Hiroya Ojiri
Publisher: Springer Nature
ISBN: 9811531889
Category : Medical
Languages : en
Pages : 221
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Book Description
This succinct compendium focuses on the key practical aspects of head and neck cancer imaging. It also provides essential information on handling and analyzing imaging data. Head and neck cancer is the sixth most common cancer worldwide. CT and MRI imaging are absolutely crucial to accurate diagnosis and staging, and radiologists have to be especially familiar with the anatomy of that region of the body. In addition, they must be highly proficient in interpreting radiographic images in order to judge the patterns of metastasis, response to treatment, and the signs and patterns of recurrence. This concise but detailed book describes the latest imaging modalities for all types of head and neck cancer diagnosis in light of recent technological advances. Featuring abundant high-quality images supplemented by advice from experts on the management of each cancer, it is a valuable resource for diagnostic and general radiologists, as well as all medical staff involved in the management of head and neck cancers.
Author: Robert Hermans
Publisher: Springer Nature
ISBN: 3030647358
Category : Medical
Languages : en
Pages : 518
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Book Description
This book is a comprehensive guide to imaging as a crucial part of the multidisciplinary approach to head and neck cancer management. Readers will find a detailed overview of the findings obtained using different imaging techniques during the evaluation of head and neck neoplasms, both before and after therapy. All anatomic areas in the head and neck are covered, and the impact of imaging on patient management is discussed in detail. Full account is taken of the rapid technological developments of recent years, with explanation of the potential applications, limitations, and advantages of existing and evolving imaging technologies – vital knowledge for all members of the multidisciplinary team. The authors are recognized experts in the field, and numerous high-quality images are included. This third edition includes information on the latest imaging developments in this area as well as the most recent staging classification of head and neck cancer.
Author: Robert Hermans
Publisher: Springer Science & Business Media
ISBN: 3642178685
Category : Medical
Languages : en
Pages : 415
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Book Description
Imaging is crucial in the multidisciplinary approach to head and neck cancer management. The rapid technological development of recent years makes it necessary for all members of the multidisciplinary team to understand the potential applications, limitations, and advantages of existing and evolving imaging technologies. It is equally important that the radiologist has sufficient clinical background knowledge to understand the clinical significance of imaging findings. This book provides an overview of the findings obtained using different imaging techniques during the evaluation of head and neck neoplasms, both before and after therapy. All anatomic areas in the head and neck are covered, and the impact of imaging on patient management is discussed in detail. The authors are recognized experts in the field, and numerous high-quality images are included. This second edition provides information on the latest imaging developments in this area, including the application of PET-CT and diffusion-weighted magnetic resonance imaging.
Author: Vincent Andrearczyk
Publisher: Springer Nature
ISBN: 3030671941
Category : Computers
Languages : en
Pages : 119
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Book Description
This book constitutes the First 3D Head and Neck Tumor Segmentation in PET/CT Challenge, HECKTOR 2020, which was held in conjunction with the 23rd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2020, in Lima, Peru, in October 2020. The challenge took place virtually due to the COVID-19 pandemic. The 2 full and 8 short papers presented together with an overview paper in this volume were carefully reviewed and selected form numerous submissions. This challenge aims to evaluate and compare the current state-of-the-art methods for automatic head and neck tumor segmentation. In the context of this challenge, a dataset of 204 delineated PET/CT images was made available for training as well as 53 PET/CT images for testing. Various deep learning methods were developed by the participants with excellent results.
Author: Girish Fatterpekar
Publisher: Elsevier Health Sciences
ISBN: 0323569897
Category : Medical
Languages : en
Pages :
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Book Description
This issue of MRI Clinics of North America focuses on State-of-the-Art Imaging of Head and Neck Tumors, and is edited by Dr. Girish M. Fatterpekar. Articles will include: Spectral CT: Technique and Applications for Head and Neck Cancer; State-of-the-Art Perfusion Imaging for Head and Neck Cancer; PET-CT in Head and Neck Cancer: Where Do We Currently Stand; Neck Imaging Reporting and Data System (NI-RADS) for Head and Neck Cancer; CT vs MR in Head and Neck Cancer: When to Use What and Image Optimization Strategies; Practical Tips for MR Imaging of Perineural Tumor Spread; High-resolution Extracranial Nerve MR Imaging; Diffusion-weighted Imaging in Head and Neck Cancer: Technique, Limitations, and Applications; Dynamic Contrast-enhanced MR Imaging in Head and Neck Cancer; Update in Parathyroid Imaging; PET-MR Imaging in Head and Neck Cancer: Current Applications and Future Directions, and more!
Author: Jacques Bernier
Publisher: Springer Science & Business Media
ISBN: 1441994645
Category : Medical
Languages : en
Pages : 700
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Book Description
In recent years, great advances in translational research have led to new paradigms in the treatment of cancers of the head and neck. Written by leading international physicians and investigators, this innovative multi-disciplinary book presents the most up-to-date research and clinical approaches. Coverage is given to progress in a variety of clinical settings, including programs of organ and function preservation, curative treatments, unresectable disease, adjuvant treatments in high-risk patients, and recurrent/metastatic disease. Complementary to the techniques of surgery, radiotherapy, and systemic treatments, the authors present data on epidemiology, molecular pathology, normal tissue complications, rehabilitation, palliative care, and treatment in the elderly. State-of-the-art functional imaging is elucidated; and the latest developments in high precision techniques in irradiation, sequencing of chemo- and radiotherapy, as well as the integration of biomolecular therapies into cytotoxic treatments are explored.
Author: Ashok Srinivasan
Publisher: Elsevier Health Sciences
ISBN: 0323755895
Category : Medical
Languages : en
Pages : 240
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Book Description
This issue of Neuroimaging Clinics of North America focuses on State of the Art Evaluation of the Head and Neck and is edited by Dr. Ashok Srinivasan. Articles will include: Diffusion MR in the head and neck: Principles and applications; Perfusion imaging in the head and neck: Go with the flow; MR spectroscopy of the head and neck: Principles, applications and challenges; Technological improvements in head and neck MR: At the cutting edge; Dual Energy CT in head and neck imaging: Pushing the envelope; Role of Ultrasound in head and neck evaluation; PET imaging in the head and neck: Current state and future directions; Patient centric head and neck cancer radiation therapy: Role of advanced imaging; AI in head and neck imaging: Glimpse into the future; NIRADS: Principles and implementation; Common data elements in head and neck reporting; and more!
Author: Peter C. Levendag
Publisher: Elsevier,Urban&FischerVerlag
ISBN: 9783437599040
Category :
Languages : en
Pages : 272
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Book Description
Author: Baixiang Zhao
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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