Collagen- and Fibronectin-mimetic Integrin-specific Surfaces that Promote Osseointegration PDF Download
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Author: Catherine Diane Reyes
Publisher:
ISBN:
Category : Biomedical materials
Languages : en
Pages :
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Book Description
Cell adhesion to the extracellular matrix through cell-surface integrin receptors is essential to development, wound healing, and tissue remodeling and therefore represents a central theme in the design of bioactive surfaces that successfully interface with the body. This is especially significant in the areas of integrative implant coatings since adhesion triggers signals that regulate cell cycle progression and differentiation in multiple cellular systems. The interactions of osteoblasts with their surrounding extracellular matrix are essential for skeletal development and homeostasis and the maintenance of the mature osteoblastic phenotype. Our objective was to engineer integrin-specific bioactive surfaces that support osteoblastic differentiation and promote osseointegration by mimicking these interactions. We target two specific integrins essential to osteoblast differentiation the type I collagen receptor alpha2beta1 and the fibronectin receptor alpha5beta1. The central hypothesis of this project was that the controlled presentation of type I collagen and fibronectin binding domains onto well-defined substrates would result in integrin-specific bioadhesive surfaces that support osteoblastic differentiation, matrix mineralization, and osseointegration. We have demonstrated that these biomimetic peptides enhance bone formation and mechanical osseointegration on titanium implants in a rat tibia cortical bone model. We have also shown that the presentation of multiple integrin-binding ligands synergize to enhance intracellular signaling and proliferation. Finally, we demonstrate the advantage of the short biomimetic peptides over the native ECM proteins. This research is significant because it addresses current orthopaedic implant limitations by specifically targeting cellular responses that are critical to osteoblastic differentiation and bone formation. This biomolecular approach provides a versatile and robust strategy for developing bioactive surfaces that enhance bone repair and osseointegration of orthopaedic implants.
Author: Catherine Diane Reyes
Publisher:
ISBN:
Category : Biomedical materials
Languages : en
Pages :
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Book Description
Cell adhesion to the extracellular matrix through cell-surface integrin receptors is essential to development, wound healing, and tissue remodeling and therefore represents a central theme in the design of bioactive surfaces that successfully interface with the body. This is especially significant in the areas of integrative implant coatings since adhesion triggers signals that regulate cell cycle progression and differentiation in multiple cellular systems. The interactions of osteoblasts with their surrounding extracellular matrix are essential for skeletal development and homeostasis and the maintenance of the mature osteoblastic phenotype. Our objective was to engineer integrin-specific bioactive surfaces that support osteoblastic differentiation and promote osseointegration by mimicking these interactions. We target two specific integrins essential to osteoblast differentiation the type I collagen receptor alpha2beta1 and the fibronectin receptor alpha5beta1. The central hypothesis of this project was that the controlled presentation of type I collagen and fibronectin binding domains onto well-defined substrates would result in integrin-specific bioadhesive surfaces that support osteoblastic differentiation, matrix mineralization, and osseointegration. We have demonstrated that these biomimetic peptides enhance bone formation and mechanical osseointegration on titanium implants in a rat tibia cortical bone model. We have also shown that the presentation of multiple integrin-binding ligands synergize to enhance intracellular signaling and proliferation. Finally, we demonstrate the advantage of the short biomimetic peptides over the native ECM proteins. This research is significant because it addresses current orthopaedic implant limitations by specifically targeting cellular responses that are critical to osteoblastic differentiation and bone formation. This biomolecular approach provides a versatile and robust strategy for developing bioactive surfaces that enhance bone repair and osseointegration of orthopaedic implants.
Author: Lucy Di Silvio
Publisher: Elsevier
ISBN: 184569547X
Category : Technology & Engineering
Languages : en
Pages : 649
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Book Description
The response of cells to biomaterials is critical in medical devices. Traditionally inert biomaterials were used to minimise the reaction in cells in contact with the material. However, it has been realised that specific cell responses may be beneficial in such areas as encouraging adhesion, healing or cell multiplication. Cellular response to biomaterials discusses the response of cells to a wide range of biomaterials targeted at specific medical applications. Part one discusses cell responses to a variety of polymers and ceramics with chapters on such topics as degradable polymers and biocompatibility. Part two covers cell responses and regenerative medicine with coverage of themes such as vascular grafts, nerve repair and Bioglass®. Part three examines the effect of surfaces and proteins on cell response. Specific chapters review nano-engineered surfaces, the influence of plasma proteins on bone cell adhesion and surface modification of titanium implants. With its distinguished editor and team of international contributors, Cellular response to biomaterials is an essential read for those researching or studying medical devices in industry and academia. Examines the response of cells to a wide range of biomaterials targeted at specific medical applications Discusses cell responses and regenerative medicine with specific chapters on vascular grafts and nerve repair Assesses the effect of surfaces and proteins on cell response including the influence of plasma proteins on cell adhesion and surface modification of titanium implants
Author: Andres Garcia
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Kevin Healy
Publisher: Elsevier
ISBN: 0081006926
Category : Technology & Engineering
Languages : en
Pages : 4865
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Book Description
Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications
Author: William R Wagner
Publisher: Academic Press
ISBN: 0128161388
Category : Technology & Engineering
Languages : en
Pages : 1612
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Book Description
The revised edition of the renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science from principles to applications. Biomaterials Science, fourth edition, provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine.This new edition incorporates key updates to reflect the latest relevant research in the field, particularly in the applications section, which includes the latest in topics such as nanotechnology, robotic implantation, and biomaterials utilized in cancer research detection and therapy. Other additions include regenerative engineering, 3D printing, personalized medicine and organs on a chip. Translation from the lab to commercial products is emphasized with new content dedicated to medical device development, global issues related to translation, and issues of quality assurance and reimbursement. In response to customer feedback, the new edition also features consolidation of redundant material to ensure clarity and focus. Biomaterials Science, 4th edition is an important update to the best-selling text, vital to the biomaterials’ community. The most comprehensive coverage of principles and applications of all classes of biomaterials Edited and contributed by the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and updated to address issues of translation, nanotechnology, additive manufacturing, organs on chip, precision medicine and much more. Online chapter exercises available for most chapters
Author: Daniel Christopher Roy
Publisher:
ISBN:
Category :
Languages : en
Pages : 209
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Book Description
"Cutaneous wound repair is a stepwise process governed by interactions between cells and their surrounding extracellular matrix (ECM). Fibronectin is an ECM protein that is typically up-regulated following cutaneous injury. Conversely, decreased fibronectin levels are associated with non-healing, chronic wounds. Fibronectin exists in the body in both a soluble form and in an insoluble, ECM form. The ECM form of fibronectin specifically stimulates cell and tissue processes critical to wound repair including cell growth, cell migration, and ECM deposition and organization. The bioactivity of ECM fibronectin has been localized, in part, to the matricryptic heparin-binding domain located within FNIII1 (FNIII1H). We have engineered a series of fibronectin matrix mimetics by directly coupling the matricryptic FNIII1H domain to variants of the integrin-binding domain of fibronectin (FNIII8-10). The purpose of the studies described in this dissertation was to optimize the design of fibronectin matrix mimetics to accelerate the healing of chronic, cutaneous wounds. Previous studies from our laboratory have shown that the construct GST/III1H,8-10 enhances cell growth, migration, and contractility when added in solution to collagen-adherent cells. Here, I show that deletion mutations can be made to the integrin-binding domain of GST/III1H,8-10 without compromising bioactivity. As adhesive substrates, the constructs GST/III1H,8-10, GST/III1H,8,10 and GST/III1H,8RGD each promoted cell growth and cell migration to a similar or greater extent than full-length fibronectin. GST/III1H,8-10, GST/III1H,8,10 and GST/III1H,8RGD stimulated collagen gel contraction to a greater extent than GST controls. Fibronectin matrix mimetics also served as integrin-specific adhesive substrates to direct fibronectin matrix assembly. In turn, topical application of fibronectin matrix mimetics to punch biopsy wounds of diabetic mice improved healing by increasing the deposition of collagen-rich granulation tissue. Further, the construct GST/III1H,8-10 accelerated wound closure over GST-treated wounds. The studies presented herein suggest that fibronectin matrix mimetics make promising candidates to serve as bioactive coatings for tissue engineered scaffolds and as therapeutic agents to improve healing of chronic wounds"--Page vi-vii.
Author: David A. Puleo
Publisher: Springer Science & Business Media
ISBN: 0387981616
Category : Technology & Engineering
Languages : en
Pages : 438
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Book Description
Success or failure of biomaterials, whether tissue engineered constructs, joint and dental implants, vascular grafts, or heart valves, depends on molecular-level events that determine subsequent responses of cells and tissues. This book presents the latest developments and state-of-the-art knowledge regarding protein, cell, and tissue interactions with both conventional and nanophase materials. Insight into these biomaterial surface interactions will play a critical role in further developments in fields such as tissue engineering, regenerative medicine, and biocompatibility of implanted materials and devices. With chapters written by leaders in their respective fields, this compendium will be the authoritative source of information for scientists, engineers, and medical researchers seeking not only to understand but also to control tissue-biomaterial interactions.
Author: Soroush Nazarpour
Publisher: Springer Science & Business Media
ISBN: 9400725922
Category : Science
Languages : en
Pages : 367
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Book Description
The surface of materials is routinely exposed to various environmental influences. Surface modification presents a technological challenge for material scientists, physicists, and engineers, particularly when those surfaces are subjected to function within human body environment. This book provides a comprehensive coverage of the major issues and topics dealing with interaction of soft living matter with the surface of implants. Fundamental scientific concepts are embedded through experimental data and a broad range of case studies. First chapters cover the basics on biocompatibility of many different thin films of metals, alloys, ceramics, hydrogels, and polymers, following with case studies dealing with orthopedic and dental coatings. Next, a novel and low-cost coating deposition technique capable of production of several types of nanostructures is introduced through simple calculations and several illustrations. Moreover, chapter 6 and 7 present important topics on surface treatment of polymers, which is a subject that has seen many developments over the past decade. The last chapters target mainly the applications of coatings in biology such as in bio-sensing, neuroscience, and cancer detection. With several illustrations, micrographs, and case studies along with suitable references in each chapter, this book will be essential for graduate students and researchers in the multidisciplinary field of bio-coatings.
Author: Thomas J. Webster
Publisher: World Scientific
ISBN: 9812706151
Category : Technology & Engineering
Languages : en
Pages : 260
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Book Description
Nanotechnology is an emerging and exciting area in the field of implants. Numerous promising developments have been elucidated regarding the use of nanotechnology to regenerate tissues. This important book highlights the potential of nanophase materials to improve hard and soft tissue applications. In all cases, increased tissue regeneration has been observed for bone, cartilage, vascular, bladder, and central/peripheral nervous system tissues.
Author: Gregory H. Hudalla
Publisher: Royal Society of Chemistry
ISBN: 1849738335
Category : Medical
Languages : en
Pages : 422
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Book Description
Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.
