Cloning, Expression and Biological Activity of Fibroblast Growth Factors in Early Xenopus Development PDF Download
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Author: Jihwan Song
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Jihwan Song
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author: Jihwan Song
Publisher:
ISBN:
Category : Fibroblast growth factors
Languages : en
Pages : 296
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Author: Wendy Winsor
Publisher:
ISBN:
Category :
Languages : en
Pages :
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In a search for fibroblast growth factor (FGF)-regulated early response genes, four cDNA fragments were isolated via a polymerase chain reaction-based differential display procedure. The cDNA fragments represent portions of genes that were either activated or repressed in Stage 8 Xenopus laevis explants after a 30 minute treatment with lOOng/ml XFGF-2. One 498bp cDNA fragment, named Band V, represents a gene that is downregulated by FGF treatment. This gene is expressed at Stages 8, 9 and 15 in the developing Xenopus embryo. A Genbank homology search program revealed similarity of Band V to distinct regions in an alternatively spliced myocyte enhancer factor, the v-j- c region of a T-cell receptor gamma chain, a Meprin A beta-subunit precursor and a myosin I heavy chain-like protein. The three other cDNA bands isolated from the differential display were chosen due to apparent upregulation by FGF. The 449bp Band VIA/B cDNA fragment possesses regions of similarity to the reactive centre of murine serine proteinase inhibitor 2.4 and a contrapsin-related MC-7 precursor. Upregulation of Band VIA/B was not confirmed because gene expression could not be detected via PCR in Xenopus explants or throughout development. The third Band 11/12, is a 636bp cDNA fragment whose gene is only expressed at Stage 8 of the developing embryo and was upregulated by FGF-2, in a PCR reaction. A database homology search showed that Band 11/12 was similar to a hypothetical protein. A second, 190bp DNA fragment isolated from Band 12 was a portion of the c-mos protooncogene. The fourth and final cDNA Band 22 is 517bp in size and represents a previously cloned Xenopus 146kDa nuclear splicing factor (Schmidt-Zachmann et aL, 1998). This factor is expressed throughout Xenopus development, and control of Band 22 gene expression by FGF-2 could not be confirmed.
Author: Andrew Baird
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 542
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Author:
Publisher: Academic Press
ISBN: 0080857248
Category : Science
Languages : en
Pages : 321
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Book Description
International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Autoregulation of Angiogenesis by Cells of the Vessel Wall Fibroblast Growth Factors as Malfunctional Signaling Factors Structural and Functional Characteristics of the Centrosome in Gametogenesis and Early Embryogenesis of Animals Cell and Molecular Biology of the Pars Tuberalis of the Pituitary Polariation of the Na+, K+-ATPase in Epithelia Derived from Neuroepithelium Desmosomes: Intercellular Adhesive Junctions Specialized for Attachment of Intermediate Filaments
Author: Paul T. Sharpe
Publisher: Springer Science & Business Media
ISBN: 1592592708
Category : Science
Languages : en
Pages : 752
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Most people have some interest in embryos; this probably results, in part, from their interest in understanding the biological origins of themselves and their offspring and, increasingly, concerns about how environmental change such as pollution might affect human development. Obviously, et- cal considerations preclude experimental studies of human embryos and, c- sequently, the developmental biologist has turned to other species to examine this process. Fortunately, the most significant conclusion to be drawn from the experimental embryology of the last two decades is the manner in which orthologous or closely related molecules are deployed to mediate similar - velopmental processes in both vertebrates and invertebrates. The molecular mechanisms regulating processes fundamental to most animals, such as axial patterning or axon guidance, are frequently conserved during evolution. (It is now widely believed that the differences between phyla and classes are the result of new genes, arising mostly by duplication and divergence of extant sequences, regulating the appearance of derived characters. ) Other vertebrates are obviously most likely to use the same devel- mental mechanisms as humans and, within the vertebrate subphylum, the - parent degree of conservation of developmental mechanism is considerable. It has long been recognized that particular vertebrate species offer either d- tinct advantages in investigating particular stages of development or are - pecially amenable to particular manipulations. No single animal can provide all the answers because not all types of experiments can be carried out on a single species.
Author: Ramon Lim
Publisher: Springer Science & Business Media
ISBN: 0387303480
Category : Medical
Languages : en
Pages : 691
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Book Description
"The Handbook is intended to be a service to the neuroscience community, to help in finding available and useful information, to point out gaps in our knowledge, and to encourage continued studies. It represents the valuable contributions of the many authors of the chapters and the guidance of the editors and most important, it represents support for research in this discipline. Based on the rapid advances in the years since the second edition."--Publisher's website.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309070864
Category : Nature
Languages : en
Pages : 348
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Book Description
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Author: Thomas R. Ziegler
Publisher: Springer Science & Business Media
ISBN: 1461218764
Category : Medical
Languages : en
Pages : 374
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Book Description
The aim of this symposium was to provide basic and clinical investigators with the latest information on the biology of wound healing and tissue repair. Written and edited by eminent experts in the field, the papers cover the general concepts of wound healing; the role of nutrients; endogenous growth factors; clinical applications of growth hormone and IGF-1 therapy; and clinical applications of peptide growth factors.
Author: Sir John Kendrew
Publisher: John Wiley & Sons
ISBN: 1444313843
Category : Science
Languages : en
Pages : 1201
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Book Description
The Encylopaedia of Molecular Biology is a truly unique work of reference. 6000 definitions cover the entire spectrum of molecular life science The complete one-volume guide to understanding the way molecular biology is transforming medicine and agriculture Long and short entries written by over 300 of the world's finest researchers For rapid research or detailed study ... this is the A to Z of the New Biology
