Cloning and Characterization of Two Genes Encoding Arylalkylamine N-acetyltransferases in Drosophila Melanogaster PDF Download
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Author: Remo Amherd
Publisher:
ISBN:
Category :
Languages : en
Pages : 326
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Author: Remo Amherd
Publisher:
ISBN:
Category :
Languages : en
Pages : 326
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Author: Kenneth David Becker
Publisher:
ISBN:
Category : Drosophila melanogaster
Languages : en
Pages : 390
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Book Description
Drosophila melanogaster is a well characterized genetic system that can be easily manipulated to generate mutants affecting muscle assembly, structure and/or function. Coupling mutants with the ability to reintroduce genes into the Drosophila genome provides a powerful approach in which to study sequence specific function as it relates to muscle structural proteins. In chapter 1 we show that Drosophila melanogaster muscles contain the standard form of the thick filament protein paramyosin, as well as a novel paramyosin isoform, which we call miniparamyosin. Standard paramyosin is [approx]105 kD and cross-reacts with polyclonal antibodies made against Caenorhabditis elegans or Heliocopris dilloni paramyosin. The Heliocopris antibody also cross-reacts with a [approx]55 kD protein likely to be miniparamyosin. We have cloned and sequenced cDNA's encoding both Drosophila isoforms. The C-terminal 363 amino acids are identical in standard and miniparamyosin. However, the smaller isoform has 114 residues at the N terminus that are unique as compared to the current protein sequence data base. In-situ hybridization to Drosophila tissue sections shows that standard paramyosin is expressed in all larval and adult muscle tissues whereas miniparamyosin is restricted to a subset of the adult musculature. In chapter two we characterize the partial structure of the Drosophila paramyosin gene. This gene is single copy per haploid genome and utilizes two promoters to generate mRNA's that have either of two different 5' coding sequences joined to common 3' exons. We also show that a chromosomal deficient eliminates the function of the Drosophila paramyosin gene. This deficiency is homozygous lethal at the first larval instar stage and has a morphological phenotype which suggests that muscle function is impaired. Finally, in chapter 3 we describe the cloning of two different genomic DNA fragments that each contain the heavy chain gene (MHC) of Drosophila melanogaster. Both of these clones have been used to create transgenic lines. The expression level from these MHC transgenes has been determined to be from 0 to 60% of the wild type haploid amount. However, even multiple copies of the transgenes are unable to rescue the dominant flightless and recessive lethal phenotypes associated with Mhc hypomorphic mutants.
Author: Richard John George Southgate
Publisher:
ISBN:
Category :
Languages : fr
Pages : 154
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Book Description
![Cloning and Characterization of the Drosophila Melanogaster Dgq Gene Encoding an Eye Specific G[alpha] Molecule PDF](https://books.google.com/books/content/images/frontcover/W2_9tgAACAAJ?fife=w80-h100)
Author: Young Jae Lee
Publisher:
ISBN:
Category :
Languages : en
Pages : 280
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Author:
Publisher:
ISBN:
Category : Cytology
Languages : en
Pages : 464
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Author:
Publisher: Academic Press
ISBN: 0128036087
Category : Medical
Languages : en
Pages : 2494
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Book Description
Hormones, Brain and Behavior, Third Edition offers a state-of-the-art overview of hormonally-mediated behaviors, including an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. Entries have been carefully designed to provide a valuable source of information for students and researchers in neuroendocrinology and those working in related areas, such as biology, psychology, psychiatry, and neurology. This third edition has been substantially restructured to include both foundational information and recent developments in the field. Continuing the emphasis on interdisciplinary research and practical applications, the book includes articles aligned in five main subject sections, with new chapters included on genetic and genomic techniques and clinical investigations. This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topics cover an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields. Comprehensive and updated coverage of a rapidly growing field of research Unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics Covers an unusual breadth of topics and subject fields, ranging from molecules to ecophysiology, and from basic science to clinical research Ideal resource for interdisciplinary learning and understanding in the fields of hormones and behavior
Author: Ephraim Cohen
Publisher: Springer
ISBN: 3319407406
Category : Science
Languages : en
Pages : 715
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Book Description
Emphasis is placed on the elaborate cuticular matrices in insects and crustaceans, spider and insect silks, sialomes of phytophagous and blood-feeding arthropods as well as on secretions of male and female accessory glands. Focus is placed largely on insects, due to the extensive body of published research that in part is the result of available whole genome sequences of several model species (in particular Drosophila melanogaster) and accessible ESTs for other species. Such advances have facilitated fundamental insights into genomic, proteomic and molecular biology-based physiology. This new volume contains comprehensive contributions on extracellular composite matrices in arthropods. The building blocks of such matrices are formed in and secreted by single layered epithelial cells into exterior domains where their final assembly takes place.Additionally, the unique mechanical properties of natural biocomposites like chitin/chitosan, the crustacean mineralized exoskeleton, the pliant protein resilin or insect and spider silks, have inspired basic and applied research that yield sophistical biomimetics and structural biocomposite hybrids important for future industrial and biomedical use. In summary, this book provides an invaluable vast source of basic and applied information for a plethora of scientists as well as textbook for graduate and advanced undergraduate students.
Author:
Publisher:
ISBN:
Category : Genetics
Languages : en
Pages : 758
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Author: Ralph Lydic
Publisher: CRC Press
ISBN: 9781420048247
Category : Science
Languages : en
Pages : 722
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Book Description
Handbook of Behavioral State Control: Cellular and Molecular Mechanisms provides the first synthesis of information on the neurobiology of behavioral states, ranging from normal stress and sleep deprivation to debilitating neuropsychiatric disorders. This book presents a working reference on the cellular and molecular mechanisms generating arousal states; pharmacological and non-pharmacological methods of behavioral state control; and the bi-directional interaction between arousal state and the neurobiology of pain, and between sleep and the immune system.
Author:
Publisher:
ISBN:
Category : Entomology
Languages : en
Pages : 982
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Book Description
Monthly, with annual author and subject indexes. Abstracts from about 2750 primary journals dealing with the subject of insects. Arranged in classified order. Entries include titles given or translated into English, authors, addresses offirst authors, and abstracts; all insects cited in the abstracts are identified by scientific family names. Each monthly issue has Index to classes and orders, Author index.
