Characterization of Hypoxia-inducible Factor-1[alpha] (HIF-1[alpha]) and Its Involvement in Oxygen-dependent Transferrin Expression PDF Download
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![Characterization of Hypoxia-inducible Factor-1[alpha] (HIF-1[alpha]) and Its Involvement in Oxygen-dependent Transferrin Expression PDF](https://books.google.com/books/content/images/frontcover/RJtpuAAACAAJ?fife=w150-h200)
Author: Andreas Rolfs
Publisher:
ISBN:
Category :
Languages : en
Pages : 28
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Book Description
![Characterization of Hypoxia-inducible Factor-1[alpha] (HIF-1[alpha]) and Its Involvement in Oxygen-dependent Transferrin Expression PDF](https://books.google.com/books/content/images/frontcover/RJtpuAAACAAJ?fife=w80-h100)
Author: Andreas Rolfs
Publisher:
ISBN:
Category :
Languages : en
Pages : 28
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Book Description
Author: Andreas Rolfs
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author: Andreas Rolfs
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 28
Get Book Here
Book Description
![Characterization of Hypoxia-inducible Factor-1[alpha] (HIF-1[alpha]) and Its Involvemnet in Oxygen-dependent Transferrin Expression PDF](https://books.google.com/books/content/images/frontcover/W9xwNwAACAAJ?fife=w80-h100)
Author: Andreas Rolfs
Publisher:
ISBN:
Category :
Languages : en
Pages : 165
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Book Description
Author: Andreas Rolfs
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Amira F. Mohamed
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Preconditioning to lowered oxygen levels (hypoxia) may occur when an animal is subjected to non-lethal levels of hypoxia and then returned to normoxic conditions. During a subsequent exposure to hypoxia, the pre-exposed animals may exhibit increased tolerance compared to naive animals. I have demonstrated, by analysis of critical PO2's (Pcrit), that zebrafish embryos can be preconditioned to hypoxia. Preconditioned embryos display a lower Pcrit than controls, indicating a heightened ability to endure hypoxic conditions. The role of the hypoxia inducible factor-1 (HIF-1) in promoting hypoxic preconditioning was examined. To determine the role of HIF-1 in preconditioning, embryos deficient in HIF-1alpha (using antisense oligonucleotide morpholinos) were assessed under hypoxic conditions. No significant difference between preconditioning capacities of control- and HIF-1alpha deficient embryos was observed. In addition to assessing Pcrit, a suite of hypoxia responsive genes were analysed by real time PCR. IGFBP-2 showed a significant decrease in expression in the HIF-1alpha deficient embryos, and EPO showed a significant increase in HIF-1alpha deficient embryos. All other genes examined showed no significant change between treated and control embryos.
Author: Bharat B. Aggarwal
Publisher: Springer
ISBN: 3034808372
Category : Medical
Languages : en
Pages : 489
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Book Description
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Author: Robert C. Roach
Publisher: Springer Science & Business Media
ISBN: 1441989978
Category : Medical
Languages : en
Pages : 367
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Book Description
The International Hypoxia Symposium convenes biannually to bring together international experts from many fields to explore the state of the art in normal and pathophysiological responses to hypoxia. Representatives from five continents and 32 countries joined together in February 2003 for four days in the dramatic mountains of Banff, Alberta. As editors of the Proceedings of the International Hypoxia Symposia, we strive to maintain a 26 six year tradition of presenting a stimulating blend of clinical and basic science papers focused on hypoxia. Topics covered in 2003 include hibernation and hypoxia, hypoxia and fetal development and new advances in high altitude pathophysiology, oxidative stress and membrane damage, hypoxic regulation of blood flow, heat shock proteins in hypoxia, and future directions in hypoxia research. In 2003 we also had the privilege ofhonoring John W. Severinghaus as a friend, colleague, mentor and inspiration to many in the field. Tom Hornbein's personal tribute to John Severinghaus is the first chapter in this volume, followed by an entertaining update of the history of the discovery of oxygen written by John Severinghaus.
Author: Nader G. Abraham
Publisher: Springer Science & Business Media
ISBN: 1461547970
Category : Medical
Languages : en
Pages : 393
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Book Description
This volume of Molecular Biology of Hematopoiesis is dedicated to many inter national scientists and clinicians for their contribution to the field of Hematology/ Oncology presented at the 11th International Symposium on Molecular Biology of Hematopoiesis, which was held in Bormio, Italy, June 25-29, 1998. The continuous support of the Presidents of the meeting, Professor F. Takaku, President of Jichi University, and E. D. Thomas, Nobel Laureate, was greatly acknowledged, especially Professor Takaku, for his vision and support for development of gene therapy in Japan. New information on BMT for autoimmune disease and organ transplantation was presented at the symposium and is published in this volume. Several new findings on gene therapy/transfer into HSC were presented by E. F. Vanin and A. Nienhuis, K. Humphries, 1. A. Nolta, H. E. Heslop, and M. K. Brenner. Professors S. Asano and K. Tani presented new studies on gene transfer into primates. Among the highlights were the new papers on gene transfer presented by G. Wage maker, N. G. Abraham, and M. Onoderea from R. M. BJaese's group. The use of BMT for organ transplant and autoim mune disease was updated and a representative paper is presented in this volume.
